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Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1

Department of Pharmacy, Sunchon National University, Jeonnam, Suncheon 57922, Korea
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul 08826, Korea
Authors to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(6), 154;
Received: 30 May 2018 / Accepted: 10 June 2018 / Published: 15 June 2018
(This article belongs to the Section Molecular Medicine)
Osteoporosis is a disease characterized by osteoclast-mediated low bone mass. The modulation of osteoclasts is important for the prevention or therapeutic treatment of loss of bone mass. Osteoclasts, which are bone-resorbing multinucleated cells, are differentiated from the hematopoietic stem cell monocyte/macrophage lineage by Receptor activator of nuclear factor kappa-B ligand (RANKL) expressed from osteoblasts and stromal cells. RANKL signaling ultimately activates nuclear factor of activated T Cells 1 (NFATc1), which is a master transcription factor in osteoclastogenesis. Betulin, a lupine type pentacyclic triterpenoid, was isolated from the bark of Betula platyphylla. Betulin inhibited RANKL-mediated osteoclast differentiation by downregulating NFATc1. Betulin may serve as a useful structural scaffold in the therapeutic agent development to prevention/treatment the osteoclast-mediated bone disorder. View Full-Text
Keywords: bone; osteoporosis; osteoclast; RANKL; NFATc1; betulin; natural product; Betula platyphylla bone; osteoporosis; osteoclast; RANKL; NFATc1; betulin; natural product; Betula platyphylla
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Kim, K.-J.; Lee, Y.; Hwang, H.-G.; Sung, S.H.; Lee, M.; Son, Y.-J. Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1. J. Clin. Med. 2018, 7, 154.

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