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Volume 13
Issue 21
10.3390/jcm13216606
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Background:
Systematic Review

Prothrombotic Rebound After Discontinuation of Direct Oral Anticoagulants Therapy: A Systematic Review

by
Marta Frydrych
1,*,
Maciej Janeczek
2,*,
Agata Małyszek
2,
Kamil Nelke
3,4,
Maciej Dobrzyński
5 and
Marceli Lukaszewski
1
1
Anaesthesiology and Intensive Care Unit, Sokolowski Specialist Hospital in Walbrzych, Sokolowski 4, 58-309 Walbrzych, Poland
2
Department of Biostructure and Animal Physiology, Wroclaw University of Environmental and Life Sciences, Kożuchowska 1, 51-631 Wroclaw, Poland
3
Maxillo-Facial Surgery Ward, EMC Hospital, Pilczycka 144, 54-144 Wroclaw, Poland
4
Academy of Applied Sciences Angelus Silesius in Walbrzych, Health Department, Zamkowa 4, 58-300 Walbrzych, Poland
5
Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(21), 6606; https://doi.org/10.3390/jcm13216606
Submission received: 23 August 2024 / Revised: 23 September 2024 / Accepted: 1 November 2024 / Published: 3 November 2024
(This article belongs to the Special Issue Advances in Thrombotic Disorders and Antithrombotic Treatments)
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Abstract

Background/Objectives: The practice of holding anticoagulation is a relatively common approach, with the aim of either preventing excessive bleeding in preparation for surgical procedures or managing acute bleeding episodes. Methods: To assess the relationship between the discontinuation of direct oral anticoagulants (DOACs) therapy and the condition of hypercoagulability, a systematic review of the literature was conducted, following PRISMA guidelines, in PubMed/MEDLINE, Cochrane, and Google Scholar. These databases were searched for all publications that described a rebound phenomenon or hypercoagulability state after DOACs discontinuation. Results: A total of 1494 articles were selected from searched databases, and 29 were eligible. A final total of 16 case reports and 14 original research articles were subjected to analysis. Conclusions: The results of this study indicate that the cessation of DOAC therapy may be associated with an increased risk of thrombotic events. More studies are required to ascertain whether DOACs treatment cessation can be linked to rebound phenomena associated with thromboembolic events. This will provide the data needed to determine the incidence and risk of this phenomenon.
Keywords: DOACs; dabigatran; rivaroxaban; apixaban; edoxaban; prothrombotic rebound; hypercoagulability; antithrombotic therapy DOACs; dabigatran; rivaroxaban; apixaban; edoxaban; prothrombotic rebound; hypercoagulability; antithrombotic therapy

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MDPI and ACS Style

Frydrych, M.; Janeczek, M.; Małyszek, A.; Nelke, K.; Dobrzyński, M.; Lukaszewski, M. Prothrombotic Rebound After Discontinuation of Direct Oral Anticoagulants Therapy: A Systematic Review. J. Clin. Med. 2024, 13, 6606. https://doi.org/10.3390/jcm13216606

AMA Style

Frydrych M, Janeczek M, Małyszek A, Nelke K, Dobrzyński M, Lukaszewski M. Prothrombotic Rebound After Discontinuation of Direct Oral Anticoagulants Therapy: A Systematic Review. Journal of Clinical Medicine. 2024; 13(21):6606. https://doi.org/10.3390/jcm13216606

Chicago/Turabian Style

Frydrych, Marta, Maciej Janeczek, Agata Małyszek, Kamil Nelke, Maciej Dobrzyński, and Marceli Lukaszewski. 2024. "Prothrombotic Rebound After Discontinuation of Direct Oral Anticoagulants Therapy: A Systematic Review" Journal of Clinical Medicine 13, no. 21: 6606. https://doi.org/10.3390/jcm13216606

APA Style

Frydrych, M., Janeczek, M., Małyszek, A., Nelke, K., Dobrzyński, M., & Lukaszewski, M. (2024). Prothrombotic Rebound After Discontinuation of Direct Oral Anticoagulants Therapy: A Systematic Review. Journal of Clinical Medicine, 13(21), 6606. https://doi.org/10.3390/jcm13216606

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