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Volume 15
Issue 11
10.3390/jcm15114257
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Systematic Review

Hyaluronic Acid vs. PRP, PRF, and Collagen in Regenerative Endodontics: A Systematic Review

by
Aneeqah Maryam Farah Ahmad
1,
Tawfiq Hijazi Alsadi
2,
Agustina Muñoz Rodríguez
3,
Kais Hijazi Muwaquet
4,* and
Susana Muwaquet Rodriguez
5,*
1
Department of Dentistry, Faculty of Medicine and Health Science, Catholic University of Valencia, 46001 Valenci, Spain
2
Department of Orthodontics, Faculty of Medicine and Health Science, Catholic University of Valencia, 46001 Valencia, Spain
3
Department of Preventive Dentistry and Epidemiology, Faculty of Medicine and Health Science, Catholic University of Valencia, 46001 Valencia, Spain
4
Department of Dentistry, Faculty of Medicine and Health Science, Catholic University of Valencia, 46001 Valencia, Spain
5
Department of Restorative Dentistry and Endodontics, Faculty of Medicine and Health Science, Catholic University of Valencia, C/Quevedo, 2, 46001 Valencia, Spain
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2026, 15(11), 4257; https://doi.org/10.3390/jcm15114257
Submission received: 29 April 2026 / Revised: 16 May 2026 / Accepted: 19 May 2026 / Published: 31 May 2026
(This article belongs to the Topic Advances in Dental Materials)
Versions Notes

Abstract

Background: Regenerative endodontic procedures (REPs) aim to restore pulp vitality and promote root development in immature necrotic permanent teeth. Scaffold materials provide a 3D framework to support cellular migration, proliferation, and differentiation and play a critical role in regenerative interventions. Commonly used scaffolds include PRP, PRF, and collagen; however, hyaluronic acid has also demonstrated promising treatment outcomes. Objective: To evaluate whether hyaluronic acid (HA) provides superior regenerative outcomes compared to PRP, PRF, and collagen scaffolds. Methods: A systematic electronic search was conducted across PubMed, Scopus, and EBSCOhost. A total of 952 articles were identified in the initial search, of which 19 articles were included in the final review. Due to heterogeneity, a narrative synthesis was performed. Results: PRF demonstrated the most consistent improvement in root development and dentinal wall thickening. Apical closure and periapical healing were achieved across all scaffold types. Evidence for HA was limited, with no clear superiority identified. Conclusions: Current evidence does not support the superiority of HA over established scaffolds. Further standardised clinical trials are required to make definitive comparisons on scaffold effectiveness.
Keywords: collagen; hyaluronic acid; immature necrotic permanent teeth; platelet-rich fibrin; platelet-rich plasma; regenerative endodontics collagen; hyaluronic acid; immature necrotic permanent teeth; platelet-rich fibrin; platelet-rich plasma; regenerative endodontics

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MDPI and ACS Style

Ahmad, A.M.F.; Hijazi Alsadi, T.; Rodríguez, A.M.; Hijazi Muwaquet, K.; Muwaquet Rodriguez, S. Hyaluronic Acid vs. PRP, PRF, and Collagen in Regenerative Endodontics: A Systematic Review. J. Clin. Med. 2026, 15, 4257. https://doi.org/10.3390/jcm15114257

AMA Style

Ahmad AMF, Hijazi Alsadi T, Rodríguez AM, Hijazi Muwaquet K, Muwaquet Rodriguez S. Hyaluronic Acid vs. PRP, PRF, and Collagen in Regenerative Endodontics: A Systematic Review. Journal of Clinical Medicine. 2026; 15(11):4257. https://doi.org/10.3390/jcm15114257

Chicago/Turabian Style

Ahmad, Aneeqah Maryam Farah, Tawfiq Hijazi Alsadi, Agustina Muñoz Rodríguez, Kais Hijazi Muwaquet, and Susana Muwaquet Rodriguez. 2026. "Hyaluronic Acid vs. PRP, PRF, and Collagen in Regenerative Endodontics: A Systematic Review" Journal of Clinical Medicine 15, no. 11: 4257. https://doi.org/10.3390/jcm15114257

APA Style

Ahmad, A. M. F., Hijazi Alsadi, T., Rodríguez, A. M., Hijazi Muwaquet, K., & Muwaquet Rodriguez, S. (2026). Hyaluronic Acid vs. PRP, PRF, and Collagen in Regenerative Endodontics: A Systematic Review. Journal of Clinical Medicine, 15(11), 4257. https://doi.org/10.3390/jcm15114257

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