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Open AccessArticle

Platelet-Rich Plasma as Adjuvant Therapy for Recurrent Vesicovaginal Fistula: A Prospective Case Series

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nd Department of Gynecology, Medical University in Lublin, Jaczewskiego 8, 20-954 Lublin, Poland
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Department of Gynecology, Gynecologic Oncology and Gynecologic Endocrinology, Medical University of Gdańsk, Ul. Smoluchowskiego 17, 80-214 Gdańsk, Poland
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Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(12), 2122; https://doi.org/10.3390/jcm8122122
Received: 1 November 2019 / Revised: 26 November 2019 / Accepted: 27 November 2019 / Published: 2 December 2019
:Vesicovaginal fistula (VVF) is the nonphysiological communication between the bladder and vagina, and surgical closure is the gold treatment standard. Despite that successful closure occurs in around 85% of patients after the first repair, recurrence remains a highly distressing complication for patients and surgeons. The aim of our study was to evaluate the efficacy of a platelet-rich plasma (PRP) injection as a supportive treatment in the surgical repair of recurrent VVF. Between January 2018 and July 2019, 16 patients with recurrent VVF were injected with PRP in a tertiary gynecological department. Subsequently, a surgical Latzko procedure for VVF closure was scheduled 6–8 weeks after the PRP injection allowing proper neovascularization and remodeling of surrounding tissues. Patients were considered cured if no leakage was observed after surgery and negative dye test results were indicated at follow-up. All patients who were examined therein remained dry. To the best of our knowledge, this is the first study aiming to assess PRP injections as a supporting treatment prior to surgical procedure for recurrent VVF. Preliminary results are encouraging, and we incorporated this method in our clinical practice. Further reports on a larger group will follow.
Keywords: platelet-rich plasma; vesicovaginal fistula; urogenital fistula; urinary diversion; fibrin glue; Latzko procedure platelet-rich plasma; vesicovaginal fistula; urogenital fistula; urinary diversion; fibrin glue; Latzko procedure
MDPI and ACS Style

Streit—Ciećkiewicz, D.; Futyma, K.; Miotła, P.; Grzybowska, M.E.; Rechberger, T. Platelet-Rich Plasma as Adjuvant Therapy for Recurrent Vesicovaginal Fistula: A Prospective Case Series. J. Clin. Med. 2019, 8, 2122.

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