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Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

1
Department of Education, Faculty of Education Sciences, University of Almería, 04120 Almería, Spain
2
SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, 04120 Almería, Spain
3
Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain
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Systemic Autoimmune Diseases Unit, Department of Internal Medicine, “Virgen de las Nieves” University Hospital, 18014 Granada, Spain
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Service of Endocrinology, La Mancha Centro Hospital, 13071 Ciudad Real, Spain
6
Systemic Autoimmune Diseases Unit, Department of Internal Medicine, “San Cecilio” University Hospital, 18012 Granada, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(12), 477; https://doi.org/10.3390/jcm7120477
Received: 2 November 2018 / Revised: 20 November 2018 / Accepted: 21 November 2018 / Published: 24 November 2018
(This article belongs to the Section Immunology)
This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions × 75 min/week) between 40–75% of the individual’s heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN-α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference −0.034, 95% CI −0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE. View Full-Text
Keywords: exercise; physical fitness; aerobic fitness; physical function; pulse wave velocity; autoimmune diseases; vascular health; atherosclerosis; lupus; inflammatory disease exercise; physical fitness; aerobic fitness; physical function; pulse wave velocity; autoimmune diseases; vascular health; atherosclerosis; lupus; inflammatory disease
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MDPI and ACS Style

Soriano-Maldonado, A.; Morillas-de-Laguno, P.; Sabio, J.M.; Gavilán-Carrera, B.; Rosales-Castillo, A.; Montalbán-Méndez, C.; Sáez-Urán, L.M.; Callejas-Rubio, J.L.; Vargas-Hitos, J.A. Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial. J. Clin. Med. 2018, 7, 477. https://doi.org/10.3390/jcm7120477

AMA Style

Soriano-Maldonado A, Morillas-de-Laguno P, Sabio JM, Gavilán-Carrera B, Rosales-Castillo A, Montalbán-Méndez C, Sáez-Urán LM, Callejas-Rubio JL, Vargas-Hitos JA. Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial. Journal of Clinical Medicine. 2018; 7(12):477. https://doi.org/10.3390/jcm7120477

Chicago/Turabian Style

Soriano-Maldonado, Alberto, Pablo Morillas-de-Laguno, José M. Sabio, Blanca Gavilán-Carrera, Antonio Rosales-Castillo, Cristina Montalbán-Méndez, Luis M. Sáez-Urán, José L. Callejas-Rubio, and José A. Vargas-Hitos 2018. "Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial" Journal of Clinical Medicine 7, no. 12: 477. https://doi.org/10.3390/jcm7120477

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