Improved Cardiometabolic Health with Uterine-Preserving Fibroid Treatment Compared to Hysterectomy
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Population
2.2. Exposure
2.3. Cardiometabolic Outcomes
2.4. Statistical Analysis
3. Results
3.1. Cohort Selection and Demographics
3.2. Descriptive Statistics: Incident Cardiometabolic Case Numbers by Surgical Exposure
3.3. Hysterectomy Compared to No Surgery
3.4. Myomectomy Compared to No Surgery
3.5. Myomectomy Compared to Hysterectomy
3.6. Hysterectomy with Removal of Adnexa Compared to No Surgery
3.7. Hysterectomy with or Without Removal of Adnexal Structures
4. Discussion
Strengths and Weaknesses of the Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
| ICD | International Classification of Diseases |
| CPT | Current Procedural Terminology |
| UAE | Uterine artery embolization |
| T2DM | Type II diabetes |
| CHF | Congestive heart failure |
| CAD | Coronary artery disease |
| U.S. | United States |
| aOR | Age-adjusted odds ratio |
| OR | Odds ratio |
| IQR | Interquartile Range |
| SAS | Statistical Analysis System |
| STROBE | Strengthening the Reporting of Observational Studies in Epidemiology |
Appendix A
| Variable | CPT | ICD9 | ICD10 |
|---|---|---|---|
| Uterine fibroids | 218 | D25 | |
| Hysterectomy | 58294, 58293, 58541, 58275, 58280, 58290, 58267, 58270, 58260, 58570, 58543, 58550, 58572, 58553, 58150, 58292, 58152, 58180, 58542, 58544, 58552, 58554, 58571, 58573, 58262, 58263, 58291 | 68.39, 68.49, 68.31, 68.41, 68.51, 68.4, 68.59 | |
| Hysterectomy—presumed ovarian preserving | 58294, 58293, 58541, 58275, 58280, 58290, 58267, 58270, 58260, 58570, 58543, 58550, 58572, 58553 | ||
| Hysterectomy—with presumed oophorectomy | 58150, 58292, 58152, 58180, 58542, 58544, 58552, 58554, 58571, 58573, 58262, 58263, 58291 | ||
| Myomectomy | 58140–58146 or 58545–58546 | 68.19, 68.29 | |
| Uterine artery embolization | 37204 | ||
| Coronary artery disease | 92920, 92921, 92924, 92925, 92928, 92929, 92933, 92920, 92921, 92924, 92925, 92928, 92929, 92933, 92934, 92937, 92938, 92941, 92973, 92975, 92977, 93454, 93455, 93456, 93457, 93458, 93459, 93460, 93461 | 410, 411, 412, 413, 414 | I20, I21, I22, I23, I24, I25 |
| Congestive heart failure | 428 | I50 | |
| Cardiac arrhythmias | 427 | I46, I47, I48, I49 | |
| Stroke | 37195, 37201, 37202 | 430, 431, 432, 433, 434, 435, 436, 437, 438 | I60, I61, I62, I63, I64, I65, I66, I67, I68, I69 |
| Hypertension | 401, 402, 403, 404, 405 | I10, I11, I12, I13, I15 | |
| Hyperlipidemia | 272 | E780, E781, E782, E783, E784, E785 | |
| Diabetes | 250 | E10, E11, E12, E13, E14 | |
| Obesity | 278 | E66–E68 | |
| Peripheral artery disease | 440, 441, 442, 443, 444, 445 | I70 |
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| No Surgery | Myomectomy | Hysterectomy | p | |
|---|---|---|---|---|
| N = 25,175 | N = 1351 | N = 8196 | ||
| Age, median (IQR) | 45 (40–49) | 39 (35–45) | 45 (41–48) | |
| N (%) | ||||
| Northeast | 4369 (12.6) | 200 (0.6) | 691 (2.0) | <0.001 |
| Northcentral | 4781 (13.8) | 199 (0.6) | 1639 (4.7) | <0.001 |
| South | 13892 (40.0) | 853 (2.4) | 5218 (15.0) | <0.001 |
| West | 2065 (6.0) | 93 (0.2) | 630 (1.8) | 0.03 |
| Unknown | 68 (0.2) | 6 (0.0) | 18 (0.1) | 0.15 |
| OR (95% CI) | p | |
|---|---|---|
| Cardiac Arrhythmia | 1.05 (0.95–1.17) | p = 0.32 |
| Peripheral Artery Disease | 1.03 (0.88–1.20) | p = 0.72 |
| Coronary Artery Disease | 1.21 (1.08–1.36) | p < 0.001 |
| Congestive Heart Failure | 1.03 (0.83–1.23) | p = 0.77 |
| Stroke | 1.15 (1.02–1.30) | p = 0.024 |
| Type II Diabetes | 1.37 (1.25–1.50) | p < 0.001 |
| Hyperlipidemia | 1.28 (1.18–1.38) | p < 0.001 |
| Hypertension | 1.29 (1.19–1.40) | p < 0.001 |
| OR (95% CI) | p | |
|---|---|---|
| Cardiac Arrhythmia | 0.69 (0.47–1.00) | p = 0.06 |
| Peripheral Artery Disease | 1.78 (0.94–3.36) | p = 0.08 |
| Coronary Artery Disease | 0.99 (0.61–1.60) | p = 0.96 |
| Congestive Heart Failure | 1.14 (0.53–2.44) | p = 0.74 |
| Stroke | 1.35 (0.85–2.16) | p = 0.20 |
| Type II Diabetes | 1.38 (0.98–1.93) | p = 0.06 |
| Hyperlipidemia | 1.24 (0.94–1.63) | p = 0.12 |
| Hypertension | 1.06 (0.79–1.4) | p = 0.72 |
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Michel, R.; Kirschen, G.W.; Stukel, C.S.; Olson, S.L.; Yanek, L.; Cameron, K.; Bennett, W.L.; Borahay, M.A. Improved Cardiometabolic Health with Uterine-Preserving Fibroid Treatment Compared to Hysterectomy. J. Clin. Med. 2026, 15, 1960. https://doi.org/10.3390/jcm15051960
Michel R, Kirschen GW, Stukel CS, Olson SL, Yanek L, Cameron K, Bennett WL, Borahay MA. Improved Cardiometabolic Health with Uterine-Preserving Fibroid Treatment Compared to Hysterectomy. Journal of Clinical Medicine. 2026; 15(5):1960. https://doi.org/10.3390/jcm15051960
Chicago/Turabian StyleMichel, Rachel, Gregory W. Kirschen, Caitlin S. Stukel, Sydney L. Olson, Lisa Yanek, Katie Cameron, Wendy L. Bennett, and Mostafa A. Borahay. 2026. "Improved Cardiometabolic Health with Uterine-Preserving Fibroid Treatment Compared to Hysterectomy" Journal of Clinical Medicine 15, no. 5: 1960. https://doi.org/10.3390/jcm15051960
APA StyleMichel, R., Kirschen, G. W., Stukel, C. S., Olson, S. L., Yanek, L., Cameron, K., Bennett, W. L., & Borahay, M. A. (2026). Improved Cardiometabolic Health with Uterine-Preserving Fibroid Treatment Compared to Hysterectomy. Journal of Clinical Medicine, 15(5), 1960. https://doi.org/10.3390/jcm15051960

