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Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon

Department of Physiological and Medical Sciences, Academy of Physical Education, Mikołowska Street 72a, 40-065 Katowice, Poland
Department of Team Sports Games, Academy of Physical Education in Katowice, Mikołowska Street 72a, 40-065 Katowice, Poland
Department of Sports Medicine and Medical Rehabilitation, Sechenov University, Moscow 119991, Russia
Laboratory of Exercise Testing, Hellenic Air Force Academy, Dekelia, Thermopylon 7, 18450 Nikaia, Greece
Second Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Skłodowskiej, Curie 10 Street, 41-800 Zabrze, Poland
Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland
Medbase St. Gallen Am Vadianplatz, 9001 St. Gallen, Switzerland
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(1), 57;
Received: 1 December 2018 / Revised: 31 December 2018 / Accepted: 1 January 2019 / Published: 8 January 2019
(This article belongs to the Section Cardiology)
The aim of the present study was to examine the acute effect of an ultra-endurance performance on N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac specific troponin T (cTnT), creatinine kinase-myocardial band (CK-MB), high sensitive C-reactive protein (hsCRP), ischemia modified albumin (IMA), heart-type fatty acid binding protein (H-FABP) and cardiovascular function. Cardiac biomarkers were evaluated in 14 male ultra-marathoners (age 40 ± 12 years) during a 24 h ultra-marathon at five points (i.e., Pre-race; Marathon, 12-h run, 24-h run, and 48-h post-race). All subjects underwent baseline echocardiography assessment at least 10 days prior to the ultra-marathon and 48 h post-race. The average distance covered during the race was 149.4 ± 33.0 km. Running the ultra-marathon led to a progressive increase in hsCRP and H-FABP concentrations (p < 0.001). CK-MB and cTnT levels were higher after a 24-h run compared to pre-race (p < 0.05). Diastolic function was altered post-race characterized by a reduction in peak early to late diastolic filling (p < 0.01). Running an ultra-marathon significantly stimulates specific cardiac biomarkers; however, the dynamic of secretion of biomarkers linked to myocardium ischemia were differentially regulated during the ultra-marathon race. It is suggested that both exercise duration and intensity play a crucial role in cardiovascular adaptive mechanisms and cause risk of cardiac stress in ultra-marathoners. View Full-Text
Keywords: human performance; myocardium ischemia; ultra-endurance human performance; myocardium ischemia; ultra-endurance
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Żebrowska, A.; Waśkiewicz, Z.; Nikolaidis, P.T.; Mikołajczyk, R.; Kawecki, D.; Rosemann, T.; Knechtle, B. Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon. J. Clin. Med. 2019, 8, 57.

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