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Open AccessArticle

The High-Sensitivity C-Reactive Protein/Albumin Ratio Predicts Long-Term Oncologic Outcomes after Curative Resection for Hepatocellular Carcinoma

1
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, 166 Gumi-ro, Bundang-gu, Seongnam 13620, Korea
2
Department of Surgery, Seoul National University Bundang Hospital, Seongnam, 166 Gumi-ro, Bundang-gu, Seongnam 13620, Korea
3
Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(6), 139; https://doi.org/10.3390/jcm7060139
Received: 4 May 2018 / Revised: 31 May 2018 / Accepted: 6 June 2018 / Published: 7 June 2018
(This article belongs to the Section Molecular Diagnostics)
High-sensitivity C-reactive protein (hsCRP) is a prognostic factor for hepatocellular carcinoma (HCC), while albumin is known to be a disease severity index of the malnutrition status in HCC patients. The present study investigated the association between postoperative hsCRP/albumin ratio and both overall survival (OS) and recurrence-free survival (RFS) following HCC surgery. This retrospective observational study examined the medical records of 389 patients who underwent resection for HCC between 2004 and 2013. Postoperative day 0–1 hsCRP/albumin ratio was collected, and the optimal postoperative mortality cut-off point was derived using receiver operating characteristics (ROC) analysis. A postoperative hsCRP/albumin ratio increase of 1.0 was associated with a 1.171-fold increase in mortality (hazard ratio (HR): 1.171, 95% confidence interval (CI): 1.072–1.278, p < 0.001) and a 1.19-fold increase in recurrence (HR: 1.190, 95% CI: 1.108–1.278, p < 0.001). The hsCRP/albumin ratio cut-off point was found to be 0.625 and 0.500. When patients were grouped by this cut-off point, the >0.625 group showed a 2.257-fold increase in mortality (HR: 2.257, 95% CI: 1.470–3.466, p < 0.001), and the >0.500 group showed a 1.518-fold increase in recurrence (HR: 1.518, 95% CI: 1.125–2.050, p = 0.006). View Full-Text
Keywords: hepatobiliary-surg; prognostic factor; surgery hepatobiliary-surg; prognostic factor; surgery
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Oh, T.K.; Choi, Y.-R.; Cho, J.Y.; Yoon, Y.-S.; Han, H.-S.; Park, I.S.; Ryu, J.-H. The High-Sensitivity C-Reactive Protein/Albumin Ratio Predicts Long-Term Oncologic Outcomes after Curative Resection for Hepatocellular Carcinoma. J. Clin. Med. 2018, 7, 139.

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