Next Article in Journal
Comparing the Effect of Dipeptidyl-Peptidase 4 Inhibitors and Sulfonylureas on Albuminuria in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Prospective Open-Label Study
Next Article in Special Issue
Presence of ROS in Inflammatory Environment of Peri-Implantitis Tissue: In Vitro and In Vivo Human Evidence
Previous Article in Journal
Monochorionic Twins: A Delicate Balance
Previous Article in Special Issue
A Finite Element Analysis to Compare Stress Distribution on Extra-Short Implants with Two Different Internal Connections
Retraction published on 17 June 2020, see J. Clin. Med. 2020, 9(6), 1888.
Article

Nurse’s A-Phase–Silicocarnotite Ceramic–Bone Tissue Interaction in a Rabbit Tibia Defect Model

1
Orthopaedic Surgery and Traumatology Service, Santa Lucia University Hospital, 30202 Cartagena (Murcia), Spain
2
Regeneration and Tissue Repair Group, School of Medicine, Universidad Católica de Murcia, 30107 Murcia, Spain
3
Department of Radiology and Physical Medicine, School of Medicine, University of Murcia, 30100 Murcia, Spain
4
Department of Pathology. Reina Sofia University Hospital, University of Murcia, 30003 Murcia, Spain
5
Periodontology Department, Universidad Católica de Murcia, 30107 Murcia, Spain
6
Department of Oral and Implant Surgery, Universidad Católica de Murcia, 30107 Murcia, Spain
7
Instituto de Bioingeniería Universidad Miguel Hernández, Avda. Ferrocarril s/n. 03202 Elche (Alicante), Spain
*
Author to whom correspondence should be addressed.
Equal contribution.
J. Clin. Med. 2019, 8(10), 1714; https://doi.org/10.3390/jcm8101714
Received: 9 September 2019 / Revised: 11 October 2019 / Accepted: 15 October 2019 / Published: 17 October 2019
(This article belongs to the Special Issue Biomaterials and Implants in Development Osteointegration)
Calcium phosphate materials are widely used as bone substitutes due to their bioactive and biodegradable properties. Also, the presence of silicon in their composition seems to improve the bioactivity of the implant and promote bone tissue repair. The aim of this study was to develop a novel ceramic scaffold by partial solid-state sintering method with a composition lying in the field of the Nurse’s A-phase–silicocarnotite, in the tricalcium phosphate–dicalcium silicate (TCP–C2S) binary system. Also, we evaluated its osteogenic and osteoconductive properties after being implanted into tibia defects in New Zealand rabbits. X-ray, microcomputer tomography, and histomorphometry studies demonstrated that this porous ceramic is highly biocompatible and it has excellent osteointegration. The material was being progressively reabsorbed throughout the study and there was no unspecified local or systemic inflammatory response observed. These results suggest that ceramic imitates the physicochemical characteristics of bone substitutes used in bone reconstruction. View Full-Text
Keywords: bone substitutes; calcium phosphate ceramic; bone regeneration; microcomputer tomography; Histomorphometry bone substitutes; calcium phosphate ceramic; bone regeneration; microcomputer tomography; Histomorphometry
Show Figures

Figure 1

MDPI and ACS Style

Ñíguez Sevilla, B.; Rabadan-Ros, R.; Alcaraz-Baños, M.; Martínez Díaz, F.; Mate Sánchez de Val, J.E.; López-Gónzalez, I.; Calvo-Guirado, J.L.; De Aza, P.N.; Meseguer-Olmo, L. Nurse’s A-Phase–Silicocarnotite Ceramic–Bone Tissue Interaction in a Rabbit Tibia Defect Model. J. Clin. Med. 2019, 8, 1714. https://doi.org/10.3390/jcm8101714

AMA Style

Ñíguez Sevilla B, Rabadan-Ros R, Alcaraz-Baños M, Martínez Díaz F, Mate Sánchez de Val JE, López-Gónzalez I, Calvo-Guirado JL, De Aza PN, Meseguer-Olmo L. Nurse’s A-Phase–Silicocarnotite Ceramic–Bone Tissue Interaction in a Rabbit Tibia Defect Model. Journal of Clinical Medicine. 2019; 8(10):1714. https://doi.org/10.3390/jcm8101714

Chicago/Turabian Style

Ñíguez Sevilla, Belén, Ruben Rabadan-Ros, Miguel Alcaraz-Baños, Francisco Martínez Díaz, José E. Mate Sánchez de Val, Iván López-Gónzalez, Jose L. Calvo-Guirado, Piedad N. De Aza, and Luis Meseguer-Olmo. 2019. "Nurse’s A-Phase–Silicocarnotite Ceramic–Bone Tissue Interaction in a Rabbit Tibia Defect Model" Journal of Clinical Medicine 8, no. 10: 1714. https://doi.org/10.3390/jcm8101714

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop