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Open AccessArticle

The Association of Insomnia, Perceived Immune Functioning, and Irritable Bowel Syndrome Complaints

1
Division of Pharmacology, Utrecht University, 3584CG Utrecht, The Netherlands
2
Faculty of Behavioural and Social Sciences, Groningen University, 9712TS Groningen, The Netherlands
3
Nutricia Research, 3584CT Utrecht, The Netherlands
4
Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584CM Utrecht, The Netherlands
5
Sleep Disorders & Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
6
Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(9), 238; https://doi.org/10.3390/jcm7090238
Received: 27 June 2018 / Accepted: 22 August 2018 / Published: 24 August 2018
(This article belongs to the Section Gastroenterology & Hepato-Pancreato-Biliary Medicine)
Background: Irritable bowel syndrome (IBS) can have a significant negative impact on quality of life, mood and wellbeing. The aim of this study was to investigate the association between experiencing IBS symptoms and insomnia, and perceived health status. Method: An online survey was conducted among n = 1950 Dutch university students (83.6% women). IBS was assessed with the Birmingham IBS Symptom Questionnaire, quality of life with the WHO-5 wellbeing index, and sleep outcomes with the SLEEP-50 questionnaire. Perceived immune functioning and general health were assessed using 1-item scales. Results: IBS symptom severity was significantly associated with insomnia complaints (r = 0.32, p = 0.0001), sleep quality (r = −0.21, p = 0.0001), sleep onset latency (r = 0.11, p = 0.0001) and the number of nightly awakenings (r = 0.24, p = 0.0001). Total sleep time was not significantly associated with IBS symptom severity. Significant correlations were also found between IBS symptom severity and perceived general health (r = −0.30, p = 0.0001), perceived immune functioning (r= −0.25, p = 0.0001), and quality of life (r = −0.24, p = 0.0001). Conclusions: Experiencing IBS complaints is associated with reduced perceived immune functioning, a poorer perception of general health, and sleep disturbances. These effects are reflected in a significantly lower reported quality of life in subjects with more IBS and/or sleep complaints. View Full-Text
Keywords: irritable bowel syndrome; sleep; insomnia; perceived immune functioning; quality of life irritable bowel syndrome; sleep; insomnia; perceived immune functioning; quality of life
MDPI and ACS Style

Balikji, S.; Mackus, M.; Brookhuis, K.A.; Garssen, J.; Kraneveld, A.D.; Roth, T.; Verster, J.C. The Association of Insomnia, Perceived Immune Functioning, and Irritable Bowel Syndrome Complaints. J. Clin. Med. 2018, 7, 238.

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