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J. Clin. Med. 2014, 3(3), 763-794;

Gut-Brain Endocrine Axes in Weight Regulation and Obesity Pharmacotherapy

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, JAH 368, Philadelphia, PA 19107, USA
Author to whom correspondence should be addressed.
Received: 17 April 2014 / Revised: 29 May 2014 / Accepted: 16 June 2014 / Published: 15 July 2014
(This article belongs to the Special Issue Obesity, Diabetes and Metabolic Syndrome)
Full-Text   |   PDF [298 KB, uploaded 15 July 2014]


In recent years, the obesity epidemic has developed into a major health crisis both in the United States as well as throughout the developed world. With current treatments limited to expensive, high-risk surgery and minimally efficacious pharmacotherapy, new therapeutic options are urgently needed to combat this alarming trend. This review focuses on the endogenous gut-brain signaling axes that regulate appetite under physiological conditions, and discusses their clinical relevance by summarizing the clinical and preclinical studies that have investigated manipulation of these pathways to treat obesity. View Full-Text
Keywords: obesity; satiety; hypothalamus; gut-brain endocrine axis; pharmacotherapy obesity; satiety; hypothalamus; gut-brain endocrine axis; pharmacotherapy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Merlino, D.J.; Blomain, E.S.; Aing, A.S.; Waldman, S.A. Gut-Brain Endocrine Axes in Weight Regulation and Obesity Pharmacotherapy. J. Clin. Med. 2014, 3, 763-794.

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