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Review

The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure

by
Anastasios Potiris
1,*,†,
Eleni Alyfanti
1,†,
Eirini Drakaki
2,
Despoina Mavrogianni
2,
Theodoros Karampitsakos
1,
Pavlos Machairoudias
1,
Spyridon Topis
1,
Athanasios Zikopoulos
3,
Chara Skentou
4,
Periklis Panagopoulos
1,
Peter Drakakis
1 and
Sofoklis Stavros
1
1
Third Department of Obstetrics and Gynecology, Medical School, University General Hospital “ATTIKON”, National and Kapodistrian University of Athens, 12462 Athens, Greece
2
First Department of Obstetrics and Gynecology, Medical School, Alexandra Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
3
Department of Obstetrics and Gynecology, Royal Cornwall Hospital, Treliske, Truro TR1 3LQ, UK
4
Department of Obstetrics and Gynecology, Medical School of the University of Ioannina, 45110 Ioannina, Greece
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2024, 13(7), 2145; https://doi.org/10.3390/jcm13072145
Submission received: 13 March 2024 / Revised: 1 April 2024 / Accepted: 5 April 2024 / Published: 8 April 2024
(This article belongs to the Special Issue Challenges in Diagnosis and Treatment of Infertility)
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Abstract

Recurrent implantation failure (RIF) poses a significant challenge in assisted reproductive technology (ART) outcomes. The endometrium plays a crucial role in embryo implantation, and its protein expression profile is integral in determining receptivity. Proteomics has emerged as a valuable tool in unraveling the molecular intricacies underlying endometrial receptivity and RIF. The aim of the present review is to analyze the contribution of proteomics to the understanding of endometrial protein expression in women with RIF, based on the results of significant proteomic studies. Medline/Pubmed databases were searched using keywords pertaining to proteomics combined with terms related to RIF. 15 studies were included in the present review. Several proteins have been found to exbibit differential expression in endometrial biopsies and fluid samples between fertile women and women with RIF during the receptive endometrial phase. The profile of endometrial proteins varied significantly among the studies. Nevertheless, similar changes in the expression levels of annexin-6, progesterone receptor, MMP-2, and MMP-9 in the endometrium of women with RIF, were found in more than one study indicating that certain proteins could potentially be effective biomarkers of endometrial receptivity. Proteomics contributes significantly to the understanding of protein expression in the endometrium of women with RIF and the analysis of proteins in endometrial fluid are promising for improving the clinical management of RIF.
Keywords: proteomics; recurrent implantation failure (RIF); endometrial protein expression; biomarkers; endometrial receptivity proteomics; recurrent implantation failure (RIF); endometrial protein expression; biomarkers; endometrial receptivity
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MDPI and ACS Style

Potiris, A.; Alyfanti, E.; Drakaki, E.; Mavrogianni, D.; Karampitsakos, T.; Machairoudias, P.; Topis, S.; Zikopoulos, A.; Skentou, C.; Panagopoulos, P.; et al. The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure. J. Clin. Med. 2024, 13, 2145. https://doi.org/10.3390/jcm13072145

AMA Style

Potiris A, Alyfanti E, Drakaki E, Mavrogianni D, Karampitsakos T, Machairoudias P, Topis S, Zikopoulos A, Skentou C, Panagopoulos P, et al. The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure. Journal of Clinical Medicine. 2024; 13(7):2145. https://doi.org/10.3390/jcm13072145

Chicago/Turabian Style

Potiris, Anastasios, Eleni Alyfanti, Eirini Drakaki, Despoina Mavrogianni, Theodoros Karampitsakos, Pavlos Machairoudias, Spyridon Topis, Athanasios Zikopoulos, Chara Skentou, Periklis Panagopoulos, and et al. 2024. "The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure" Journal of Clinical Medicine 13, no. 7: 2145. https://doi.org/10.3390/jcm13072145

APA Style

Potiris, A., Alyfanti, E., Drakaki, E., Mavrogianni, D., Karampitsakos, T., Machairoudias, P., Topis, S., Zikopoulos, A., Skentou, C., Panagopoulos, P., Drakakis, P., & Stavros, S. (2024). The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure. Journal of Clinical Medicine, 13(7), 2145. https://doi.org/10.3390/jcm13072145

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