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Open AccessArticle

Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?

1
Department of Surgery, Leiden University Medical Center, Albinusdreef 2, ZA Leiden 2333, The Netherlands
2
Department of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, ZA Leiden 2333, The Netherlands
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2013, 2(4), 188-200; https://doi.org/10.3390/jcm2040188
Received: 16 August 2013 / Revised: 5 September 2013 / Accepted: 11 September 2013 / Published: 16 October 2013
(This article belongs to the Special Issue Prevention and Treatment of Bone Metastases from Breast Cancer)
The antitumor effect of bisphosphonates (BPs) is under increasing scrutiny. Preclinical and clinical evidence has shown that BPs might sensitize breast tumors to chemotherapy. Here, we present a review of current preclinical and clinical evidence for antitumor effects of BPs, and evaluate how BPs might play a role in neoadjuvant treatment of women with breast cancer. View Full-Text
Keywords: bisphosphonates; zoledronic acid; chemotherapy; neoadjuvant; postmenopausal bisphosphonates; zoledronic acid; chemotherapy; neoadjuvant; postmenopausal
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Charehbili, A.; Fontein, D.B.Y.; Kroep, J.R.; Liefers, G.-J.; Nortier, J.W.R.; Velde, C.J.H. Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy? J. Clin. Med. 2013, 2, 188-200.

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