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Article

High- and Low-Complexity Features of Non-Critical Adult Patients in the Emergency Department

1
Emergency Department, Local Health Agency of Romagna, Presidio Ospedaliero Morgagni-Pierantoni, Via C Forlanini 34, 47121 Forlì, Italy
2
Department of Computer Science and Engineering, University of Bologna, Mura Anteo Zamboni 7, 40126 Bologna, Italy
3
Department of Mathematical, Physical and Computer Sciences, University of Parma, Parco Area delle Scienze 53/A, 43124 Parma, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2026, 15(3), 1280; https://doi.org/10.3390/jcm15031280
Submission received: 22 December 2025 / Revised: 21 January 2026 / Accepted: 30 January 2026 / Published: 5 February 2026
(This article belongs to the Section Emergency Medicine)

Abstract

Background/Objectives: In the Emergency Department (ED), non-critical patients are classified as Triage Level (TL) 3 on arrival if they are assessed as having a high-level of complexity (HLC), or as TL4–5 if they are assessed as having a low-to-mild level of complexity (LLC). These levels are based on the estimated resources needed. This study aimed to identify the characteristics associated with an HLC or LLC by considering a group of variables from the presentation profile (PP) and clinical diagnostic workload (CDW), assessing ex post whether the assignment of complexity levels based on a priori estimation of the number of resources needed can be considered adequate. Materials and Methods: This retrospective multicentre study involved four first-level EDs and included patients between 2023 and 2024. Outcome Measures: The variables tested in a logistic model were those of the PP (age, sex, chief complaint, National Early Warning Score (NEWS), Numeric Rating Scale (NRS) and those of the CDW (diagnostic tests, interventions and therapy, assistance, and ED length of stay). Results: Of the 335,507 subjects considered, the average age was 59 years (interquartile range [IQR], 25), with 43.3% of cases classified as TL3. An NRS ≥ 7, ECG, urgent laboratory tests, NEWS > 6, need for a stretcher, and male gender were associated with TL3, whereas obstetric–gynaecological complaints, environmental complaints, skin-presenting complaints, and intramuscular therapy were associated with TL4–5. Conclusions: In non-critical patients a defined group of features were associated with different levels of complexity, going beyond the standard criterion based on the resources needed. These results could help clinicians improve the appropriateness of ED care pathways.

1. Introduction

1.1. Background/Rationale

The ED under study utilises the Canadian Triage and Acuity Scale (CTAS), a five-level triage and acuity system that categorises patients by urgency and establishes maximum waiting time targets for initial medical assessment. On this scale, cases defined as ‘critical’ are considered those at TL1 (resuscitation) and TL2 (emergency), while those at TL3 (emergency), TL4 (minor emergency) and TL5 (non-emergency) are considered ‘non-critical’ [1].
Patients defined as non-critical upon arrival usually do not require immediate or urgent life-saving interventions. However, they may present with multiple or severe chronic conditions, atypical or non-specific symptoms, psychosocial problems or functional limitations. These factors can sometimes make assessment and final diagnosis very difficult [2]. These cases are classified upon arrival on the estimated resource needed to complete the clinical diagnostic pathway [3].
High-complexity-level cases (HLC) are those with a high resource demand, while low-level-of-complexity cases (LLC) typically present with a single, clearly defined, minor, or self-limiting problem. The high complexity of Level 3 stems from a complex decision-making process, which considers, for example, pain intensity, age, or comorbidities compared to the primary complaints. Studies highlight the risk of selection bias, especially in crowded settings [4]. Examples of an LLC include a simple minor lesion, an uncomplicated localised infection, or a new medication administration, with a diagnosis that can usually be identified from a limited number of possibilities [5,6].
Under-triage and mis-triage have been associated with an unfavourable outcome [7], whereas over-triage has been linked to overcrowding and unnecessary hospital admissions [8].

1.2. Objectives

This study aimed to identify the characteristics according to the two groups of PP and CDW variables that define an HLC in subjects classified as TL3 and those that define an LLC in subjects classified as TL4–5, thereby assessing ex post whether the assignment of complexity levels based on a priori estimation of pathways can be considered adequate. These findings could inform strategies to improve the appropriateness of ED care pathways.

2. Materials and Methods

2.1. Participants

This is a multicentre and retrospective analysis from digital health records collected from the official registry of the Local Health Agency of Romagna, Italy, between 1 June 2023 and 31 December 2024 (18 consecutive months), including 495,119 encounters/1,172,853 inhabitants, from four 1st-level EDs.
A total of 495,210 consecutive patients registered upon arrival at triage were considered (Figure 1). A total of 159,703 subjects (32.2%) were excluded from the analysis for the following reasons: 63,798 (12.9%) due to critical conditions (TL1-2); 37,047 (7.5%) aged < 18 years; 22,293 (4.5%) because they left the ED without being seen; 21,343 (4.3%) due to intervention errors, e.g., those who left the ED during treatment (LDT); 10,695 (2.2%) cases due to coding errors; 3267 (0.7%) due to registration errors; 1260 (0.2%) due to death during ED stay. Following the selection process, 335,507 cases (67.8% of the total) were analysed comparing TL3 and TL4–5.

2.2. Variables

The PP of patients using the summary statistic was reported in Table 1. The patients’ characteristics included sex and age (by decades) and their NEWS to provide an objective, vital-sign-based assessment that detects early clinical deterioration [9]. In the analyses, the NEWS was reported as a categorical variable (0–4 low risk, 5–6 medium risk, >6 high risk). In the PP, the severity of pain was always included, according to the numerical rating scale (NRS) considered as different categories: 0–3 mild, 4–7 moderate, >7 severe [10]. Incorporating the NRS improves triage levels, ensuring that patients experiencing severe pain are given a higher priority, while reducing reliance on nurses’ judgement alone [11].
The main complaint for the visit was considered using the Canadian Emergency Department Information System (CEDIS) Complaints List (V2.0) classification [12]. All presenting complaints were further divided into two categories (Table 2), traumatic vs. non-traumatic origin.
In order to estimate the CDW, the following were considered as estimated resources required to complete diagnosis and care planning: number of laboratory tests, interventions, and therapy beyond the medical visit. Diagnostic tests and interventions were considered: radiologic imaging (e.g., X-rays), laboratory tests (e.g., blood tests), rapid tests (swab), procedures such as sutures or urinary catheterization, intravenous (IV) or intramuscular (IM) medications (but not oral medications), consultation with specialists, simple or complex interventions (e.g., mild sedation, dressings), intravenous therapy. The following were excluded from the intervention series: oral medications, simple wound care, crutches/splints, prescriptions, and basic anamnesis or physical examination.
The level of assistance was categorised into three levels: ambulatory patients (low-level), wheelchair users (medium-level), and stretcher patients (high-level), with the latter requiring a high CDW. Estimated EDLoS, assuming that a longer stay would require more resources, was also considered in the predictive model for the calculation of the CDW. The time was calculated as the difference between arrival at the ER and the end of the ED pathway (discharge or hospitalisation) and considered as both a continuous and categorical variable (<3 h, 3–6 h, 7–9 h and >9 h).

2.3. Statistical Methods

Data analysis was conducted on a cohort of 335,507 patients. Continuous variables were reported as either the mean (standard deviation, SD) or median [Interquartile range, IQR]. Differences in patient characteristics, along with the corresponding 95% confidence intervals (CIs), were calculated. A p-value of less than 0.05 was considered statistically significant for all analyses. Categorical variables were summarised as counts and percentages.
The NEWS and NRS were considered as continuous and categorical variables.
To account for differences among the subjects, age was divided into decades.
A generalised linear logistic model was developed. Selected variables were determined using the stepwise regression technique. Any multicollinearity arising from procedures in the ED was assessed and considered negligible for the aim of the study, as testing variable selections with alternative methods (e.g., Lasso and Elastic Net) resulted in a larger set of variables in which those exhibiting multicollinearity were still retained. Results were presented as odds ratios (OR) with two-sided 95% confidence intervals (95% CI).
An outcome risk score was computed for each patient based on the coefficients derived from the logistic regression model. The accuracy of this risk score was evaluated by the area under the receiver operating characteristic (ROC) curve. The optimal cutoff point, i.e., the value that maximises both sensitivity and specificity, was determined using the Youden index [13].
To avoid ambiguity, no synthetic data were generated to handle missing data; thus, the analysis relied solely on complete cases. The statistical model was subsequently validated using event–number balancing techniques [14].
Analyses were performed using the Python programming language (version 3.10.12) in Jupyter Notebook. Key libraries included stats models (version 0.13.5), scipy (version 1.10.0), and scikit-learn (version 1.6.0).

3. Results

3.1. Descriptive Data

Table 1 shows the PP variable for the two groups. Males accounted for 50.2% of cases, more represented in the TL4–5 group (51.1%) than in the TL3 group (49.1%). The mean age of the population was 59 years (interquartile range [IQR], 25), higher in the TL3 group than in the TL4–5 group. A comparison between the decades shows a higher prevalence of young people in the TL4–5 group and, conversely, of subjects in the >80 age decades in the TL3 group.
Figure S1 (Supplementary) shows the gender distribution across decades in the TL3 and TL4–5 groups. Males in the TL4–5 group were most common in the 40–60 age group, while in the TL3 group they were most common in the 60–80 age group. In the TL3 group, there was a peak incidence of females in the 80–90 age group.
Subjects with a medium (5–6) and high (>6) NEWS risk score were more represented in the TL3 group, while those at low risk (0–3), as expected, were more represented in the TL4–5 group. In most cases (85%), pain was mild (NRS 0–3). However, more cases were moderate (NRS 4–7) and severe (>NRS 7) in the TL3 group (Table 1).
Table 2 compares chief complaint categories between the two groups, ranked by importance. The main differences between the two groups were in order of importance: environmental, mental health, cardiovascular, cerebral vascular, and the trauma category, which were more represented in the TL3 than in the TL4–5 group.
Table S1 (Supplementary) shows the type and number (%) of resources required for the diagnostic tests and procedures performed on the study population. The most common procedures are blood sampling, ECG, cannulation, swabs, specialist consultation, and urine test strips.
Table S2 (Supplementary) lists the number and frequency of tests and procedures performed in the two groups. Considering the full database, 31.6% of cases did not undergo any tests or interventions, 23.2% underwent one test or intervention, and 22% underwent two or more tests or interventions. A comparison between the two groups shows that TL3 cases require more resources.
Seventy-seven per cent of patients were in an upright position, 5.3% were in a wheelchair, and 17.7% were on a stretcher. An EDLoS < 3 h was more common in the TL4–5 group (35.8%) than in the TL3 group (19.6%; odds ratio (OR) 1.04; 95% confidence interval (CI) 1.03–1.06; p < 0.001). On the other hand, an EDLoS > 3 h was more likely in the TL3 group. Specifically, in the 3–6 h group (39.0% vs. 36.0%) (OR 1.10 95% CI 1.09–1.12, p < 0.001), 6–9 h (23.0% vs. 17.8%); (OR 0.96: 95% CI 0.94–0.97: p < 0.001), >9 h (18.4% vs. 10.4%) (OR 1.03 95% CI 1.01–1.05: p < 0.001).

3.2. Outcome Data

Stepwise feature selection of the PP and CDW groups using a logistic model on randomly under-sampled data revealed a set of variables that entered the model.
Figure 2 lists the variables selected by the stepwise procedure of the logistic model for predicting the TL3 group (upper panel). The main features were, in order of importance, as follows: NRS > 7, electrocardiogram, blood sampling, NEWS > 6, staying on a stretcher, and male gender. For the TL4–5 group (lower panel), the variables selected in order of importance were the categories of gynaecological–obstetric, environmental and skin symptoms, and intramuscular therapy.
The ROC curve for the risk score is shown in Figure 3. The accuracy in identifying the right TLs was 0.816, with a sensitivity of 0.755 and a specificity of 0.735 at the optimal cutoff point (score of 0.437), simultaneously maximising both sensitivity and specificit

4. Discussion

4.1. Key Results

This study identified the characteristics of the PP and CDW associated with an HLC in TL3 subjects and LLC in TL4–5 subjects, which are required to complete the ED clinical diagnostic pathway. Namely, severe pain (NRS > 7), requirement for an ECG, requirement for blood sampling for urgent tests, elevated vital sign risk scores (NEWS > 6), the need for placement on a stretcher, and male gender are associated with HLC features. Disorders related to obstetrics and gynaecology, environmental conditions, dermatology, and intramuscular drug therapy were associated with an LLC.
This study shed light on the current criteria based on the number of resources required, identifying additional characteristics that distinguish between high and low complexity in non-critical cases. Unfortunately, these results cannot be used for a new classification for subjects arriving at triage, as they require both internal and external validation studies [15]. However, these findings provide valuable insights into the current level assignment policy and could inform strategies to enhance the appropriateness of ED care pathways.
In our model, high-severity pain (NRS > 7) at presentation was the main contributor of HLC-associated characteristics, with an increased odds ratio ranging from 2.7 to 3.0. European epidemiological data on chronic and acute pain report that approximately two-thirds of subjects experience moderate pain (NRS 5–7) and only one-third experience severe pain (NRS 8–10) [16]. However, these results may be underestimated, as reported in a Finnish study showing that pain was reported in only 28% of all patients [17].
European guidelines highlight the widespread use of pain assessment in EDs [18], but few data are available on the frequency of cases in the general population and the number of cases referred to the ED. It seems that professionals put more importance on monitoring vital signs, like checking blood pressure or oxygen levels, than on detecting and treating severe pain [19]. In our series, pain on presentation was assessed in 85% of cases. Moderate pain (NRS 4–7) was found in 13.5% of cases and severe pain in only 1.5%. This low percentage could be due to incorrect case detection or the exclusion of critical cases assigned to the very urgent characteristics. Finally, although pain is a key criterion for assignment to the HLC group, our model identifies even a small proportion of cases as the most important factor.
An ECG is a diagnostic test commonly performed in the ED in cases of suspected acute cardiovascular disease, as well as in many other clinical settings [20]. It is estimated that approximately 22–35 out of every 100 patients in the ED undergo an ECG. A 2019 survey of 1000 US EDs found that 28% of patients underwent an ECG [21]. The survey also reported that ECG use has increased by 1% per year over the last 3 years, reflecting an increase in patient complexity [21]. In our series, an ECG was performed on 32.2% of participants, representing the second predictive variable associated with TL3, with an odds ratio of 2.76.
Blood tests in the ED are important for diagnosis and treatment. They are used in triage before medical examination as part of clinical guidelines [22]. The usefulness of blood tests in the ED depends on patient age, severity and length of stay [20,23], but this can lead to an excessive number of tests [24]. In our data, blood tests were taken in 56.8% of cases, with a higher frequency (60.2%) in the TL3 group, in line with the Osman study [22] in which 62% of adult patients classified as less severe underwent blood sampling for laboratory tests.
Early warning scores are useful in identifying clinical deterioration in high-risk patients [25] and can facilitate decision-making when assigning severity codes and allocating resources [26]. Indeed, studies have shown that early warning scores provide additional information for assessing the risk of hospitalisation and mortality compared to traditional triage scales based on patient characteristics, even in non-critical cases [25]. As our study focused on non-critical cases, the NHS Early Warning Score (NEWS) was categorised as mild in 96.0% of cases and moderate in only 2.9%. The NEWS was higher in all categories of the HLC group, despite the low grade. Notwithstanding the limited number of non-critical cases with an NEWS >6, this was one of the most significant variables selected by the statistical model in predicting TL3 characteristics.
The decision whether or not to place a patient on a stretcher is important because it is one of the six main variables selected by the logistic model for identifying TL3. This helps to prioritise bed and staff assignments, optimising patient flow and reducing overcrowding delays. This lends weight to the use of stretcher occupancy as a key metric in resource allocation models and ED operational planning [27]. In our series, 17.7% of non-critical patients (59,311 cases) were assigned to stretcher allocation. This percentage was higher in the TL3 group (26.5%) than in the TL4–5 group (10.9%). Whether or not to place a patient on a stretcher is an important decision because it is one of the six main variables selected by the logistic model for predicting TL3.
Male patients visiting the ED, particularly those in older age categories, have more comorbidities [28] than females and are at greater risk of being admitted to intensive care and of dying. Our study confirms an association between male gender and an HLC on arrival at the ED, albeit with borderline statistical significance. Even in the presence of a statistical result, the clinical significance of the increased risk in males does not appear to be clinically relevant.

4.2. Limitations

Several limitations needed to be acknowledged.
First, the study identifies characteristics of non-critical cases, thereby expanding upon the original criteria, which only considered the number of needed resources. The statistical model, which was obtained using real-world data, successfully identifies the relevant variables. However, although this was a multicentre study, it should be noted that these results may not be generalisable due to their dependence on local contexts, even though individual hospitals were not included in the logistic model.
Second, the CEDIS-compliant list was used to classify the main complaints and case-mix. However, the reliability of this classification is questionable, as no analysis of intra- and inter-operator variability has been performed.
Third, the low frequency of procedures associated with cases with minor triage codes due to local organisational characteristics may have led the statistical model to prioritise some typologies to the detriment of other, less represented ones. It should also be considered that the differing representativeness of the variables could produce a statistically significant result with a negligible clinical significance. Examples include cases in the LLC group, obstetric and gynaecological disorders, and environmental disorders.
Fourth, the model showed an accuracy of 0.801 (0.011), with an optimal cutoff point of 0.517. This level of discriminatory power is considered acceptable for clinical purposes [29]. Unfortunately, the model was constructed with the available variables, but these do not take into account the judgement that may have prevailed over traditional variables. These models could be improved by refining the choice of variables, using appropriate outcome measures, analysing the results and eliminating the “self-fulfilling prophecy” effect [29]. Additional variables, such as severity scores, could improve the model’s performance [30].
Fifth, we did not consider subjects who underwent lab tests at triage vs. after the medical exam. This may have increased the number of urgent lab tests, overestimating the effect in the logistic model. We believe early lab test results did not influence the triage level code.
Sixth, there may be a correlation between the PP and their CDW variables in completing the treatment of patients. We do not propose a new classification tool, as this would require internal and external validation before it could be implemented.
Seventh, we considered the EDLoS as one of the variables to be tested in the model, using the actual time interval from arrival to discharge rather than an estimate made by triage nurses at the time of triage. The value obtained a posteriori constitutes a methodological limitation in the interpretation of the results, which must be taken into consideration.

4.3. Interpretation

Real-world data from a large study population indicate that certain characteristics of the presentation profile and clinical diagnostic workload are associated with high or low complexity among ED attendees. A stratification criterion based on the PP and CDW could improve the original model, which is based on estimating the number of resources needed to complete the clinical diagnostic pathway. These results pave the way for an in-depth discussion on the level assignment policy currently in use. If confirmed by further studies, following a procedure of both internal and external validation, our results could redefine the criteria for classifying non-critical cases at ED triage. To achieve this goal, additional information not considered by current models may be attained, such as multidimensional assessments in elderly subjects [30], or information on the expected level of care required.

4.4. Generalizability

Although the sample analysed was large, the study was conducted in an area with a homogeneous organisational model. Therefore, we cannot rule out the possibility that the results may not be fully replicable in areas with different organisational models.

Supplementary Materials

The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/jcm15031280/s1, Table S1: List of laboratory tests and interventions included in the CDW considered for the analyses in patients attending the ED with TL3 and TL4–5; Table S2: Number of resources needed in TL3 and TL4–5 groups; Figure S1: The distribution of decades in relation to gender in the TL3 and TL4–5 groups.

Author Contributions

A.F.: Conceptualization, funding acquisition, investigation, methodology, project administration, supervision, validation, visualisation, writing—original draft, writing—review and editing. L.P.: Formal analysis, methodology, software, and visualisation. F.B.: Formal analysis, methodology, software, visualisation, writing—original draft, and writing—review and editing. F.B.: Formal analysis, methodology, software, visualisation, writing—original draft, and writing—review and editing. B.B.: Validation, original draft, and writing—review and editing. D.M.: Data curation, formal analysis, funding acquisition, investigation, supervision, writing—original draft, and writing—review and editing. All authors contributed substantially to its revision and agreed to be accountable for all aspects of the work. A.F. takes responsibility for the paper as a whole. All authors have read and agreed to the published version of the manuscript.

Funding

The study was supported by Regione Emilia Romagna, FIN-RER project 2020: AVIN code 22 MIPE. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Institutional Review Board Statement

The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the ethical committee of CEROM—Comitato Etico della Romagna, Italy (9437/2019/I.5/268, 5 November 2021).

Informed Consent Statement

Patient consent was waived by the Ethics Committee, in accordance with a relevant Italian regulation (Article 110 of the Privacy Code) relating to this type of study.

Data Availability Statement

The data presented in this study are available on request from the corresponding author.

Acknowledgments

We are grateful to AUSL Romagna for the helpful support.

Conflicts of Interest

The authors declare no conflicts of interest.

Abbreviations

The following abbreviations are used in this manuscript:
CCICharlson Comorbidity Index
CDWClinical diagnostic workload
CHFCongestive Heart Failure
CKDHemiplegia, Chronic Kidney Disease
COPDChronic Obstructive Pulmonary Disease
CVAAcute Cerebrovascular Accidents or Transient Ischemic Attacks
DDementia
DMDiabetes Mellitus
EDEmergency Department
GTDConnective Tissue diseases,
HLCHigh Complexity Level
LLymphoma and Leukaemia
LDLiver Disease
LLCLow Level of Complexity
MIHistory of Myocardial Infarction
NEWSNational Early Warning Score
NRSNumeric rating scale
PPPresenting Profile
PUDPeptic Ulcer Disease
PVDPeripheral Vascular Disease
ROCReceiver Operating Characteristic
STSolid Tumours
TLTriage level

References

  1. Mirhaghi, A.; Heydari, A.; Mazlom, R.; Ebrahimi, M. The Reliability of the Canadian Triage and Acuity Scale: Meta-analysis. N. Am. J. Med. Sci. 2015, 7, 299–305. [Google Scholar] [CrossRef]
  2. Nicolaus, S.; Crelier, B.; Donzé, J.D.; Aubert, C.E. Definition of patient complexity in adults: A narrative review. J. Multimorb. Comorbidity 2022, 12, 26335565221081288. [Google Scholar] [CrossRef]
  3. Ng, C.-J.; Hsu, K.-H.; Kuan, J.-T.; Chiu, T.-F.; Chen, W.-K.; Lin, H.-J.; Bullard, M.J.; Chen, J.-C. Comparison between Canadian Triage and Acuity Scale and Taiwan Triage System in emergency departments. J. Formos. Med. Assoc. 2010, 109, 828–837. [Google Scholar] [CrossRef] [PubMed]
  4. Shlenger, D.; Cohen, A.; Hochman, G.; Pachys, G.; Trotzky, D. The effect of centrality bias on triage nurses in the emergency department. Sage Open Med. 2025, 13, 20503121251364742. [Google Scholar] [CrossRef]
  5. Giannouchos, T.V.; Ukert, B.; Wright, B. Concordance in Medical Urgency Classification of Discharge Diagnoses and Reasons for Visit. JAMA Netw. Open 2024, 7, e2350522. [Google Scholar] [CrossRef] [PubMed]
  6. Yancey, C.C.; O’Rourke, M.C. Emergency Department Triage. In StatPearls; StatPearls Publishing: Treasure Island, FL, USA, 2025. [Google Scholar]
  7. Ganjali, R.; Golmakani, R.; Ebrahimi, M.; Eslami, S.; Bolvardi, E. Accuracy of the Emergency Department Triage System using the Emergency Severity Index for Predicting Patient Outcome; A Single Center Experience. Bull. Emerg. Trauma 2020, 8, 115–120. [Google Scholar] [CrossRef]
  8. Davis, J.W.; Dirks, R.C.; Sue, L.P.; Kaups, K.L. Attempting to validate the overtriage/undertriage matrix at a Level I trauma center. J. Trauma Acute Care Surg. 2017, 83, 1173–1178. [Google Scholar] [CrossRef] [PubMed]
  9. Almutary, A.; Althunayyan, S.; Alenazi, K.; Alqahtani, A.; Alotaibi, B.; Ahmed, M.; Osman, I.S.; Kakpuri, A.; Alanazi, A.; Arafat, M.; et al. National Early Warning Score (NEWS) as Prognostic Triage Tool for Septic Patients. Infect. Drug Resist. 2020, 13, 3843–3851. [Google Scholar] [CrossRef]
  10. Boonstra, A.M.; Stewart, R.E.; Köke, A.J.A.; Oosterwijk, R.F.A.; Swaan, J.L.; Schreurs, K.M.G.; Schiphorst Preuper, H.R. Cut-Off Points for Mild, Moderate, and Severe Pain on the Numeric Rating Scale for Pain in Patients with Chronic Musculoskeletal Pain: Variability and Influence of Sex and Catastrophizing. Front. Psychol. 2016, 7, 1466. [Google Scholar] [CrossRef]
  11. Capponi, R.; Loguercio, V.; Guerrini, S.; Beltrami, G.; Vesprini, A.; Giostra, F. Does the numeric rating scale (NRS) represent the optimal tool for evaluating pain in the triage process of patients presenting to the ED? Results of a multicenter study. Acta Bio Med. Atenei Parm. 2016, 87, 347–352. [Google Scholar]
  12. Grafstein, E.; Unger, B.; Bullard, M.; Innes, G.; The Canadian Emergency Department Information System (CEDIS) Working Group. Canadian Emergency Department Information System (CEDIS) Presenting Complaint List (Version 1.0). Can. J. Emerg. Med. 2003, 5, 27–34. [Google Scholar] [CrossRef]
  13. Fluss, R.; Faraggi, D.; Reiser, B. Estimation of the Youden Index and its Associated Cutoff Point. Biom. J. 2005, 47, 458–472. [Google Scholar] [CrossRef]
  14. Ali, H.; Salleh, M.N.M.; Hussain, K.; Ahmad, A.; Ullah, A.; Muhammad, A.; Naseem, R.; Khan, M. A review on data preprocessing methods for class imbalance problem. Int. J. Eng. Technol. 2019, 8, 390–397. [Google Scholar]
  15. Dufour, I.; Chouinard, M.-C.; Dubuc, N.; Beaudin, J.; Lafontaine, S.; Hudon, C. Factors associated with frequent use of emergency-department services in a geriatric population: A systematic review. BMC Geriatr. 2019, 19, 185. [Google Scholar] [CrossRef]
  16. Breivik, H.; Collett, B.; Ventafridda, V.; Cohen, R.; Gallacher, D. Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment. Eur. J. Pain 2006, 10, 287–333. [Google Scholar] [CrossRef]
  17. Hämäläinen, J.; Kvist, T.; Kankkunen, P. Acute Pain Assessment Inadequacy in the Emergency Department: Patients’ Perspective. J. Patient Exp. 2022, 9, 23743735211049677. [Google Scholar] [CrossRef] [PubMed]
  18. Hachimi-Idrissi, S.; Coffey, F.; Hautz, W.E.; Leach, R.; Sauter, T.C.; Sforzi, I.; Dobias, V. Approaching acute pain in emergency settings: European Society for Emergency Medicine (EUSEM) guidelines-part 1: Assessment. Intern. Emerg. Med. 2020, 15, 1125–1139. [Google Scholar] [CrossRef] [PubMed]
  19. Nożewski, J.; Bondarczuk, R.; Hołody, G.; Kitt, M.; Mućka, N.; Religioni, U. Barriers to Improving Pain Management in the Emergency Department: Lessons from a Lean-Driven Quality Improvement Initiative. J. Clin. Med. 2025, 14, 4566. [Google Scholar] [CrossRef]
  20. Kaushik, N.; Khangulov, V.S.; O’Hara, M.; Arnaout, R. Reduction in laboratory turnaround time decreases emergency room length of stay. Open Access Emerg. Med. 2018, 10, 37–45. [Google Scholar] [CrossRef]
  21. Augustine, J.J. Statistical Trends of Diagnostic Testing in the Emergency Department. ACEP Now. Available online: https://www.acepnow.com/article/statistical-trends-of-diagnostic-testing-in-the-emergency-department/ (accessed on 9 September 2025).
  22. Osman, A.D.; Howell, J.; Yeoh, M.; Wilson, D.; Plummer, V.; Braitberg, G. Benefits of emergency department routine blood test performance on patients whose allocated triage category is not time critical: A retrospective study. BMC Health Serv. Res. 2024, 24, 1252. [Google Scholar] [CrossRef]
  23. Gurazada, S.G.; Gao, S.C.; Burstein, F.; Buntine, P. Predicting Patient Length of Stay in Australian Emergency Departments Using Data Mining. Sensors 2022, 22, 4968. [Google Scholar] [CrossRef]
  24. Wang, S.-T.; Weng, S.-J.; Yeh, T.-Y.; Chen, C.-H.; Tsai, Y.-T. Optimizing Emergency Department Patient Flow Through Bed Allocation Strategies: A Discrete-Event Simulation Study. INQ. J. Health Care Organ. Provis. Financ. 2025, 62, 00469580251335799. [Google Scholar] [CrossRef] [PubMed]
  25. Schinkel, M.; Bergsma, L.; Veldhuis, L.I.; Ridderikhof, M.L.; Holleman, F. Comparing complaint-based triage scales and early warning scores for emergency department triage. Emerg. Med. J. 2022, 39, 691–696. [Google Scholar] [CrossRef]
  26. Semeraro, F.; Corona, G.; Scquizzato, T.; Gamberini, L.; Valentini, A.; Tartaglione, M.; Scapigliati, A.; Ristagno, G.; Martella, C.; Descovich, C.; et al. New Early Warning Score: EMS Off-Label Use in Out-of-Hospital Patients. J. Clin. Med. 2021, 10, 2617. [Google Scholar] [CrossRef]
  27. Chisholm, D.; Wang, D.; Rich, T.A.; Grabove, M.; Sherlock, K.; Lang, E. A Multimodal Evaluation of an Emergency Department Electronic Tracking Board Utility Designed to Optimize Stretcher Utilization. Cureus 2020, 12, e11810. [Google Scholar] [CrossRef]
  28. Fabbri, A.; Polyzogopoulou, E.; Dündar, D.Z.; Slagman, A.; Ergin, M.; Janssens, K.A.C.; Bjornsen, L.P.; Somodi, S.; Višnja, N.A.; Demir, H.A.; et al. Sex disparities in older patients attending the european emergency departments: An EGERS sub-analysis. Emerg. Care J. 2025, 21, 13937. [Google Scholar] [CrossRef]
  29. Nelson, R.E.; Nelson, S.D.; Khader, K.; Perencevich, E.L.; Schweizer, M.L.; Rubin, M.A.; Graves, N.; Harbarth, S.; Stevens, V.W.; Samore, M.H. The Magnitude of Time-Dependent Bias in the Estimation of Excess Length of Stay Attributable to Healthcare-Associated Infections. Infect. Control Hosp. Epidemiol. 2015, 36, 1089–1094. [Google Scholar] [CrossRef] [PubMed]
  30. Pilotto, A.; Sancarlo, D.; Panza, F.; Paris, F.; D’Onofrio, G.; Cascavilla, L.; Addante, F.; Seripa, D.; Solfrizzi, V.; Dallapiccola, B.; et al. The Multidimensional Prognostic Index (MPI), Based on a Comprehensive Geriatric Assessment, Predicts Short- and Long-Term Mortality in Hospitalized Older Patients with Dementia. J. Alzheimer’s Dis. 2009, 18, 191–199. [Google Scholar] [CrossRef] [PubMed]
Figure 1. The flow diagram of the study.
Figure 1. The flow diagram of the study.
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Figure 2. Main features of the PP and CDW, in order of relevance, selected by the logistic model associated with TL3 (upper panel) and TL4–5 (lower panel). Data are reported as number of cases (%), odds ratio (OR) with 95% confidence intervals (CI). Statistical significance set at p < 0.05.
Figure 2. Main features of the PP and CDW, in order of relevance, selected by the logistic model associated with TL3 (upper panel) and TL4–5 (lower panel). Data are reported as number of cases (%), odds ratio (OR) with 95% confidence intervals (CI). Statistical significance set at p < 0.05.
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Figure 3. ROC plots of the risk score obtained from the logistic model. Accuracy was 0.816, with sensitivity and specificity at the optimal cutoff point (score of 0.437).
Figure 3. ROC plots of the risk score obtained from the logistic model. Accuracy was 0.816, with sensitivity and specificity at the optimal cutoff point (score of 0.437).
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Table 1. Baseline characteristics of the two groups. Data presented as number (%), with odds ratios (OR) and 95% confidence intervals (CI). Statistical significance set at p < 0.05. Age reported as median with [interquartile range].
Table 1. Baseline characteristics of the two groups. Data presented as number (%), with odds ratios (OR) and 95% confidence intervals (CI). Statistical significance set at p < 0.05. Age reported as median with [interquartile range].
Total, No.TL3, No. (%)TL4–5, No. (%)OR (95% CI)p-Value
Patients335,507145,355 (43,3)190,152 (56.7)----
Sex (Male) 168,457 (50.2)71,352 (49.1)97,105 (51.1)1.08 (1.07–1.10)<0.001
Age (Years)59 (interquartile range [IQR], 25)69 (interquartile range [IQR], 32)54 (interquartile range [IQR], 34)--<0.05
18–3039,590 (11.8)10,866 (7.5)28,724 (15.1)2.20 (2.15–2.25) <0.001
31–4035,080 (10.5)10,593 (7.3)24,487 (12.9)1.88 (1.84–1.93) <0.001
41–5042,180 (12.6)14,012 (9.6)28,168 (14.8)1.63 (1.60–1.67) <0.001
51–6050,966 (15.2)18,743 (12.9)32,223 (16.9)1.38 (1.35–1.41) <0.001
61–7045,020 (13.4)19,811 (13.6)25,209 (13.3)0.97 (0.95–0.99) 0.002
70+122,671 (36.6)71,330 (49.1)51,341 (27.0)0.38 (0.38–0.39)<0.001
NEWS
0 to 4322,409 (96.1)136,608 (94)185,801 (97.7)2.73 (2.63–2.84) <0.001
5 to 69579 (2.9)6078 (4.2)3501 (1.8)0.43 (0.41–0.45) <0.001
>63519 (1.0)2669 (1.8)850 (0.4)0.24 (0.22–0.26) <0.001
NRS
0 to 3285,197 (85.0)120,474 (82.9)164,723 (86.6)1.34 (1.31–1.36) <0.001
4 to 745,273 (13.5)21,809 (15.0)23,464 (12.3)0.80 (0.78–0.81) <0.001
>75037 (1.5)3072 (2.1)1965 (1.0)0.48 (0.46–0.51) <0.001
Table 2. Chief complaint categories in subjects attending the ED. Data presented as number of cases (%) with odds ratio (OR) and 95% confidence intervals (95% CI). Statistical significance set at p < 0.05.
Table 2. Chief complaint categories in subjects attending the ED. Data presented as number of cases (%) with odds ratio (OR) and 95% confidence intervals (95% CI). Statistical significance set at p < 0.05.
TypeTotal
No. (%)
TL3
No. (%)
TL4–5
No. (%)
OR
(95% CI)
p-Value
Environmental (ENV)283 (0.1)168 (0.1)115 (0.1)2.88 (2.25–3.68)<0.001
Mental Health (MH0)7172 (2.1)3369 (2.3)3803 (2.0)2.03 (1.93–2.14)<0.001
Cardiovascular System (CVS)54,412 (16.2)38,772 (26.7)15,640 (8.2)1.94 (1.88–2.00)<0.001
Cerebral Nervous System (CNS)32,520 (9.7)17,905 (12.3)14,615 (7.7)1.64 (1.59–1.69)<0.001
Trauma (TRA)14,888 (4.4)6484 (4.5)8404 (4.4)1.56 (1.49–1.62)<0.001
Respiratory (RES)21,747 (6.5)13,839 (9.5)7908 (4.2)1.44 (1.39–1.50)<0.001
Substance Misuse (SUB)1366 (0.4)577 (0.4)789 (0.4)1.40 (1.25–1.57)<0.001
Genitourinary (GU0)24,477 (7.3)10,917 (7.5)13,560 (7.1)0.97 (0.94–1.01)0.171
Gastrointestinal (GI0)46,318 (13.8)22,866 (15.7)23,452 (12.3)0.91 (0.88–0.94)<0.001
General and Minor (GEN)27,684 (8.2)11,958 (8.2)15,726 (8.3)0.73 (0.70–0.75)<0.001
Obstetrics/Gynaecology (GYN)2688 (0.8)569 (0.4)2119 (1.1)0.70 (0.64–0.77)<0.001
Orthopaedic (ORT)69,901 (20.8)13,068 (9.0)56,833 (29.9)0.48 (0.46–0.49)<0.001
Ears, Mouth, Throat, Neck, Nose (ENT)11,792 (3.5)2391 (1.6)9401 (4.9)0.47 (0.45–0.50)<0.001
Ophthalmology (OPT)7939 (2.4)894 (0.6)7045 (3.7)0.44 (0.41–0.48)<0.001
Dermatology (DER)12,319 (3.7)1578 (1.1)10,741 (5.6)0.36 (0.34–0.38)<0.001
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MDPI and ACS Style

Fabbri, A.; Pistore, L.; Bertini, F.; Benazzi, B.; Montesi, D. High- and Low-Complexity Features of Non-Critical Adult Patients in the Emergency Department. J. Clin. Med. 2026, 15, 1280. https://doi.org/10.3390/jcm15031280

AMA Style

Fabbri A, Pistore L, Bertini F, Benazzi B, Montesi D. High- and Low-Complexity Features of Non-Critical Adult Patients in the Emergency Department. Journal of Clinical Medicine. 2026; 15(3):1280. https://doi.org/10.3390/jcm15031280

Chicago/Turabian Style

Fabbri, Andrea, Laura Pistore, Flavio Bertini, Barbara Benazzi, and Danilo Montesi. 2026. "High- and Low-Complexity Features of Non-Critical Adult Patients in the Emergency Department" Journal of Clinical Medicine 15, no. 3: 1280. https://doi.org/10.3390/jcm15031280

APA Style

Fabbri, A., Pistore, L., Bertini, F., Benazzi, B., & Montesi, D. (2026). High- and Low-Complexity Features of Non-Critical Adult Patients in the Emergency Department. Journal of Clinical Medicine, 15(3), 1280. https://doi.org/10.3390/jcm15031280

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