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Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target

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Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA 91010, USA
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Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA
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Division of Urology and Urologic Oncology, City of Hope, Duarte, CA 91010, USA
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Department of Physics, North Carolina State University, Raleigh, NC 27695, USA
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Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA
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Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(6), 156; https://doi.org/10.3390/jcm7060156
Received: 31 May 2018 / Revised: 13 June 2018 / Accepted: 15 June 2018 / Published: 17 June 2018
(This article belongs to the Section Molecular Medicine)
Prostate cancer (PCa) is a leading cause of mortality and morbidity globally. While genomic alterations have been identified in PCa, in contrast to some other cancers, use of such information to personalize treatment is still in its infancy. Here, we discuss how PAGE4, a protein which appears to act both as an oncogenic factor as well as a metastasis suppressor, is a novel therapeutic target for PCa. Inhibiting PAGE4 may be a viable strategy for low-risk PCa where it is highly upregulated. Conversely, PAGE4 expression is downregulated in metastatic PCa and, therefore, reinstituting its sustained expression may be a promising option to subvert or attenuate androgen-resistant PCa. Thus, fine-tuning the levels of PAGE4 may represent a novel approach for personalized medicine in PCa. View Full-Text
Keywords: PAGE4; prostate cancer; symptomatic BPH; Cancer/Testis Antigen; ADT; IAD PAGE4; prostate cancer; symptomatic BPH; Cancer/Testis Antigen; ADT; IAD
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Salgia, R.; Jolly, M.K.; Dorff, T.; Lau, C.; Weninger, K.; Orban, J.; Kulkarni, P. Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target. J. Clin. Med. 2018, 7, 156.

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