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Proteomic Analysis of Longitudinal Changes in Blood Pressure

Department of Medical Sciences, Uppsala University, 75236 Uppsala, Sweden
Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA
Stanford Diabetes Research Center, Stanford University, Stanford, CA 94305, USA
Division of Family Medicine and Primary Care, Department of Neurobiology, Care Science and Society, Karolinska Institutet, 14152 Huddinge, Sweden
School of Health and Social Studies, Dalarna University, 79131 Falun, Sweden
Department of Clinical Sciences, Cardiovascular Epidemiology, Lund University, 21428 Malmö, Sweden
The George Institute for Global Health, University of New South Wales, Sydney 2042, Australia
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1585;
Received: 8 August 2019 / Revised: 16 September 2019 / Accepted: 30 September 2019 / Published: 2 October 2019
(This article belongs to the Section Cardiology)
Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline circulating protein levels assessed with a proximity extension assay and BP stage progression at follow-up 5 years later among persons without BP-lowering drugs at baseline in two independent community-based cohorts from the Prospective Investigation of the Vasculature in Uppsala Seniors study (PIVUS) and the Uppsala Longitudinal Study of Adult Men (ULSAM). We used an independent cohort, the Malmö Diet and Cancer Study (MDC), for replication. The primary outcome of BP stage progression was defined as per the 2017 AHA/ACC (American Heart Association/ American College of Cardiology) Guideline BP categories. We also investigated associations of protein levels with changes in BP on a continuous scale, and meta-analyzed all three cohorts. Levels of renin were associated with BP stage progression with a 5% false discovery rate (FDR) in the ULSAM (n = 238) and PIVUS (n = 566) cohorts, but we could not replicate this association in the MDC cohort (n = 2659). The association in the discovery cohorts was modest, with an odds ratio for BP stage progression over 5 years of 1.33 (95% confidence interval 1.14 to 1.56) per standard deviation of baseline renin. In conclusion, we could not find any novel robust associations with longitudinal BP increase in a proximity extension assay-based proteomics investigation in three cohorts. View Full-Text
Keywords: proteomics; blood pressure; hypertension; prospective cohort proteomics; blood pressure; hypertension; prospective cohort
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MDPI and ACS Style

Lin, Y.-T.; Fall, T.; Hammar, U.; Gustafsson, S.; Ingelsson, E.; Ärnlöv, J.; Lind, L.; Engström, G.; Sundström, J. Proteomic Analysis of Longitudinal Changes in Blood Pressure. J. Clin. Med. 2019, 8, 1585.

AMA Style

Lin Y-T, Fall T, Hammar U, Gustafsson S, Ingelsson E, Ärnlöv J, Lind L, Engström G, Sundström J. Proteomic Analysis of Longitudinal Changes in Blood Pressure. Journal of Clinical Medicine. 2019; 8(10):1585.

Chicago/Turabian Style

Lin, Yi-Ting, Tove Fall, Ulf Hammar, Stefan Gustafsson, Erik Ingelsson, Johan Ärnlöv, Lars Lind, Gunnar Engström, and Johan Sundström. 2019. "Proteomic Analysis of Longitudinal Changes in Blood Pressure" Journal of Clinical Medicine 8, no. 10: 1585.

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