Next Article in Journal
Intraoperative Fluid Restriction is Associated with Functional Delayed Graft Function in Living Donor Kidney Transplantation: A Retrospective Cohort Analysis
Previous Article in Journal
Has The Time Arrived to Refine The Indications of Immunosuppressive Therapy and Prognosis in IgA Nephropathy?
Open AccessArticle

Proteomic Analysis of Longitudinal Changes in Blood Pressure

1
Department of Medical Sciences, Uppsala University, 75236 Uppsala, Sweden
2
Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan
3
Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
4
Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA
5
Stanford Diabetes Research Center, Stanford University, Stanford, CA 94305, USA
6
Division of Family Medicine and Primary Care, Department of Neurobiology, Care Science and Society, Karolinska Institutet, 14152 Huddinge, Sweden
7
School of Health and Social Studies, Dalarna University, 79131 Falun, Sweden
8
Department of Clinical Sciences, Cardiovascular Epidemiology, Lund University, 21428 Malmö, Sweden
9
The George Institute for Global Health, University of New South Wales, Sydney 2042, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1585; https://doi.org/10.3390/jcm8101585
Received: 8 August 2019 / Revised: 16 September 2019 / Accepted: 30 September 2019 / Published: 2 October 2019
(This article belongs to the Section Cardiology)
Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline circulating protein levels assessed with a proximity extension assay and BP stage progression at follow-up 5 years later among persons without BP-lowering drugs at baseline in two independent community-based cohorts from the Prospective Investigation of the Vasculature in Uppsala Seniors study (PIVUS) and the Uppsala Longitudinal Study of Adult Men (ULSAM). We used an independent cohort, the Malmö Diet and Cancer Study (MDC), for replication. The primary outcome of BP stage progression was defined as per the 2017 AHA/ACC (American Heart Association/ American College of Cardiology) Guideline BP categories. We also investigated associations of protein levels with changes in BP on a continuous scale, and meta-analyzed all three cohorts. Levels of renin were associated with BP stage progression with a 5% false discovery rate (FDR) in the ULSAM (n = 238) and PIVUS (n = 566) cohorts, but we could not replicate this association in the MDC cohort (n = 2659). The association in the discovery cohorts was modest, with an odds ratio for BP stage progression over 5 years of 1.33 (95% confidence interval 1.14 to 1.56) per standard deviation of baseline renin. In conclusion, we could not find any novel robust associations with longitudinal BP increase in a proximity extension assay-based proteomics investigation in three cohorts. View Full-Text
Keywords: proteomics; blood pressure; hypertension; prospective cohort proteomics; blood pressure; hypertension; prospective cohort
Show Figures

Graphical abstract

MDPI and ACS Style

Lin, Y.-T.; Fall, T.; Hammar, U.; Gustafsson, S.; Ingelsson, E.; Ärnlöv, J.; Lind, L.; Engström, G.; Sundström, J. Proteomic Analysis of Longitudinal Changes in Blood Pressure. J. Clin. Med. 2019, 8, 1585.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop