Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon
AbstractThe aim of the present study was to examine the acute effect of an ultra-endurance performance on N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac specific troponin T (cTnT), creatinine kinase-myocardial band (CK-MB), high sensitive C-reactive protein (hsCRP), ischemia modified albumin (IMA), heart-type fatty acid binding protein (H-FABP) and cardiovascular function. Cardiac biomarkers were evaluated in 14 male ultra-marathoners (age 40 ± 12 years) during a 24 h ultra-marathon at five points (i.e., Pre-race; Marathon, 12-h run, 24-h run, and 48-h post-race). All subjects underwent baseline echocardiography assessment at least 10 days prior to the ultra-marathon and 48 h post-race. The average distance covered during the race was 149.4 ± 33.0 km. Running the ultra-marathon led to a progressive increase in hsCRP and H-FABP concentrations (p < 0.001). CK-MB and cTnT levels were higher after a 24-h run compared to pre-race (p < 0.05). Diastolic function was altered post-race characterized by a reduction in peak early to late diastolic filling (p < 0.01). Running an ultra-marathon significantly stimulates specific cardiac biomarkers; however, the dynamic of secretion of biomarkers linked to myocardium ischemia were differentially regulated during the ultra-marathon race. It is suggested that both exercise duration and intensity play a crucial role in cardiovascular adaptive mechanisms and cause risk of cardiac stress in ultra-marathoners. View Full-Text
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Żebrowska, A.; Waśkiewicz, Z.; Nikolaidis, P.T.; Mikołajczyk, R.; Kawecki, D.; Rosemann, T.; Knechtle, B. Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon. J. Clin. Med. 2019, 8, 57.
Żebrowska A, Waśkiewicz Z, Nikolaidis PT, Mikołajczyk R, Kawecki D, Rosemann T, Knechtle B. Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon. Journal of Clinical Medicine. 2019; 8(1):57.Chicago/Turabian Style
Żebrowska, Aleksandra; Waśkiewicz, Zbigniew; Nikolaidis, Pantelis T.; Mikołajczyk, Rafał; Kawecki, Damian; Rosemann, Thomas; Knechtle, Beat. 2019. "Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon." J. Clin. Med. 8, no. 1: 57.
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