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A Systematic Review and Meta-Analysis of the Impact of Mindfulness Based Interventions on Heart Rate Variability and Inflammatory Markers

by 1,2, 3,4,*, 1,2,5 and 2,6
1
Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
2
Center for Social Sustainability, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden
3
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
4
Stockholm Health Care Services, Region Stockholm, CAP Research Centre, 113 30 Stockholm, Sweden
5
Northern Stockholm Psychiatry, Stockholm Health Care Services, Region Stockholm, 112 81 Stockholm, Sweden
6
Department of Public Health Science, Karolinska Institutet, 171 77 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1638; https://doi.org/10.3390/jcm8101638
Received: 13 September 2019 / Revised: 2 October 2019 / Accepted: 3 October 2019 / Published: 7 October 2019
(This article belongs to the Section Psychiatry)
Mindfulness Based Interventions (MBIs) have recently been increasingly used in clinical settings, and research regarding their effects on health has grown rapidly. However, with regard to the physiological effects of mindfulness practices, studies have reported associations that vary in strength and direction. Therefore, in this systematic review and meta-analysis, we aimed to systematically identify, appraise, and summarize the existing data from randomized and non-randomized controlled trials that examine physiological effects of the standardized MBIs by focusing on pro-inflammatory cytokines and C-reactive protein, and commonly used heart rate variability parameters. The following electronic databases were searched: MEDLINE (via Ovid), PsychINFO (via Ovid), PubMed, Web of Science, EMBASE, CINAHL, ProQuest (Dissertations and Theses), and Centre for Reviews and Dissemination. The systematic review identified 10 studies to be included in the meta-analysis, comprising in total 607 participants. The meta-analysis ended up with mixed and inconclusive results. This was assumedly due to the small number of the original studies and, in particular, to the lack of large, rigorously conducted RCTs. Therefore, the current meta-analysis highlights the necessity of larger, more rigorously conducted RCTs on physiological outcomes with standardized MBIs being compared to various forms of active controls, and with more long-term follow-ups. View Full-Text
Keywords: Mindfulness Based Interventions; Interleukins; C-reactive protein; heart rate variability; meta-analysis Mindfulness Based Interventions; Interleukins; C-reactive protein; heart rate variability; meta-analysis
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MDPI and ACS Style

Rådmark, L.; Sidorchuk, A.; Osika, W.; Niemi, M. A Systematic Review and Meta-Analysis of the Impact of Mindfulness Based Interventions on Heart Rate Variability and Inflammatory Markers. J. Clin. Med. 2019, 8, 1638. https://doi.org/10.3390/jcm8101638

AMA Style

Rådmark L, Sidorchuk A, Osika W, Niemi M. A Systematic Review and Meta-Analysis of the Impact of Mindfulness Based Interventions on Heart Rate Variability and Inflammatory Markers. Journal of Clinical Medicine. 2019; 8(10):1638. https://doi.org/10.3390/jcm8101638

Chicago/Turabian Style

Rådmark, Lina, Anna Sidorchuk, Walter Osika, and Maria Niemi. 2019. "A Systematic Review and Meta-Analysis of the Impact of Mindfulness Based Interventions on Heart Rate Variability and Inflammatory Markers" Journal of Clinical Medicine 8, no. 10: 1638. https://doi.org/10.3390/jcm8101638

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