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J. Clin. Med. 2019, 8(1), 57; https://doi.org/10.3390/jcm8010057

Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon

1
Department of Physiological and Medical Sciences, Academy of Physical Education, Mikołowska Street 72a, 40-065 Katowice, Poland
2
Department of Team Sports Games, Academy of Physical Education in Katowice, Mikołowska Street 72a, 40-065 Katowice, Poland
3
Department of Sports Medicine and Medical Rehabilitation, Sechenov University, Moscow 119991, Russia
4
Laboratory of Exercise Testing, Hellenic Air Force Academy, Dekelia, Thermopylon 7, 18450 Nikaia, Greece
5
Second Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Skłodowskiej, Curie 10 Street, 41-800 Zabrze, Poland
6
Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland
7
Medbase St. Gallen Am Vadianplatz, 9001 St. Gallen, Switzerland
*
Author to whom correspondence should be addressed.
Received: 1 December 2018 / Revised: 31 December 2018 / Accepted: 1 January 2019 / Published: 8 January 2019
(This article belongs to the Section Cardiology)
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Abstract

The aim of the present study was to examine the acute effect of an ultra-endurance performance on N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac specific troponin T (cTnT), creatinine kinase-myocardial band (CK-MB), high sensitive C-reactive protein (hsCRP), ischemia modified albumin (IMA), heart-type fatty acid binding protein (H-FABP) and cardiovascular function. Cardiac biomarkers were evaluated in 14 male ultra-marathoners (age 40 ± 12 years) during a 24 h ultra-marathon at five points (i.e., Pre-race; Marathon, 12-h run, 24-h run, and 48-h post-race). All subjects underwent baseline echocardiography assessment at least 10 days prior to the ultra-marathon and 48 h post-race. The average distance covered during the race was 149.4 ± 33.0 km. Running the ultra-marathon led to a progressive increase in hsCRP and H-FABP concentrations (p < 0.001). CK-MB and cTnT levels were higher after a 24-h run compared to pre-race (p < 0.05). Diastolic function was altered post-race characterized by a reduction in peak early to late diastolic filling (p < 0.01). Running an ultra-marathon significantly stimulates specific cardiac biomarkers; however, the dynamic of secretion of biomarkers linked to myocardium ischemia were differentially regulated during the ultra-marathon race. It is suggested that both exercise duration and intensity play a crucial role in cardiovascular adaptive mechanisms and cause risk of cardiac stress in ultra-marathoners. View Full-Text
Keywords: human performance; myocardium ischemia; ultra-endurance human performance; myocardium ischemia; ultra-endurance
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MDPI and ACS Style

Żebrowska, A.; Waśkiewicz, Z.; Nikolaidis, P.T.; Mikołajczyk, R.; Kawecki, D.; Rosemann, T.; Knechtle, B. Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon. J. Clin. Med. 2019, 8, 57.

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