A Novel Protocol for Feasibility and Safety in Early Discharge with ACS

Acute coronary syndrome is the primary reason for admission to cardiology services and involves significant resource consumption. Currently, low-risk patients are recommended for discharge within the first 48–72 h, enabling early initiation of cardiac rehabilitation with proper follow-up. This is crucial not only as an efficiency marker but also because current evidence has shown it to be a safe and feasible strategy. Thus, this work aims to provide a comprehensive review of the current evidence on early discharge in acute coronary syndrome and propose a new, intuitive, objective, and easy-to-use tool: the LATE2ACS protocol. This is a narrative, hypothesis-generating review; LATE2ACS is presented as a preliminary, exploratory checklist rather than a definitive or implementable score. Its added value lies in operationalizing post-PCI early discharge decision-making across ACS as a pragmatic bedside checklist that complements, rather than replaces, prognostic scores such as TIMI, GRACE, Zwolle, and CADILLAC.