Efficacy of Noofen 250 mg Capsules for the Management of Anxious–Neurotic Symptoms in Patients with Adjustment Disorder
Abstract
1. Introduction
1.1. Background
1.2. Stress and Health
2. Materials and Methods
2.1. Study Objectives
2.2. Intervention
2.3. The Adjustment Disorder New Module 20-Item Questionnaire (ADNM-20)
2.4. Statistical Analysis
2.5. Adverse Events
3. Results
3.1. Characteristics of the Study Population
3.2. Change in Individual Items of ADNM-20
3.3. Consistency Between Patient and Clinician Reported Outcomes
3.4. ADNM-20 Questionnaire, User Experience
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
ADNM-20 | Adjustment Disorder New Module 20-item questionnaire |
AjD | Adjustment Disorder |
ATC | Anatomical Therapeutic Chemical Classification |
DSM-5 | Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition |
GABA | Gamma-aminobutyric acid |
ICD-10 | International Classification of Diseases, 10th Revision |
ICD-11 | International Classification of Diseases, 11th Revision |
n/a | Not applicable |
PRO | Patient-reported outcome |
QE84 | ICD-11 code for acute stress reaction |
QD85 | ICD-11 code for burnout syndrome |
SPSS | Statistical Package for the Social Sciences |
ClinRO | Clinician-reported outcome |
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Stressful Life Events * | Reporters, % |
---|---|
Too much/too little work | 63 |
Pressure to meet deadlines/time pressure | 47 |
Family conflicts | 46 |
Conflicts in working life | 30 |
Illness of a loved one | 30 |
Financial problems | 30 |
Death of a loved one | 19 |
Termination of an important leisure activity | 19 |
Own serious illness | 17 |
Moving to a new home | 13 |
Divorce/separation | 11 |
Unemployment | 11 |
Conflicts with neighbors | 6 |
Assault | 6 |
Serious accident | 4 |
Adjustment due to retirement | 1 |
Any other stressful event | 28 |
Summary Points | Baseline, Mean (SD) | After Treatment, Mean (SD) | Difference ^ |
---|---|---|---|
Total score | 60.3 (10.5) | 45.5 (12.3) | 14.8 (11.3) |
Core symptoms | 24.0 (4.9) | 17.4 (5.2) | 6.6 (4.9) |
Accessory symptoms | 36.3 (6.1) | 28.1 (7.4) | 8.2 (6.9) |
Subscales points | Baseline, mean (SD) | After treatment, mean (SD) | Difference ^ |
Preoccupations with stressor | 12.5 (2.7) | 9.2 (2.8) | 3.4 (2.7) |
Failure to adapt | 11.5 (2.9) | 8.3 (2.7) | 3.2 (2.7) |
Avoidance | 12.0 (2.5) | 9.8 (2.8) | 2.2 (2.8) |
Depressed mood | 8.8 (2.1) | 6.7 (2.0) | 2.1 (2.2) |
Anxiety | 5.8 (1.4) | 4.4 (1.4) | 1.4 (1.5) |
Impulse disturbance | 9.7 (2.0) | 7.1 (2.3) | 2.6 (2.2) |
Symptom severity * | Baseline | After treatment | p value |
Low | 12.2% | 7.8% | <0.19 |
Moderate | 31.1% | 55.6% | <0.001 |
High | 56.7% | 22.2% | <0.001 |
Under the lower cut-off value | n/a | 14.4% | - |
Clinician’s Assessment of Symptom Change from Baseline | Change in ADNM-20 Total Score; Points; Mean (SD); Min, Max Difference from Baseline; Significance |
---|---|
Improved significantly (n = 33), 36.7% | −8.8 (4.9) −3; −60, p < 0.001 |
Improved (n = 49), 55.4% | −21.3 (10.5), 1; −19, p < 0.001 |
Not improved (n = 8), 8.9% | 0.75 (3.1) −3; 6, p = 0.26 |
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Tērauds, E.; Dansone, G.; Troshina, Y. Efficacy of Noofen 250 mg Capsules for the Management of Anxious–Neurotic Symptoms in Patients with Adjustment Disorder. J. Clin. Med. 2025, 14, 5570. https://doi.org/10.3390/jcm14155570
Tērauds E, Dansone G, Troshina Y. Efficacy of Noofen 250 mg Capsules for the Management of Anxious–Neurotic Symptoms in Patients with Adjustment Disorder. Journal of Clinical Medicine. 2025; 14(15):5570. https://doi.org/10.3390/jcm14155570
Chicago/Turabian StyleTērauds, Elmārs, Guna Dansone, and Yulia Troshina. 2025. "Efficacy of Noofen 250 mg Capsules for the Management of Anxious–Neurotic Symptoms in Patients with Adjustment Disorder" Journal of Clinical Medicine 14, no. 15: 5570. https://doi.org/10.3390/jcm14155570
APA StyleTērauds, E., Dansone, G., & Troshina, Y. (2025). Efficacy of Noofen 250 mg Capsules for the Management of Anxious–Neurotic Symptoms in Patients with Adjustment Disorder. Journal of Clinical Medicine, 14(15), 5570. https://doi.org/10.3390/jcm14155570