Next Article in Journal
Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables
Previous Article in Journal
Influence of Shoe Characteristics on the Development of Valgus Foot in Children
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
J. Clin. Med. 2019, 8(1), 86; https://doi.org/10.3390/jcm8010086

Increased Systemic Malondialdehyde Levels and Decreased Mo/Co, Co/Fe2+ Ratios in Patients with Long-Term Dental Titanium Implants and Amalgams

1
Centro CIROM, Centro de Implantología y Rehabilitación Oral Multidisciplinaria, 30001 Murcia, Spain
2
Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
3
Hospital General Universitario Morales Meseguer, University of Murcia, 30100 Murcia, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equal to this work.
Received: 21 November 2018 / Revised: 19 December 2018 / Accepted: 2 January 2019 / Published: 12 January 2019
(This article belongs to the Section Orthopedics)
Full-Text   |   PDF [1045 KB, uploaded 24 January 2019]   |  

Abstract

Introduction: the biological safety of dental biomaterials has been questioned in human studies. Material and Methods: Several heavy metals/oligoelements were compared by Inductive Coupled Mass Spectrometry (ICP-MS) in hair samples from 130 patients (n = 54 patients with long-term titanium dental implants and amalgams (A + I group), 51 patients with long-term dental amalgam alone (A group), as well as controls (n = 25: without dental materials) of similar age. All patients (except controls) had had titanium dental implants and/or dental amalgams for at least 10 years (average: 17). We evaluated whether A + I patients could present higher systemic malondialdehyde levels (MDA) as compared to the A group. Results: The A + I group have lower molybdenum levels (A + I) and reduced Mo/Co and Mo/Fe2+ ratios, which could predispose them to oxidative stress by raising MDA levels as compared to the A group alone; our findings suggest that higher Co levels could enhance oxidative stress in the A + I group. However, there were no differences on metals from titanium alloy (Ti-6Al), Cr from crowns or Hg2+, Sn, Zn2+, Cu2+ levels between the A + I and A groups. Conclusion: patients with long-term dental titanium and amalgams have systemic oxidative stress due to rising MDA levels and lower Mo/Co and Mo/Fe2+ ratios than those with amalgams alone. View Full-Text
Keywords: toxicology of heavy metals; oligoelements; molybdenum (Mo), titanium (Ti); mercury, lipoperoxides (MDA); oxidative stress; free radicals and medicine; dental amalgams and titanium implants toxicology of heavy metals; oligoelements; molybdenum (Mo), titanium (Ti); mercury, lipoperoxides (MDA); oxidative stress; free radicals and medicine; dental amalgams and titanium implants
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Cabaña-Muñoz, M.E.; Parmigiani-Izquierdo, J.M.; Camacho Alonso, F.; Merino, J.J. Increased Systemic Malondialdehyde Levels and Decreased Mo/Co, Co/Fe2+ Ratios in Patients with Long-Term Dental Titanium Implants and Amalgams. J. Clin. Med. 2019, 8, 86.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top