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Open AccessSystematic Review
Evaluating Techniques for Vertical Ridge Augmentation via Comparative Study of Clinical Outcomes: A Systematic Review
by
Ioannis Frantzopoulos
Ioannis Frantzopoulos 1
,
Mihaela Băciuț
Mihaela Băciuț 2,
Oana Almășan
Oana Almășan 3,*
and
Avram Manea
Avram Manea 2
1
Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
2
Department of Maxillofacial Surgery and Implantology, Iuliu Hațieganu University of Medicine and Pharmacy, 400029 Cluj-Napoca, Romania
3
Department of Prosthetic Dentistry and Dental Materials, Iuliu Hațieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(24), 8639; https://doi.org/10.3390/jcm14248639 (registering DOI)
Submission received: 11 November 2025
/
Revised: 26 November 2025
/
Accepted: 2 December 2025
/
Published: 5 December 2025
Abstract
Background/Objectives: Vertical ridge augmentation (VRA) is often necessary in severe bone atrophy, yet the most predictable approach remains unclear. This systematic review compared Guided Bone Regeneration (GBR) and the Shell Technique (ST) for vertical bone gain (VBG), bone quality, complications, patient-reported outcomes (PROMs), and implant survival. Methods: Following PRISMA 2020 and PROSPERO registration (CRD420251128502), PubMed and Scopus databases were searched. Adults requiring VRA before implants were included. Interventions were GBR using titanium-reinforced dense PTFE (Polytetrafluoroethylene) or collagen membranes and ST using autogenous or allogeneic cortical plates. Results: Both techniques achieved clinically meaningful vertical augmentation. Median VBG was 4.24 mm for GBR (range 2.20–8.78 mm) and 5.16 mm for ST (range 3.10–7.60 mm) at re-entry (typically 4–9 months). Long-term series showed maintained gains for ST up to 10 years and multi-year stability after GBR in selected cohorts. Major early-healing complications were uncommon with both methods. Minor soft-tissue events varied; several GBR cohorts reported more exposures/dehiscence and occasional infections. Implant survival was uniformly high; validated PROMs were seldom reported. Conclusions: GBR and ST both enable vertical reconstruction sufficient for implant placement. ST tended toward higher median VBG but requires greater technical expertise and, when autogenous, adds donor-site morbidity; allogeneic shells reduce harvesting needs. GBR remains a versatile, donor-site-sparing alternative. Standardized outcome (including validated PROMs) reporting and head-to-head randomized trials are needed to refine case selection and confirm comparative effectiveness.
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MDPI and ACS Style
Frantzopoulos, I.; Băciuț, M.; Almășan, O.; Manea, A.
Evaluating Techniques for Vertical Ridge Augmentation via Comparative Study of Clinical Outcomes: A Systematic Review. J. Clin. Med. 2025, 14, 8639.
https://doi.org/10.3390/jcm14248639
AMA Style
Frantzopoulos I, Băciuț M, Almășan O, Manea A.
Evaluating Techniques for Vertical Ridge Augmentation via Comparative Study of Clinical Outcomes: A Systematic Review. Journal of Clinical Medicine. 2025; 14(24):8639.
https://doi.org/10.3390/jcm14248639
Chicago/Turabian Style
Frantzopoulos, Ioannis, Mihaela Băciuț, Oana Almășan, and Avram Manea.
2025. "Evaluating Techniques for Vertical Ridge Augmentation via Comparative Study of Clinical Outcomes: A Systematic Review" Journal of Clinical Medicine 14, no. 24: 8639.
https://doi.org/10.3390/jcm14248639
APA Style
Frantzopoulos, I., Băciuț, M., Almășan, O., & Manea, A.
(2025). Evaluating Techniques for Vertical Ridge Augmentation via Comparative Study of Clinical Outcomes: A Systematic Review. Journal of Clinical Medicine, 14(24), 8639.
https://doi.org/10.3390/jcm14248639
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