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TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone loss
Open AccessEditorial

Comment from the Editor to the Special Issue: “Periodontitis: From Dysbiotic Microbial Immune Response to Systemic Inflammation”

Department of Odontology, Umeå University, S-901 87 Umeå, Sweden
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J. Clin. Med. 2019, 8(10), 1706; https://doi.org/10.3390/jcm8101706
Received: 14 October 2019 / Accepted: 15 October 2019 / Published: 16 October 2019
The human oral cavity contains a large number of different microbial habitats. When microbes from the oral indigenous flora colonize the interspace between the tooth and the connective tissue, they induce an inflammatory response. If the microbes are in sufficient numbers, and release components that cause an imbalance in the host inflammatory response, degenerative processes in the surrounding tissues are induced, ultimately resulting in periodontal disease. The disease progress depends on bacterial load, the composition of the microbial community, and host genetic factors. The two most studied periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans express virulence factors, including proteases and exotoxins. Periodontal infections are also linked to the risk pattern of several systemic diseases. We would like to shed light on the mechanisms behind periodontitis and the associations of periodontal infections with systemic inflammation. Seven articles are included in this Special Issue and cover several pathogenic processes in the periodontal infection with capacity to cause imbalance in the host response. Highlights from each of the published papers are summarized and discussed below. View Full-Text
Keywords: periodontitis; cardiovascular diseases; rheumatoid arthritis; Porphyromonas gingivalis; Aggregatibacter actinomycetemcomitans; inflammatory response periodontitis; cardiovascular diseases; rheumatoid arthritis; Porphyromonas gingivalis; Aggregatibacter actinomycetemcomitans; inflammatory response
MDPI and ACS Style

Oscarsson, J.; Johansson, A. Comment from the Editor to the Special Issue: “Periodontitis: From Dysbiotic Microbial Immune Response to Systemic Inflammation”. J. Clin. Med. 2019, 8, 1706.

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