Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications
by
Armita Mahdavi Gorabi 1,†, Nasim Kiaie 1,†, Saeideh Hajighasemi 2, Maciej Banach 3,4, Peter E. Penson 5
, Tannaz Jamialahmadi 6,7 and Amirhossein Sahebkar 8,9,10,*
Armita Mahdavi Gorabi 1,†, Nasim Kiaie 1,†, Saeideh Hajighasemi 2, Maciej Banach 3,4, Peter E. Penson 5, Tannaz Jamialahmadi 6,7 and Amirhossein Sahebkar 8,9,10,*
1
Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran
2
Department of Medical Biotechnology, Faculty of Paramedicine, Qazvin University of Medical Sciences, Qazvin 1531534199, Iran
3
Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, 93-338 Lodz, Poland
4
Polish Mother’s Memorial Hospital Research Institute (PMMHRI), 93-338 Lodz, Poland
5
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
6
Halal Research Center of IRI, FDA, Tehran 1411713138, Iran
7
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
8
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
9
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
10
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
*
Author to whom correspondence should be addressed.
†
The authors contributed equally as the first author.
J. Clin. Med. 2019, 8(12), 2051; https://doi.org/10.3390/jcm8122051
Received: 21 October 2019 / Revised: 16 November 2019 / Accepted: 20 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue Current and Emerging Uses of Statins in Clinical Therapeutics)
In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed.
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Keywords:
statin; endothelial nitric oxide; angiogenesis; heart failure; atherosclerosis; cancer; neuroprotection
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MDPI and ACS Style
Gorabi, A.M.; Kiaie, N.; Hajighasemi, S.; Banach, M.; Penson, P.E.; Jamialahmadi, T.; Sahebkar, A. Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications. J. Clin. Med. 2019, 8, 2051.
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