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Volume 14
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Systematic Review

The Usefulness of 2-[18F]FDG PET or PET/CT in Extranodal Natural Killer/T-Cell Lymphoma: A Systematic Review and Meta-Analysis

by
Domenico Albano
1,2,*,
Carlo Rodella
3,
Alessandra Tucci
4,
Giorgio Treglia
5,6,7,
Francesco Bertagna
1,2,
Arturo Chiti
8 and
Federico Fallanca
8
1
Nuclear Medicine, ASST Spedali Civili Brescia, 25123 Brescia, Italy
2
Nuclear Medicine, Università degli Studi di Brescia, 25125 Brescia, Italy
3
Health Physics Department, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
4
Department of Haematology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy
5
Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), 6900 Lugano, Switzerland
6
Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland
7
Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland
8
San Raffaele Scientific Institute, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(13), 4582; https://doi.org/10.3390/jcm14134582 (registering DOI)
Submission received: 15 May 2025 / Revised: 19 June 2025 / Accepted: 26 June 2025 / Published: 27 June 2025
(This article belongs to the Special Issue PET/CT Imaging in Oncology: Clinical Updates and Prospects)
Versions Notes

Abstract

Background/Objectives: Extranodal NK-/T-cell lymphoma (ENKTCL) is a rare and highly aggressive lymphoma with a bad prognosis. The aim of our analysis is to evaluate existing research on the potential usefulness of fluorine-18-fluorodeoxyglucose positron emission tomography or positron/computed tomography (2-[18F]FDG PET or PET/CT) in the management of patients with ENKTCL. Methods: A complete search of the literature was conducted across Scopus, PubMed/MEDLINE, and Embase databases, focusing on articles published up to March 2025. Results: A total of 21 studies that investigated the role of 2-[18F]FDG PET or PET/CT in ENKTCL were included in our analysis. The main findings from the literature analysis were (1) 2-[18F]FDG PET/CT seems to be helpful in staging settings, showing a better diagnostic performance than conventional imaging and a positive impact on clinical stage; (2) 2-[18F]FDG PET/CT had excellent negative predictive value for detecting bone marrow involvement, especially in early-stage disease; and (3) qualitative and semiquantitative PET parameters might predict prognosis. Conclusions: Despite several limitations affecting this analysis, especially related to the heterogeneity of the studies included, 2-[18F]FDG PET/CT seems to be a useful tool for the evaluation of ENKTCL.
Keywords: PET/CT; PET; nuclear medicine; ENKTCL; lymphoma; molecular imaging; positron emission tomography; hybrid imaging; lymphoproliferative disorders; extranodal lymphoma PET/CT; PET; nuclear medicine; ENKTCL; lymphoma; molecular imaging; positron emission tomography; hybrid imaging; lymphoproliferative disorders; extranodal lymphoma

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MDPI and ACS Style

Albano, D.; Rodella, C.; Tucci, A.; Treglia, G.; Bertagna, F.; Chiti, A.; Fallanca, F. The Usefulness of 2-[18F]FDG PET or PET/CT in Extranodal Natural Killer/T-Cell Lymphoma: A Systematic Review and Meta-Analysis. J. Clin. Med. 2025, 14, 4582. https://doi.org/10.3390/jcm14134582

AMA Style

Albano D, Rodella C, Tucci A, Treglia G, Bertagna F, Chiti A, Fallanca F. The Usefulness of 2-[18F]FDG PET or PET/CT in Extranodal Natural Killer/T-Cell Lymphoma: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2025; 14(13):4582. https://doi.org/10.3390/jcm14134582

Chicago/Turabian Style

Albano, Domenico, Carlo Rodella, Alessandra Tucci, Giorgio Treglia, Francesco Bertagna, Arturo Chiti, and Federico Fallanca. 2025. "The Usefulness of 2-[18F]FDG PET or PET/CT in Extranodal Natural Killer/T-Cell Lymphoma: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 14, no. 13: 4582. https://doi.org/10.3390/jcm14134582

APA Style

Albano, D., Rodella, C., Tucci, A., Treglia, G., Bertagna, F., Chiti, A., & Fallanca, F. (2025). The Usefulness of 2-[18F]FDG PET or PET/CT in Extranodal Natural Killer/T-Cell Lymphoma: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 14(13), 4582. https://doi.org/10.3390/jcm14134582

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