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Article

Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?

1
Faculty of Health, University of Canberra, Bruce, ACT 2617, Australia
2
School of Medicine, University of Tasmania, Sandy Bay, TAS 7005, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(12), 533; https://doi.org/10.3390/jcm7120533
Received: 7 November 2018 / Revised: 30 November 2018 / Accepted: 7 December 2018 / Published: 10 December 2018
(This article belongs to the Section Pharmacology)
The prolongation of the QT interval is a relatively rare but serious adverse drug reaction. It can lead to torsade de pointes, which is potentially life-threatening. The study’s objectives were: determine the use of QT interval-prolonging drugs in an elderly community-dwelling population at risk of medication misadventure and identify recommendations regarding the risk of QT interval prolongation made by pharmacists when performing medication reviews. In a retrospective evaluation, 500 medication review reports from Australian pharmacists were analysed. In patients taking at least one QT interval-prolonging drug, the individual risk of drug-induced QT interval prolongation was assessed. Recommendations of pharmacists to avoid the occurrence of this drug-related problem were examined. There was a high prevalence of use of potentially QT interval-prolonging drugs (71% patients), with 11% of patients taking at least one drug with a known risk. Pharmacists provided specific recommendations in only eight out of 35 patients (23%) with a high-risk score and taking drugs with known risk of QT interval prolongation. Pharmacists’ recommendations, when present, were focused on drugs with known risk of QT interval prolongation, rather than patients’ additional risk factors. There is a need to improve knowledge and awareness of this topic among pharmacists performing medication reviews. View Full-Text
Keywords: QT interval prolongation; torsade de pointes; medication review; pharmacist intervention QT interval prolongation; torsade de pointes; medication review; pharmacist intervention
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MDPI and ACS Style

Buss, V.H.; Lee, K.; Naunton, M.; Peterson, G.M.; Kosari, S. Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity? J. Clin. Med. 2018, 7, 533. https://doi.org/10.3390/jcm7120533

AMA Style

Buss VH, Lee K, Naunton M, Peterson GM, Kosari S. Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity? Journal of Clinical Medicine. 2018; 7(12):533. https://doi.org/10.3390/jcm7120533

Chicago/Turabian Style

Buss, Vera H., Kayla Lee, Mark Naunton, Gregory M. Peterson, and Sam Kosari. 2018. "Identification of Patients At-Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?" Journal of Clinical Medicine 7, no. 12: 533. https://doi.org/10.3390/jcm7120533

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