Next Article in Journal
Efficacy of Denosumab for Osteoporosis in Two Patients with Adult-Onset Still’s Disease—Denosumab Efficacy in Osteoporotic Still’s Disease Patients
Previous Article in Journal
Epigenetic Modifications in Thyroid Cancer Cells Restore NIS and Radio-Iodine Uptake and Promote Cell Death
Open AccessFeature PaperEditor’s ChoiceReview

Novel Indications for Bruton’s Tyrosine Kinase Inhibitors, beyond Hematological Malignancies

by Robert Campbell 1,2, Geoffrey Chong 1,3,4 and Eliza A. Hawkes 1,5,6,*
Department of Medical Oncology and Clinical Haematology, Olivia Newton-John Cancer Research Institute, Austin Health, Heidelberg, VIC 3084, Australia
Bendigo Cancer Centre, Bendigo Health, Bendigo, VIC 3084, Australia
Department of Oncology, Northern Hospital, Melbourne, VIC 3084, Australia
Department of Medical Oncology, Ballarat Health Services, Ballarat, VIC 3084, Australia
Department of Medical Oncology, Eastern Health, Melbourne, VIC 3084, Australia
Eastern Health, Monash University Clinical School, Melbourne, VIC 3084, Australia
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(4), 62;
Received: 31 December 2017 / Revised: 18 February 2018 / Accepted: 6 March 2018 / Published: 21 March 2018
(This article belongs to the Section Hematology)
Bruton’s tyrosine kinase (BTK) is a critical terminal enzyme in the B-cell antigen receptor (BCR) pathway. BTK activation has been implicated in the pathogenesis of certain B-cell malignancies. Targeting this pathway has emerged as a novel target in B-cell malignancies, of which ibrutinib is the first-in-class agent. A few other BTK inhibitors (BTKi) are also under development (e.g., acalabrutinib). While the predominant action of BTKi is the blockade of B-cell receptor pathway within malignant B-cells, increasing the knowledge of off-target effects as well as a potential role for B-cells in proliferation of solid malignancies is expanding the indication of BTKi into non-hematological malignancies. In addition to the expansion of the role of BTKi monotherapy, combination therapy strategies utilizing ibrutinib with established regimens and combination with modern immunotherapy compounds are being explored. View Full-Text
Keywords: ibrutinib; Bruton’s tyrosine kinase; solid tumors ibrutinib; Bruton’s tyrosine kinase; solid tumors
Show Figures

Figure A1

MDPI and ACS Style

Campbell, R.; Chong, G.; Hawkes, E.A. Novel Indications for Bruton’s Tyrosine Kinase Inhibitors, beyond Hematological Malignancies. J. Clin. Med. 2018, 7, 62.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop