Next Article in Journal
The Error of Estimated GFR in Type 2 Diabetes Mellitus
Next Article in Special Issue
Iduronate-2-Sulfatase-Regulated Dermatan Sulfate Levels Potentiate the Invasion of Breast Cancer Epithelia through Collagen Matrix
Previous Article in Journal
Heat Generation at the Implant–Bone Interface by Insertion of Ceramic and Titanium Implants
Previous Article in Special Issue
A Novel Ex Vivo System Using 3D Polymer Scaffold to Culture Circulating Tumor Cells from Breast Cancer Patients Exhibits Dynamic E-M Phenotypes
Review

Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression

1
Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore 560012, India
2
Cancer Research Program, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1542; https://doi.org/10.3390/jcm8101542
Received: 30 July 2019 / Revised: 20 September 2019 / Accepted: 23 September 2019 / Published: 25 September 2019
Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to genetic heterogeneity, a consequence of mutational events, phenotypic heterogeneity arises from dynamic, reversible cell state transitions in response to varying intracellular/extracellular signals. Such phenotypic plasticity enables rapid adaptive responses to various stressful conditions and can have a strong impact on cancer progression. Herein, we have reviewed relevant literature on mechanisms associated with dynamic phenotypic changes and cellular plasticity, such as epithelial–mesenchymal transition (EMT) and cancer stemness, which have been reported to facilitate cancer metastasis. We also discuss how non-cell-autonomous mechanisms such as cell–cell communication can lead to an emergent population-level response in tumors. The molecular mechanisms underlying the complexity of tumor systems are crucial for comprehending cancer progression, and may provide new avenues for designing therapeutic strategies. View Full-Text
Keywords: cellular dynamics; epithelial-to-mesenchymal transition; cell plasticity; cancer stem cells; mathematical modeling; population homeostasis cellular dynamics; epithelial-to-mesenchymal transition; cell plasticity; cancer stem cells; mathematical modeling; population homeostasis
Show Figures

Figure 1

MDPI and ACS Style

Jolly, M.K.; Celià-Terrassa, T. Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression. J. Clin. Med. 2019, 8, 1542. https://doi.org/10.3390/jcm8101542

AMA Style

Jolly MK, Celià-Terrassa T. Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression. Journal of Clinical Medicine. 2019; 8(10):1542. https://doi.org/10.3390/jcm8101542

Chicago/Turabian Style

Jolly, Mohit Kumar, and Toni Celià-Terrassa. 2019. "Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression" Journal of Clinical Medicine 8, no. 10: 1542. https://doi.org/10.3390/jcm8101542

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop