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10.3390/jcm13216401
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Article

Psoriasis in Childbearing Age: A Real-Life, Retrospective, Single-Center Study on Anti-IL17 and IL-23 Agents

by
Silvia Borriello
†,
Gabriele Roccuzzo
*,†,
Paolo Dapavo
,
Nadia Sciamarrelli
,
Nicole Macagno
,
Francesco Leo
,
Pietro Quaglino
,
Simone Ribero
‡ and
Luca Mastorino
‡
Section of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
*
Author to whom correspondence should be addressed.
†
These authors share first authorship.
‡
These authors share senior authorship.
J. Clin. Med. 2024, 13(21), 6401; https://doi.org/10.3390/jcm13216401
Submission received: 13 September 2024 / Revised: 22 October 2024 / Accepted: 23 October 2024 / Published: 25 October 2024
(This article belongs to the Special Issue Targeted Treatment of Skin Inflammation)
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Abstract

Background: Psoriasis (PSO) involves about 1–3% of the population, and around 75% of women develop PSO before the age of 40. Official guidelines on the treatment of woman with anti-IL17 and anti-IL23 during this potential childbearing time are not currently available. Objective: To investigate the effectiveness and safety of biologic treatments in women of childbearing age. Methods: At the Dermatology Clinic of the University of Turin, Italy, 172 women aged 20–55 years underwent IL-17 and IL-23 inhibitor therapy for moderate-severe PSO and were followed up to 52 weeks in a real-life, retrospective, single-center study. Results: Overall, 40% of patients achieved PASI 100 at week 16, and 72% at week 52. A similar trend was observed for PASI 90 and PASI < 3 with almost 80% and 90% of patients achieving the target at 52 weeks. As for PASI 100, a statistically significant difference (p = 0.004) was found at 16 weeks, with 23.84% of patients achieving PASI 100, with IL-17 and 15.70% with the IL-23 inhibitor. No statistically significant differences were found at 28 and 52 weeks. No statistically significant differences in PASIs at any time points were recorded across the different biologic agents. Forty-six patients discontinued treatment. The most reported side effects were headache, nausea, asthenia, injection site pain, and rhinitis. Conclusions: This study showed that biologic drugs are effective and safe in women of childbearing age, with negligible side effects.
Keywords: psoriasis; biologic therapy; ixekizumab; secukinumab; brodalumab psoriasis; biologic therapy; ixekizumab; secukinumab; brodalumab

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MDPI and ACS Style

Borriello, S.; Roccuzzo, G.; Dapavo, P.; Sciamarrelli, N.; Macagno, N.; Leo, F.; Quaglino, P.; Ribero, S.; Mastorino, L. Psoriasis in Childbearing Age: A Real-Life, Retrospective, Single-Center Study on Anti-IL17 and IL-23 Agents. J. Clin. Med. 2024, 13, 6401. https://doi.org/10.3390/jcm13216401

AMA Style

Borriello S, Roccuzzo G, Dapavo P, Sciamarrelli N, Macagno N, Leo F, Quaglino P, Ribero S, Mastorino L. Psoriasis in Childbearing Age: A Real-Life, Retrospective, Single-Center Study on Anti-IL17 and IL-23 Agents. Journal of Clinical Medicine. 2024; 13(21):6401. https://doi.org/10.3390/jcm13216401

Chicago/Turabian Style

Borriello, Silvia, Gabriele Roccuzzo, Paolo Dapavo, Nadia Sciamarrelli, Nicole Macagno, Francesco Leo, Pietro Quaglino, Simone Ribero, and Luca Mastorino. 2024. "Psoriasis in Childbearing Age: A Real-Life, Retrospective, Single-Center Study on Anti-IL17 and IL-23 Agents" Journal of Clinical Medicine 13, no. 21: 6401. https://doi.org/10.3390/jcm13216401

APA Style

Borriello, S., Roccuzzo, G., Dapavo, P., Sciamarrelli, N., Macagno, N., Leo, F., Quaglino, P., Ribero, S., & Mastorino, L. (2024). Psoriasis in Childbearing Age: A Real-Life, Retrospective, Single-Center Study on Anti-IL17 and IL-23 Agents. Journal of Clinical Medicine, 13(21), 6401. https://doi.org/10.3390/jcm13216401

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