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Volume 14
Issue 23
10.3390/jcm14238464
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Anorganic Bovine Bone vs. Biphasic Calcium Phosphate in a Large Series of Maxillary Sinus Floor Elevations—A Non-randomized Clinico-Morphological Study

by
Antonio J. Flichy-Fernández
1,*,
Miguel Padial-Molina
2,3,*,
Natividad Martin-Morales
2,3,4,
Teresa Alegre-Domingo
1,
Miguel Peñarrocha-Diago
1,
Francisco O’Valle
3,4,5 and
Pablo Galindo-Moreno
2,3
1
Department of Oral Surgery and Implantology, Valencia University Medical and Dental School, 46010 Valencia, Spain
2
Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, 18071 Granada, Spain
3
Instituto de Investigación Biosanitaria ibs.GRANADA, 18012 Granada, Spain
4
Department of Pathology, School of Medicine, University of Granada, 18071 Granada, Spain
5
Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, 18071 Granada, Spain
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(23), 8464; https://doi.org/10.3390/jcm14238464 (registering DOI)
Submission received: 5 October 2025 / Revised: 14 November 2025 / Accepted: 27 November 2025 / Published: 28 November 2025
(This article belongs to the Special Issue Implant Dentistry: New Challenges and Complication Management)
Versions Notes

Abstract

Background: To compare the histological and histomorphometrical outcomes after sinus floor elevation using an anorganic bovine bone biomaterial or a biphasic calcium phosphate biomaterial. Material and methods: Patients who needed maxillary sinus elevation were included in this study. A total of 68 implant sites were evaluated from a total of 42 patients. Twenty patients were treated with anorganic bovine bone, while 22 were treated with biphasic calcium phosphate biomaterial. Morphological and morphometrical studies were performed on the bone samples collected during implant placement. Results: Both biomaterials induced similar relative areas of mineralized tissue overall, particularly if only the area of grafted bone was considered. In turn, a higher proportion of non-mineralized tissue was observed in cases of biphasic calcium phosphate biomaterial with less area of remnant biomaterial particles. None of the implants failed at one year of follow-up. Conclusions: Although both biomaterials induce a similar amount of bone formation, the histopathological characteristics of the grafts are different, with a greater proportion of scar connective tissue with the biphasic calcium phosphate biomaterial.
Keywords: sinus floor elevation; xenograft; alloplastic material; clinical study sinus floor elevation; xenograft; alloplastic material; clinical study

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MDPI and ACS Style

Flichy-Fernández, A.J.; Padial-Molina, M.; Martin-Morales, N.; Alegre-Domingo, T.; Peñarrocha-Diago, M.; O’Valle, F.; Galindo-Moreno, P. Anorganic Bovine Bone vs. Biphasic Calcium Phosphate in a Large Series of Maxillary Sinus Floor Elevations—A Non-randomized Clinico-Morphological Study. J. Clin. Med. 2025, 14, 8464. https://doi.org/10.3390/jcm14238464

AMA Style

Flichy-Fernández AJ, Padial-Molina M, Martin-Morales N, Alegre-Domingo T, Peñarrocha-Diago M, O’Valle F, Galindo-Moreno P. Anorganic Bovine Bone vs. Biphasic Calcium Phosphate in a Large Series of Maxillary Sinus Floor Elevations—A Non-randomized Clinico-Morphological Study. Journal of Clinical Medicine. 2025; 14(23):8464. https://doi.org/10.3390/jcm14238464

Chicago/Turabian Style

Flichy-Fernández, Antonio J., Miguel Padial-Molina, Natividad Martin-Morales, Teresa Alegre-Domingo, Miguel Peñarrocha-Diago, Francisco O’Valle, and Pablo Galindo-Moreno. 2025. "Anorganic Bovine Bone vs. Biphasic Calcium Phosphate in a Large Series of Maxillary Sinus Floor Elevations—A Non-randomized Clinico-Morphological Study" Journal of Clinical Medicine 14, no. 23: 8464. https://doi.org/10.3390/jcm14238464

APA Style

Flichy-Fernández, A. J., Padial-Molina, M., Martin-Morales, N., Alegre-Domingo, T., Peñarrocha-Diago, M., O’Valle, F., & Galindo-Moreno, P. (2025). Anorganic Bovine Bone vs. Biphasic Calcium Phosphate in a Large Series of Maxillary Sinus Floor Elevations—A Non-randomized Clinico-Morphological Study. Journal of Clinical Medicine, 14(23), 8464. https://doi.org/10.3390/jcm14238464

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