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The Role of Protein SUMOylation in the Pathogenesis of Atherosclerosis

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Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran
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Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
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School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
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Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, 93-338 Lodz, Poland
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Polish Mother’s Memorial Hospital Research Institute (PMMHRI), 93-338 Lodz, Poland
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Halal Research Center of IRI, FDA, Tehran, Iran
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Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
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Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
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Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9188617871, Iran
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 1856; https://doi.org/10.3390/jcm8111856
Received: 23 September 2019 / Revised: 27 October 2019 / Accepted: 28 October 2019 / Published: 2 November 2019
(This article belongs to the Section Vascular Medicine)
Atherosclerosis is a progressive, inflammatory cardiovascular disorder characterized by the development of lipid-filled plaques within arteries. Endothelial cell dysfunction in the walls of blood vessels results in an increase in vascular permeability, alteration of the components of the extracellular matrix, and retention of LDL in the sub-endothelial space, thereby accelerating plaque formation. Epigenetic modification by SUMOylation can influence the surface interactions of target proteins and affect cellular functionality, thereby regulating multiple cellular processes. Small ubiquitin-like modifier (SUMO) can modulate NFκB and other proteins such as p53, KLF, and ERK5, which have critical roles in atherogenesis. Furthermore, SUMO regulates leukocyte recruitment and cytokine release and the expression of adherence molecules. In this review, we discuss the regulation by SUMO and SUMOylation modifications of proteins and pathways involved in atherosclerosis. View Full-Text
Keywords: small ubiquitin-like modifier (SUMO); SUMOylation; atherosclerosis small ubiquitin-like modifier (SUMO); SUMOylation; atherosclerosis
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Dehnavi, S.; Sadeghi, M.; Penson, P.E.; Banach, M.; Jamialahmadi, T.; Sahebkar, A. The Role of Protein SUMOylation in the Pathogenesis of Atherosclerosis. J. Clin. Med. 2019, 8, 1856.

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