Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration
Abstract
:1. Introduction
2. Factor H (FH) and the Alternative Complement Pathway
3. Factor H-Related Proteins
4. Genetics of AMD and Functional Implications
5. Tissue Interactions of FH and FHL-1
6. Effects of Aging on Ocular Immunity
7. Complement Based Therapies for AMD
8. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Clark, S.J.; Bishop, P.N. Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration. J. Clin. Med. 2015, 4, 18-31. https://doi.org/10.3390/jcm4010018
Clark SJ, Bishop PN. Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration. Journal of Clinical Medicine. 2015; 4(1):18-31. https://doi.org/10.3390/jcm4010018
Chicago/Turabian StyleClark, Simon J., and Paul N. Bishop. 2015. "Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration" Journal of Clinical Medicine 4, no. 1: 18-31. https://doi.org/10.3390/jcm4010018