Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department
Abstract
1. Introduction
2. Materials and Methods
2.1. Patients Enrollment and Inclusion Criteria
2.2. MiRNA Isolation and Quantitative Reverse Transcription PCR (qRT-PCR) Analysis
2.3. Serum HIF-1α and VEGF-A ELISA Assays
2.4. Statistical Analysis
3. Results
3.1. MiRNAs Timing in AIS and TIA Patients
3.2. HIF-1α in AIS and TIA Patients
3.3. VEGF in AIS and TIA Patients
4. Discussion
5. Limitations
Author Contributions
Conflicts of Interest
References
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Control | AIS | TIA | p Value | |
---|---|---|---|---|
N (M) | 20 (11) | 18 (6) | 18 (7) | |
Age (years) | 72.7 ± 3 | 73.3 ± 2 | 74.2 ± 3 | n.s. |
BMI (kg/m2) | 26.4 ± 3 | 27.2 ± 2 | 25 ± 3 | n.s. |
SBP (mmHg) | 138 ± 6 | 145 ± 6 | 142 ± 7 | n.s. |
DBP (mmHg) | 81 ± 3 | 83 ± 2 | 85 ± 2 | n.s. |
Hypertension (%) | 6 (50) | 10 (55) | 9 (50) | n.s. |
Diabetes (%) | 4 (33) | 8 (44) | 6 (33) | n.s. |
Smoking (%) | 3 (25) | 5 (27) | 7 (38) | n.s. |
Hyperlipidemia (%) | 4 (33) | 8 (44) | 7 (38) | n.s. |
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Giordano, M.; Ciarambino, T.; D’Amico, M.; Trotta, M.C.; Di Sette, A.M.; Marfella, R.; Malatino, L.; Paolisso, G.; Adinolfi, L.E. Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department. J. Clin. Med. 2019, 8, 130. https://doi.org/10.3390/jcm8020130
Giordano M, Ciarambino T, D’Amico M, Trotta MC, Di Sette AM, Marfella R, Malatino L, Paolisso G, Adinolfi LE. Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department. Journal of Clinical Medicine. 2019; 8(2):130. https://doi.org/10.3390/jcm8020130
Chicago/Turabian StyleGiordano, Mauro, Tiziana Ciarambino, Michele D’Amico, Maria Consiglia Trotta, Alessandra Marinella Di Sette, Raffaele Marfella, Lorenzo Malatino, Giuseppe Paolisso, and Luigi Elio Adinolfi. 2019. "Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department" Journal of Clinical Medicine 8, no. 2: 130. https://doi.org/10.3390/jcm8020130
APA StyleGiordano, M., Ciarambino, T., D’Amico, M., Trotta, M. C., Di Sette, A. M., Marfella, R., Malatino, L., Paolisso, G., & Adinolfi, L. E. (2019). Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department. Journal of Clinical Medicine, 8(2), 130. https://doi.org/10.3390/jcm8020130