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Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis

Division of Surgical Oncology, Department of Surgery, Wexner Medical Center, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
21st Century Oncology, 4571 Colonial Blvd., Suite 210, Fort Myers, FL 33966, USA
Author to whom correspondence should be addressed.
Academic Editor: Rajagopal N. Aravalli
J. Clin. Med. 2016, 5(3), 38;
Received: 20 November 2015 / Revised: 23 February 2016 / Accepted: 7 March 2016 / Published: 16 March 2016
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers for Liver Diseases)
microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in development of hepatic fibrosis and there are intricate regulatory effects of miRNAs on their activation, proliferation, collagen production, migration, and apoptosis. There are multiple differentially expressed miRNAs in activated HSCs, and in this review we aim to summarize current data on miRNAs that participate in the development of hepatic fibrosis. Based on this review, miRNAs may serve as biomarkers for diagnosis of liver disease, as well as markers of disease progression. Most importantly, dysregulated miRNAs may potentially be targeted by novel therapies to treat and reverse progression of hepatic fibrosis. View Full-Text
Keywords: liver disease; microRNA; hepatic stellate cell; liver fibrosis liver disease; microRNA; hepatic stellate cell; liver fibrosis
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Kitano, M.; Bloomston, P.M. Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis. J. Clin. Med. 2016, 5, 38.

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