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Open AccessArticle

TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery

1
Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Spain
2
Departamento de Anestesiología y Reanimación, Hospital Clínico Universitario, 47005 Valladolid, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this study.
J. Clin. Med. 2019, 8(3), 283; https://doi.org/10.3390/jcm8030283
Received: 28 January 2019 / Revised: 15 February 2019 / Accepted: 18 February 2019 / Published: 26 February 2019
Background: In many immune-related diseases, inflammatory responses and several clinical outcomes are related to increased NF-κB activity. We aimed to evaluate whether SNPs related to the NF-κB signaling pathway are associated with higher susceptibility to infection, septic shock, and septic-shock-related death in European patients who underwent major surgery. Methods: We performed a case-control study on 184 patients with septic shock and 212 with systemic inflammatory response syndrome, and a longitudinal substudy on septic shock patients. Thirty-three SNPs within genes belonging to or regulating the NF-κB signaling pathway were genotyped by Agena Bioscience’s MassARRAY platform. Results: No significant results were found for susceptibility to infection and septic shock in the multivariate analysis after adjusting for multiple comparisons. Regarding septic-shock-related death, patients with TNFAIP3 rs6920220 AA, TNIP1 rs73272842 AA, TNIP1 rs3792783 GG, and TNIP1 rs7708392 CC genotypes had the highest risk of septic-shock-related death in the first 28 and 90 days. Also, the MyD88 rs7744 GG genotype was associated with a higher risk of death during the first 90 days. Haplotype analysis shows us that patients with the TNIP1 GAG haplotype (composed of rs73272842, rs3792783, and rs7708392) had a lower risk of death in the first 28 days and the TNIP1 AGC haplotype was associated with a higher risk of death in the first 90 days. Conclusions: The SNPs in the genes TNFAIP3, TNIP1, and MyD88 were linked to the risk of septic-shock-related death in patients who underwent major surgery. View Full-Text
Keywords: TNFAIP3; TNIP1; MyD88; SNPs; septic shock; survival; major surgery TNFAIP3; TNIP1; MyD88; SNPs; septic shock; survival; major surgery
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Jiménez-Sousa, M.Á.; Fadrique, A.; Liu, P.; Fernández-Rodríguez, A.; Lorenzo-López, M.; Gómez-Sánchez, E.; Gómez-Sanz, A.; Heredia-Rodríguez, M.; Gómez-Pesquera, E.; Martínez, I.; Tamayo, E.; Resino, S. TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery. J. Clin. Med. 2019, 8, 283.

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