High Sensitive Cardiac Troponin-I (Hs-cTnI) Levels in Asymptomatic Hemodialysis Patients †
Abstract
1. Introduction
2. Methods
2.1. Study Population
2.2. Clinical Data and Study Outcome
2.3. Patients Follow-Up
2.4. Statement of Ethics
2.5. Statistical Analysis
3. Results
3.1. Dialysis Characteristics
3.2. Hs-cTnI Levels
3.3. Hs-cTnI and “Gray Zone” Levels
3.4. Outcomes
4. Discussion
4.1. Baseline hs-TnI Level in Hemodialysis Patients
4.2. Hemodialysis Effect on the hs-TnI Levels
4.3. Clinical Associations
4.4. Diagnostic Challenges
4.5. Study Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total | |
---|---|
N = 56 | |
Age (SD), years | 71.8 (±12.9) |
Male (%) | 35 (62.5%) |
BMI (SD) | 27.7 (±5.27) |
HTN (%) | 51 (91.1%) |
DLP (%) | 47 (83.9%) |
DM (%) | 35 (62.5%) |
Smoker † (%) (n = 54) | 13 (23.2%) |
Prior CAD (%) | 25 (44.6%) |
Prior PCI (%) | 19 (33.9%) |
Prior CABG (%) | 7 (12.5%) |
Stroke (%) | 15 (26.8%) |
PAD (%) | 10 (17.9%) |
CHF (%) | 27 (48.2%) |
LVEF (%) (n = 54) | |
≥50% | 38 (70.4%) |
40–49% | 8 (14.8%) |
<40% | 8 (14.8%) |
PHT ¤ (%) (n = 55) | 26 (46.4%) |
AF/AFL (%) | 23 (41.1%) |
Anemia (%) | 53 (94.6%) |
Malignancy † (%) | 8 (14.3%) |
Total | |
---|---|
N = 56 | |
Cause of ESRD † (%) | |
DM | 22 (39.3%) |
HTN | 9 (16.1%) |
IgA nephropathy | 2 (3.6%) |
FSGS | 3 (5.4%) |
CRS | 4 (7.1%) |
Amyloidosis | 1 (1.8%) |
Vasculitis | 4 (7.1%) |
PKD | 2 (3.6%) |
GN | 2 (3.6%) |
Lithium | 2 (3.6%) |
MM | 1 (1.8%) |
Uknown | 4 (7.1%) |
Dialysis vintage (SD), months | 54.1 (±63.2) |
Dialysis session duration (SD), hours | 3.65 (±0.409) |
Type of solution (%) | |
Standard | 41 (73.2%) |
Low Ca | 10 (17.9%) |
High Ca | 1 (1.8%) |
Standard + KCl | 3 (5.4%) |
Low Ca + KCl | 1 (1.8%) |
Dry weight (SD), kg | 73.8 (±16.4) |
Intradialytic weight gain (SD), kg | 1.42 (±2.72) |
Target loss (SD), L | 2.63 (±0.980) |
MAP pre-dialysis (SD), mmHg | 91.1 (±16.0) |
MAP post-dialysis (SD), mmHg | 84.7 (±13.2) |
Delta MAP ¤ (SD), mmHg | 6.05 (±16.5) |
Kt/V (SD) | 1.38 (±0.253) |
Above Median (N = 28) | Below Median (N = 28) | p-Value | |
---|---|---|---|
Age (SD), years | 74.9 (±12.9) | 68.7 (±12.3) | 0.034 |
PHT (%) (n = 55) | 17 (60.7%) | 9 (32.1%) | 0.076 |
Creatinine pre-dialysis (SD), mg/dL | 6.52 (±1.56) | 7.87 (±2.27) | 0.019 |
Creatinine post-dialysis (SD), mg/dL | 2.30 (±0.771) | 2.88 (±0.936) | 0.011 |
Cause of ESRD † (%) | |||
DM | 11 (39.3%) | 11 (39.3%) | 0.013 |
HTN | 9 (32.1%) | 0 (0%) | |
IGA nephropathy | 1 (3.6%) | 1 (3.6%) | |
FSGS | 0 (0%) | 3 (10.7%) | |
CRS | 2 (7.1%) | 2 (7.1%) | |
Amyloidosis | 1 (3.6%) | 0 (0%) | |
Vasculitis | 0 (0%) | 4 (14.3%) | |
PKD | 0 (0%) | 2 (7.1%) | |
GN | 0 (0%) | 2 (7.1%) | |
Lithium | 2 (7.1%) | 0 (0%) | |
MM | 0 (0%) | 1 (3.6%) | |
Uknown | 2 (7.1%) | 2 (7.1%) | |
Intradialytic weight gain (SD), kg | 1.38 (±0.932) | 1.47 (±3.77) | 0.03 |
Target loss (SD), L | 2.43 (±0.920) | 2.83 (±1.01) | 0.047 |
Number of hospitalizations (SD) | 1.11 (±1.45) | 0.536 (±0.999) | 0.0746 |
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Rabi, O.; Shavit, L.; Loutati, R.; Taha, L.; Karmi, M.; Brin, A.; Deeb, D.; Levi, N.; Fink, N.; Sabouret, P.; et al. High Sensitive Cardiac Troponin-I (Hs-cTnI) Levels in Asymptomatic Hemodialysis Patients. J. Clin. Med. 2025, 14, 5470. https://doi.org/10.3390/jcm14155470
Rabi O, Shavit L, Loutati R, Taha L, Karmi M, Brin A, Deeb D, Levi N, Fink N, Sabouret P, et al. High Sensitive Cardiac Troponin-I (Hs-cTnI) Levels in Asymptomatic Hemodialysis Patients. Journal of Clinical Medicine. 2025; 14(15):5470. https://doi.org/10.3390/jcm14155470
Chicago/Turabian StyleRabi, Ofir, Linda Shavit, Ranel Loutati, Louay Taha, Mohammad Karmi, Akiva Brin, Dana Deeb, Nir Levi, Noam Fink, Pierre Sabouret, and et al. 2025. "High Sensitive Cardiac Troponin-I (Hs-cTnI) Levels in Asymptomatic Hemodialysis Patients" Journal of Clinical Medicine 14, no. 15: 5470. https://doi.org/10.3390/jcm14155470
APA StyleRabi, O., Shavit, L., Loutati, R., Taha, L., Karmi, M., Brin, A., Deeb, D., Levi, N., Fink, N., Sabouret, P., Manassra, M., Qadan, A., Amro, M., Glikson, M., & Asher, E. (2025). High Sensitive Cardiac Troponin-I (Hs-cTnI) Levels in Asymptomatic Hemodialysis Patients. Journal of Clinical Medicine, 14(15), 5470. https://doi.org/10.3390/jcm14155470