Long-Term Pancreatic Functional Impairment after Surgery for Neuroendocrine Neoplasms
Abstract
1. Introduction
2. Experimental Section
2.1. Study Design
2.2. Definition of Outcomes
2.3. Data Collection
2.4. Statistical Analysis
3. Results
3.1. Study Population
3.2. Postoperative DM
3.3. Postoperative PEI
3.4. Long-Term Oncological Outcomes
4. Discussion
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Variable | n (%) |
---|---|
Operative time, min 1 | 240 (180;300) |
Length of stay, days 1 | 9 (7;11) |
Readmission | |
No | 242 (88) |
Yes | 34 (12) |
Blood transfusion | |
No | 229 (83) |
Yes | 47 (17) |
Islet autotransplatation | |
No | 267 (97) |
Yes | 9 (3) |
Complications [26] | |
No complications | 94 (34) |
I | 56 (20) |
II | 89 (32) |
III | 36 (13) |
IV | 1 (1) |
POPF [27] | |
No | 147 (53) |
Yes | 129 (47) |
Abdominal Collection | |
No | 223 (81) |
Yes | 53 (19) |
Postoperative Hemorrhage | |
No | 262 (95) |
Yes | 14 (5) |
Variable | Total Population | No Postoperative DM | Postoperative DM | p Value |
---|---|---|---|---|
n = 276 | n = 210 | n = 68 | ||
Age, years | 58 (49;67) | 56 (46;67) | 60 (56;67) | 0.002 |
Gender | ||||
Male | 138 (50) | 95 (46) | 43 (63) | |
Female | 138 (50) | 113 (54) | 25 (37) | 0.017 |
Preoperative BMI, Kg/m2 | 25 (22;27) | 24 (22;27) | 27 (25;30) | <0.0001 |
PanNEN functionality | ||||
Nonfunctioning | 225 (82) | 163 (78) | 62 (91) | |
Functioning | 51 (18) | 45 (22) | 6 (9) | 0.019 |
Inherited Syndrome | ||||
No | 261 (95) | 194 (93) | 67 (99) | |
Yes | 15 (5) | 14 (7) | 1 (1) | 0.127 |
Type of Surgery | ||||
Pancreaticoduodenectomy | 76 (27) | 61 (29) | 15 (22) | |
Distal Pancreatectomy | 192 (70) | 141 (68) | 51 (75) | |
Atypical Resection | 8 (3) | 6 (3) | 2 (3) | 0.476 |
T stage [28] | ||||
T1–T2 | 180 (65) | 136 (65) | 44 (65) | |
T3–T4 | 96 (35) | 72 (35) | 24 (35) | 0.919 |
Tumor grade [3] | ||||
G1 | 153 (55) | 110 (53) | 43 (63) | |
G2 | 110 (40) | 85 (41) | 25 (37) | |
G3 | 13 (5) | 13 (6) | 0 (0) | 0.065 |
Complications [26] | ||||
No-I-II | 239 (87) | 179 (85) | 60 (88) | |
III-IV | 37 (13) | 29 (15) | 8 (12) | 0.647 |
Variable | OR | 95% C.I. | p |
---|---|---|---|
Gender | |||
Male | 1 | - | |
Female | 0.481 | 0.178–1.305 | 0.151 |
Age | |||
≤60 years | 1 | - | |
>60 years | 0.972 | 0.366–2.579 | 0.954 |
Preoperative BMI | |||
≤25 Kg/m2 | 1 | - | |
>25 Kg/m2 | 4.945 | 1.889–12.943 | 0.001 |
Type of PanNEN | |||
Nonfunctioning | 1 | - | |
Functioning | 0.269 | 0.071–1.022 | 0.054 |
Variable | Total Population | No Postoperative PEI | Postoperative PEI | p Value |
---|---|---|---|---|
n = 276 | n = 158 | n = 118 | ||
Age, years | 58 (49;67) | 58 (49;65) | 60 (47;68) | 0.556 |
Gender | ||||
Male | 138 (50) | 76 (48) | 62 (53) | |
Female | 138 (50) | 82 (52) | 56 (47) | 0.543 |
BMI, Kg/m2 | 24.5 (22.5;27) | 25 (23;28) | 24 (22;25) | 0.005 |
Type of PanNEN | ||||
Non-functioning | 225 (82) | 123 (78) | 102 (86) | |
Functioning | 51 (18) | 35 (22) | 16 (14) | 0.085 |
Inherited Syndrome | ||||
No | 261 (95) | 150 (95) | 111 (94) | |
Yes | 15 (5) | 8 (5) | 7 (6) | 0.793 |
Type of Surgery | ||||
Pancreaticoduodenectomy | 76 (27) | 8 (5) | 68 (58) | |
Distal Pancreatectomy | 192 (70) | 144 (91) | 48 (41) | |
Atypical Resection | 8 (3) | 6 (4) | 2 (1) | <0.0001 |
T stage [28] | ||||
T1–T2 | 180 (65) | 116 (73) | 64 (54) | |
T3–T4 | 96 (35) | 42 (27) | 54 (46) | 0.001 |
Tumor grade [3] | ||||
G1 | 153 (55) | 96 (61) | 57 (48) | |
G2 | 110 (40) | 55 (35) | 55 (47) | |
G3 | 13 (5) | 7 (4) | 6 (5) | 0.108 |
Complications [26] | ||||
No-I-II | 239 (87) | 143 (91) | 96 (81) | |
III-IV | 37 (13) | 15 (9) | 22 (19) | 0.027 |
Variable | OR | 95% C.I. | p |
---|---|---|---|
BMI | |||
≤25 Kg/m2 | 1 | - | |
>25 Kg/m2 | 0.746 | 0.280–1.989 | 0.558 |
Type of Surgery | |||
Distal Pancreatectomy | 1 | - | |
Pancreaticoduodenectomy | 31.68 | 10.622–94.487 | <0.0001 |
Atypical resection | 4.8 | 0.626–36.818 | 0.131 |
T stage [28] | |||
T1–T2 | 1 | - | |
T3–T4 | 1.245 | 0.461–3.365 | 0.665 |
Complications [26] | |||
No-I–II | 1 | - | |
III–IV | 1.464 | 0.330–6.486 | 0.616 |
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Share and Cite
Andreasi, V.; Partelli, S.; Capurso, G.; Muffatti, F.; Balzano, G.; Crippa, S.; Falconi, M. Long-Term Pancreatic Functional Impairment after Surgery for Neuroendocrine Neoplasms. J. Clin. Med. 2019, 8, 1611. https://doi.org/10.3390/jcm8101611
Andreasi V, Partelli S, Capurso G, Muffatti F, Balzano G, Crippa S, Falconi M. Long-Term Pancreatic Functional Impairment after Surgery for Neuroendocrine Neoplasms. Journal of Clinical Medicine. 2019; 8(10):1611. https://doi.org/10.3390/jcm8101611
Chicago/Turabian StyleAndreasi, Valentina, Stefano Partelli, Gabriele Capurso, Francesca Muffatti, Gianpaolo Balzano, Stefano Crippa, and Massimo Falconi. 2019. "Long-Term Pancreatic Functional Impairment after Surgery for Neuroendocrine Neoplasms" Journal of Clinical Medicine 8, no. 10: 1611. https://doi.org/10.3390/jcm8101611
APA StyleAndreasi, V., Partelli, S., Capurso, G., Muffatti, F., Balzano, G., Crippa, S., & Falconi, M. (2019). Long-Term Pancreatic Functional Impairment after Surgery for Neuroendocrine Neoplasms. Journal of Clinical Medicine, 8(10), 1611. https://doi.org/10.3390/jcm8101611