Impact of Postoperative Weight-Bearing Protocols on Prognosis in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis
Abstract
1. Introduction
2. Methods
2.1. Search Strategy
2.2. Selection Criteria
2.3. Data Extraction
2.4. Assessment of Quality and Bias
2.5. Statistical Analysis
2.6. Certainty of Evidence
3. Results
3.1. Search Results
3.2. Clinical Characteristics
3.3. Results of Quality and Risk-of-Bias Assessment
3.4. Mortality
3.5. Complications
3.6. Reoperation and LOS
3.7. Additional Analyses
3.8. Results of Evidence Certainty Assessment
4. Discussion
5. Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Mattisson, L.; Bojan, A.; Enocson, A. Epidemiology, treatment and mortality of trochanteric and subtrochanteric hip fractures: Data from the Swedish fracture register. BMC Musculoskelet. Disord. 2018, 19, 369. [Google Scholar] [CrossRef] [PubMed]
- Bhandari, M.; Swiontkowski, M. Management of Acute Hip Fracture. N. Engl. J. Med. 2017, 377, 2053–2062. [Google Scholar] [CrossRef]
- Tian, C.; Shi, L.; Wang, J.; Zhou, J.; Rui, C.; Yin, Y.; Du, W.; Chang, S.; Rui, Y. Global, regional, and national burdens of hip fractures in elderly individuals from 1990 to 2021 and predictions up to 2050: A systematic analysis of the Global Burden of Disease Study 2021. Arch. Gerontol. Geriatr. 2025, 133, 105832. [Google Scholar] [CrossRef]
- Sarode, A.L.; Su, E.; Drost, J.; Evan, M.; Haselton, L.; Blecker, N. The economic burden of hip fractures in the geriatric population by mental health illness and substance Use Status: National estimates 2016 to 2020. Injury 2025, 56, 112615. [Google Scholar] [CrossRef]
- Willers, C.; Norton, N.; Harvey, N.C.; Jacobson, T.; Johansson, H.; Lorentzon, M.; McCloskey, E.V.; Borgström, F.; Kanis, J.A. Osteoporosis in Europe: A compendium of country-specific reports. Arch. Osteoporos. 2022, 17, 23. [Google Scholar] [CrossRef]
- Chan, L.L.; Ho, Y.Y.; Taylor, M.E.; McVeigh, C.; Jung, S.; Armstrong, E.; Close, J.C.; Harvey, L.A. Incidence of fragility hip fracture across the Asia-pacific region: A systematic review. Arch. Gerontol. Geriatr. 2024, 123, 105422. [Google Scholar] [CrossRef]
- Roche, J.J.; Wenn, R.T.; Sahota, O.; Moran, C.G. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: Prospective observational cohort study. BMJ 2005, 331, 1374. [Google Scholar] [CrossRef] [PubMed]
- Andaloro, S.; Cacciatore, S.; Risoli, A.; Comodo, R.M.; Brancaccio, V.; Calvani, R.; Giusti, S.; Schlögl, M.; D’Angelo, E.; Tosato, M.; et al. Hip Fracture as a Systemic Disease in Older Adults: A Narrative Review on Multisystem Implications and Management. Med. Sci. 2025, 13, 89. [Google Scholar] [CrossRef] [PubMed]
- Leal, J.; Gray, A.M.; Prieto-Alhambra, D.; Arden, N.K.; Cooper, C.; Javaid, M.K.; Judge, A. Impact of hip fracture on hospital care costs: A population-based study. Osteoporos. Int. 2016, 27, 549–558. [Google Scholar] [CrossRef]
- Li, S.; Sun, T.; Liu, Z. Excess mortality of 1 year in elderly hip fracture patients compared with the general population in Beijing, China. Arch. Osteoporos. 2016, 11, 35. [Google Scholar] [CrossRef]
- Zhang, C.; Feng, J.; Wang, S.; Gao, P.; Xu, L.; Zhu, J.; Jia, J.; Liu, L.; Liu, G.; Wang, J.; et al. Incidence of and trends in hip fracture among adults in urban China: A nationwide retrospective cohort study. PLoS Med. 2020, 17, e1003180. [Google Scholar] [CrossRef]
- Moja, L.; Piatti, A.; Pecoraro, V.; Ricci, C.; Virgili, G.; Salanti, G.; Germagnoli, L.; Liberati, A.; Banfi, G. Timing matters in hip fracture surgery: Patients operated within 48 hours have better outcomes. A meta-analysis and meta-regression of over 190,000 patients. PLoS ONE 2012, 7, e46175. [Google Scholar] [CrossRef]
- Pfeufer, D.; Zeller, A.; Mehaffey, S.; Böcker, W.; Kammerlander, C.; Neuerburg, C. Weight-bearing restrictions reduce postoperative mobility in elderly hip fracture patients. Arch. Orthop. Trauma Surg. 2019, 139, 1253–1259. [Google Scholar] [CrossRef] [PubMed]
- Li, N.; Cheng, K.Y.; Zhang, J.; Liu, G.; Zhou, L.; Zhu, S.W.; Yang, M.H.; Wu, X.B.; Jiang, X.Y. Immediate weight bearing as tolerated versus delayed weight bearing following intramedullary fixation for geriatric intertrochanteric fractures: A post hoc analysis. BMC Musculoskelet. Disord. 2024, 25, 1041. [Google Scholar] [CrossRef] [PubMed]
- Jia, X.; Qiang, M.; Zhang, K.; Han, Q.; Wu, Y.; Chen, Y. Influence of Timing of Postoperative Weight-Bearing on Implant Failure Rate Among Older Patients with Intertrochanteric Hip Fractures: A Propensity Score Matching Cohort Study. Front. Med. 2021, 8, 795595. [Google Scholar] [CrossRef] [PubMed]
- Patel, N.; Chaudhari, M. Weight-Bearing Approaches After Neck of Femur Fractures: A Narrative Review of Evidence and Outcomes. Cureus 2025, 17, e84932. [Google Scholar] [CrossRef]
- Turabi, R.; Frihagen, F.; McGlasson, R.; Wyatt, D.; Trompeter, A.; Beaupre, L.; Cocco, L.F.; Costa, M.; Dinamarca-Montecinos, J.L.; Viveros-García, J.C.; et al. Fragility Fracture Network Position on Unrestricted Weight-Bearing After Hip Fracture Surgery. Geriatr. Orthop. Surg. Rehabil. 2025, 16, 21514593251351136. [Google Scholar] [CrossRef]
- Turabi, R.Y.; Wyatt, D.; Guerra, S.; O’Connell, M.D.L.; Khatun, T.; Sageer, S.A.; Alhazmi, A.; Sheehan, K.J. Barriers and facilitators of weight bearing after hip fracture surgery among older adults. A scoping review. Osteoporos. Int. 2023, 34, 1193–1205. [Google Scholar] [CrossRef]
- Gupta, R.K.; Gupta, V.; Gupta, N. Outcomes of osteoporotic trochanteric fractures treated with cement-augmented dynamic hip screw. Indian J. Orthop. 2012, 46, 640–645. [Google Scholar] [CrossRef]
- Angelini, A.; Trovarelli, G.; Berizzi, A.; Pala, E.; Breda, A.; Maraldi, M.; Ruggieri, P. Treatment of pathologic fractures of the proximal femur. Injury 2018, 49, S77–S83. [Google Scholar] [CrossRef]
- Tarrant, S.M.; Attia, J.; Balogh, Z.J. The influence of weight-bearing status on post-operative mobility and outcomes in geriatric hip fracture. Eur. J. Trauma Emerg. Surg. 2022, 48, 4093–4103. [Google Scholar] [CrossRef] [PubMed]
- Page, M.J.; McKenzie, J.E.; Bossuyt, P.M.; Boutron, I.; Hoffmann, T.C.; Mulrow, C.D.; Shamseer, L.; Tetzlaff, J.M.; Akl, E.A.; Brennan, S.E.; et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ 2021, 372, n71. [Google Scholar] [CrossRef]
- Morrison, A.; Polisena, J.; Husereau, D.; Moulton, K.; Clark, M.; Fiander, M.; Mierzwinski-Urban, M.; Clifford, T.; Hutton, B.; Rabb, D. The effect of English-language restriction on systematic review-based meta-analyses: A systematic review of empirical studies. Int. J. Technol. Assess. Health Care 2012, 28, 138–144. [Google Scholar] [CrossRef] [PubMed]
- Peters, M.D. Managing and Coding References for Systematic Reviews and Scoping Reviews in EndNote. Med. Ref. Serv. Q. 2017, 36, 19–31. [Google Scholar] [CrossRef] [PubMed]
- Stang, A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur. J. Epidemiol. 2010, 25, 603–605. [Google Scholar] [CrossRef]
- Sterne, J.A.C.; Savović, J.; Page, M.J.; Elbers, R.G.; Blencowe, N.S.; Boutron, I.; Cates, C.J.; Cheng, H.Y.; Corbett, M.S.; Eldridge, S.M.; et al. RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ 2019, 366, l4898. [Google Scholar] [CrossRef]
- Guyatt, G.H.; Oxman, A.D.; Vist, G.E.; Kunz, R.; Falck-Ytter, Y.; Alonso-Coello, P.; Schünemann, H.J. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008, 336, 924–926. [Google Scholar] [CrossRef]
- Topak, D., Jr.; Özdemir, M.A.; Telek, M.; Kaya, S.; Yönder, İ.H.; Bilal, B.; Doğar, F.; Bilal, O. A Prospective Randomized Trial: Does Full Weight Bearing Improve Functional Outcomes in Elderly Patients with Proximal Intramedullary Nailing After an Intertrochanteric Femur Fracture? Cureus 2023, 15, e48997. [Google Scholar] [CrossRef]
- Kuru, T.; Olçar, H.A. Effects of early mobilization and weight bearing on postoperative walking ability and pain in geriatric patients operated due to hip fracture: A retrospective analysis. Turk. J. Med. Sci. 2020, 50, 117–125. [Google Scholar]
- Baer, M.; Neuhaus, V.; Pape, H.C.; Ciritsis, B. Influence of mobilization and weight bearing on in-hospital outcome in geriatric patients with hip fractures. SICOT J. 2019, 5, 4. [Google Scholar] [CrossRef]
- Atzmon, R.; Drexler, M.; Ohana, N.; Nyska, M.; Palmanovich, E.; Dubin, J. The effect of postoperative weight-bearing status on mortality rate following proximal femoral fractures surgery. Arch. Orthop. Trauma Surg. 2022, 142, 947–953. [Google Scholar] [CrossRef]
- Ariza-Vega, P.; Kristensen, M.T.; Martín-Martín, L.; Jiménez-Moleón, J.J. Predictors of long-term mortality in older people with hip fracture. Arch. Phys. Med. Rehabil. 2015, 96, 1215–1221. [Google Scholar] [CrossRef]
- SanJosé-Pardo, I.; Valle-Cruz, J.A.; Donadeu-Sánchez, S.; Aguado, H.J.; País-Ortega, S.; Montoya-Adarraga, J.; Díez-Rodríguez, Á.; Alonso Del Olmo, J.A.; Mingo-Robinet, J. Is immediate weight bearing safe for subtrochanteric femur fractures in elderly patients treated by cephalomedullary nailing? A multicentric study in one hundred eighty-two patients. Eur. J. Orthop. Surg. Traumatol. 2024, 34, 2595–2603. [Google Scholar] [CrossRef]
- Ariza-Vega, P.; Jiménez-Moleón, J.J.; Kristensen, M.T. Non-weight-bearing status compromises the functional level up to 1 yr after hip fracture surgery. Am. J. Phys. Med. Rehabil. 2014, 93, 641–648. [Google Scholar] [CrossRef]
- Roberts, K.C.; Brox, W.T.; Jevsevar, D.S.; Sevarino, K. Management of hip fractures in the elderly. J. Am. Acad. Orthop. Surg. 2015, 23, 131–137. [Google Scholar] [CrossRef]





| Study | Publication Date, y | Country | Study Design | No. of Patients | Age, Mean (SD), y | Sex, %, Female | Fracture Type (n) | Surgical Procedure (n) | Protocol of Weight-Bearing |
|---|---|---|---|---|---|---|---|---|---|
| Topak et al. [28] | 2023 | Turkey | RCT | 85 | 76.67 (8.62) | 49.40% | Intertrochanteric femur fractures (85) | Proximal intramedullary nailing (85) | Full weight-bearing; Partial weight-bearing |
| KURU et al. [29] | 2020 | Turkey | Retrospective cohort study | 52 | 82.9 (6.5) | 69.20% | Intertrochanteric fractures (38); Femoral neck fractures (14) | Partial prosthesis (52) | Full weight-bearing; Partial weight-bearing |
| Balogh et al. [21] | 2022 | Australia | Retrospective cohort study | 1479 | Full weight-bearing: 83.8 (7.9); Restricted/non-weight-bearing: 81.3 (9.4) | Full weight-bearing: 70%; Restricted/non-weight-bearing: 59% | Intracapsular undisplaced/impacted (367); Intracapsular displaced (311); Peritrochanteric (incl. basicervical) (736); Subtrochanteric (65) | Cannulated screws (129); Cemented hemiarthroplasty (427); Uncemented hemiarthroplasty (28); Long femoral IM nail (246); Short femoral IM nail (504); Sliding hip screw (55); Cemented total hip replacement (78); Uncemented total hip replacement (3); Other (9) | Weight-bearing as tolerated; Restricted/non-weight-bearing |
| Yang et al. [14] | 2024 | China | Retrospective cohort study | 410 | Immediate weight-bearing as tolerated: 80.97 (7.56); Delayed weight-bearing: 80.91 (7.28) | Immediate weight-bearing as tolerated: 68.9%; Delayed weight-bearing: 73.6% | Intertrochanteric fractures (410) | Intramedullary fixation (410) | Weight-bearing as tolerated; Non-weight-bearing |
| Chen et al. [15] | 2021 | China | Retrospective cohort study | 806 | 77.8 (7.6) | 74.80% | Intertrochanteric fractures (806) | Intramedullary fixation (806) | Weight-bearing as tolerated; Non-weight-bearing |
| Neuhaus et al. [30] | 2019 | Switzerland | Retrospective cohort study | 219 | 83 (7.1) | 68% | Femoral neck (62); Trochanteric fractures (157) | Intramedullary nail (158); Total hip replacement (35); Hemiarthroplasty (26) | Full weight-bearing; Partial weight-bearing |
| Dubin et al. [31] | 2021 | Israel | Retrospective cohort study | 2104 | Full weight-bearing : 78.82 (12.5); Partial weight-bearing : 79.48 (9.6); Non-weight-bearing: 83.07 (8.14) | Full weight-bearing: 75.3%; Partial weight-bearing: 70.1%; Non-weight-bearing: 66.8% | Subcapital fractures (787)#; Pertrochanteric fractures (882) #; Basicervical fractures (146) #; Midcervical fractures (22) #; Subtrochanteric fractures (87) #; | Conservative (7) #; Cannulated screws (234) #; Proximal femoral nail (413) #; Thompson hemiarthroplasty (475) #; Richard’s nail (534) #; Dynamic hip screw (117) #; Trochanteric antegrade nail (128) #; Bipolar hemiarthroplasty (68) #; Percutaneous compression plate (16) # | Full weight-bearing; Partial weight-bearing Non-weight-bearing |
| Jiménez-Moleón et al. [32] | 2015 | Spain | Prospective cohort study | 275 | 81.4 (6.8) | 79% | Intracapsular fractures (cervical) (129) *; Extracapsular (inter- or subtrochanteric) fractures (143) * | Dynamic hip screw with plate (133) *; Intramedullary hip screw (46) *; Hemiarthroplasty (93) * | Weight-bearing as tolerated; Non-weight-bearing |
| SanJosé-Pardo et al. [33] | 2024 | Spain | Prospective cohort study | 182 | 85.53 | 84% | Subtrochanteric fractures (182) | Cephalomedullary nailing (182) | Weight-bearing as tolerated; Restricted/non-weight-bearing |
| Ariza-Vega et al. [34] | 2014 | Spain | Prospective cohort study | 194 | 81.4 (6.1) | 81% | Cervical (femoral neck) fractures (91); Trochanteric fractures (103) | Dynamic hip screw with plate (96); Intramedullary hip screw (33); Hemiarthroplasty (65) | Full weight-bearing; Non-weight-bearing |
| Newcastle-Ottawa | Selection | Comparability | Outcome | Total Score (9/9) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Study | Representativeness of Exposed Cohort | Selection of Nonexposed Cohort | Ascertainment of Exposure | Outcome of Interest Not Present at Start of Study | Assessment of Outcome | Sufficient Follow-Up Time | Adequacy of Follow-Up | ||
| KURU et al. [29] | * | * | * | * | * | * | - | * | 7/9 |
| Balogh et al. [21] | * | * | * | * | ** | * | * | * | 9/9 |
| Yang et al. [14] | * | * | * | * | ** | * | * | * | 9/9 |
| Chen et al. [15] | * | * | * | * | ** | * | * | * | 9/9 |
| Neuhaus et al. [30] | * | * | * | * | * | * | - | - | 6/9 |
| Dubin et al. [31] | * | * | * | * | * | * | * | - | 7/9 |
| Jiménez-Moleón et al. [32] | * | * | * | * | ** | * | * | * | 9/9 |
| SanJosé-Pardo et al. [33] | * | * | * | * | * | * | * | * | 8/9 |
| Ariza-Vega et al. [34] | * | * | * | * | * | * | * | - | 7/9 |
| Cochrane risk of bias tool | |||||||||
| Study | Randomization process | Deviations from intended interventions | Missing outcome data | Measurement of the outcome | Selection of the reported result | Overall Risk | |||
| Topak et al. [28] | Some concerns | Some concerns | High risk | Some concerns | Low risk | High risk | |||
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Xu, S.; Gao, F.; Chen, Y.; Liu, G.; Peng, K.; Zhang, J.; Chen, L.; Woo, Y.L.; Wong, R.M.Y.; Tian, M.; et al. Impact of Postoperative Weight-Bearing Protocols on Prognosis in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis. J. Clin. Med. 2026, 15, 3912. https://doi.org/10.3390/jcm15103912
Xu S, Gao F, Chen Y, Liu G, Peng K, Zhang J, Chen L, Woo YL, Wong RMY, Tian M, et al. Impact of Postoperative Weight-Bearing Protocols on Prognosis in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2026; 15(10):3912. https://doi.org/10.3390/jcm15103912
Chicago/Turabian StyleXu, Shanbin, Feng Gao, Yimin Chen, Gang Liu, Kangzu Peng, Jing Zhang, Liunan Chen, Yew Lok Woo, Ronald Man Yeung Wong, Maoyi Tian, and et al. 2026. "Impact of Postoperative Weight-Bearing Protocols on Prognosis in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 15, no. 10: 3912. https://doi.org/10.3390/jcm15103912
APA StyleXu, S., Gao, F., Chen, Y., Liu, G., Peng, K., Zhang, J., Chen, L., Woo, Y. L., Wong, R. M. Y., Tian, M., Wu, X., & Yang, M. (2026). Impact of Postoperative Weight-Bearing Protocols on Prognosis in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 15(10), 3912. https://doi.org/10.3390/jcm15103912

