Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity
Department of Biology, Hampden-Sydney College, Hampden-Sydney, VA 23943, USA
Academic Editor: Andrei Turtoi
J. Clin. Med. 2016, 5(9), 76; https://doi.org/10.3390/jcm5090076
Received: 20 July 2016 / Revised: 26 August 2016 / Accepted: 29 August 2016 / Published: 31 August 2016
(This article belongs to the Special Issue Biological and Clinical Aspects of TGF-beta in Carcinogenesis)
TGFβ1 is a pleiotropic cytokine that exhibits a variety of physiologic and immune regulatory functions. Although its influence on multiple cell types is critical for the regulation of numerous biologic processes in the host, dysregulation of both TGFβ1 expression and activity is frequently observed in cancer and contributes to various aspects of cancer progression. This review focuses on TGFβ1’s contribution to tumor immune suppression and escape, with emphasis on the influence of this regulatory cytokine on the differentiation and function of dendritic cells and T cells. Clinical trials targeting TGFβ1 in cancer patients are also reviewed, and strategies for future therapeutic interventions that build on our current understanding of immune regulation by TGFβ1 are discussed.
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Keywords:
cancer; TGFβ1; dendritic cell; T cell; immune suppression; immunotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Hargadon, K.M. Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity. J. Clin. Med. 2016, 5, 76. https://doi.org/10.3390/jcm5090076
AMA Style
Hargadon KM. Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity. Journal of Clinical Medicine. 2016; 5(9):76. https://doi.org/10.3390/jcm5090076
Chicago/Turabian StyleHargadon, Kristian M. 2016. "Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity" J. Clin. Med. 5, no. 9: 76. https://doi.org/10.3390/jcm5090076
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