Next Article in Journal
Prevention of Bone Metastases in Breast Cancer Patients. Therapeutic Perspectives
Next Article in Special Issue
Non-Invasive Prenatal Testing Using Cell Free DNA in Maternal Plasma: Recent Developments and Future Prospects
Previous Article in Journal
Genetic Testing in the Diagnosis of Primary Ciliary Dyskinesia: State-of-the-Art and Future Perspectives
Previous Article in Special Issue
Preimplantation Genetic Diagnosis: Prenatal Testing for Embryos Finally Achieving Its Potential
Open AccessReview

Prenatal Screening Using Maternal Markers

Department of Obstetrics and Gynecology, Columbia University Medical Center, 662 W 168th Street, PH1666, New York, NY 10032-3725, USA
J. Clin. Med. 2014, 3(2), 504-520;
Received: 24 February 2014 / Revised: 28 March 2014 / Accepted: 28 March 2014 / Published: 9 May 2014
(This article belongs to the Special Issue Prenatal Genetic Screening and Diagnosis-Part 1)
Maternal markers are widely used to screen for fetal neural tube defects (NTDs), chromosomal abnormalities and cardiac defects. Some are beginning to broaden prenatal screening to include pregnancy complications such as pre-eclampsia. The methods initially developed for NTDs using a single marker have since been built upon to develop high performance multi-maker tests for chromosomal abnormalities. Although cell-free DNA testing is still too expensive to be considered for routine application in public health settings, it can be cost-effective when used in combination with existing multi-maker marker tests. The established screening methods can be readily applied in the first trimester to identify pregnancies at high risk of pre-eclampsia and offer prevention though aspirin treatment. Prenatal screening for fragile X syndrome might be adopted more widely if the test was to be framed as a form of maternal marker screening. View Full-Text
Keywords: prenatal screening; markers; spina bifida; Down syndrome; pre-eclampsia; fragile X syndrome prenatal screening; markers; spina bifida; Down syndrome; pre-eclampsia; fragile X syndrome
MDPI and ACS Style

Cuckle, H. Prenatal Screening Using Maternal Markers. J. Clin. Med. 2014, 3, 504-520.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop