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Systematic Review

Efficacy and Safety of Low-Dose Bisoprolol/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Systematic Review and Meta-Analysis

by
Arrigo F. G. Cicero
1,2,*,
Naif Saad ALGhasab
3,4,
Giuliano Tocci
5,
Giovambattista Desideri
6,
Giulia Fiorini
1,2,* and
Federica Fogacci
1,*
1
Hypertension and Cardiovascular Risk Factors Research Centre, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40100 Bologna, Italy
2
Cardiovascular Medicine Unit, IRCCS AOU BO, 40100 Bologna, Italy
3
Department of Cardiology, Libin Cardiovascular Institute, Calgary University, Calgary, AB T2N 1N4, Canada
4
Department of Internal Medicine, Medical College, Ha’il University, Ha’il 55476, Saudi Arabia
5
Cardiology Unit, Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome ‘La Sapienza’, Sant’Andrea Hospital, 00154 Rome, Italy
6
Department of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(15), 4572; https://doi.org/10.3390/jcm13154572
Submission received: 20 June 2024 / Revised: 28 July 2024 / Accepted: 3 August 2024 / Published: 5 August 2024
(This article belongs to the Special Issue Managing Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Implications)
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Abstract

Objectives: This systematic review and meta-analysis aimed to assess the blood pressure (BP)-lowering effect and the safety profile of low-dose bisoprolol/hydrochlorothiazide combination treatment in patients with hypertension. Methods: Multiple electronic databases were systematically searched, and five clinical studies were included in the meta-analysis. Results: Treatment with bisoprolol/hydrochlorothiazide significantly reduced systolic BP (SBP) [mean difference (MD): −8.35 mmHg, 95% confidence interval (CI): −11.44, −5.25 mmHg versus control; MD: −9.88 mmHg, 95%CI: −12.62, −7.14 mmHg versus placebo] and diastolic BP (DBP) [MD: −7.62 mmHg, 95%CI: −11.20, −4.04 mmHg, versus control; MD: −8.79 mmHg, 95%CI: −11.92, −5.67 mmHg versus placebo]. Moreover, BP response rate and BP control rate after low-dose bisoprolol/hydrochlorothiazide combination treatment were significantly greater compared to control [odd ratio (OR) for response rate: 4.86, 95%CI: 2.52, 9.37; OR for control rate: 1.67, 95%CI: 1.11, 2.51]. Finally, treatment with low-dose bisoprolol/hydrochlorothiazide was associated with a reduced risk of any adverse event (AE) and peripheral edema compared to control. Conclusions: Overall, our results reaffirm the safety and efficiency of prescribing bisoprolol/hydrochlorothiazide combination treatment in stage I and II hypertension.
Keywords: hypertension; blood pressure; bisoprolol; hydrochlorothiazide; meta-analysis hypertension; blood pressure; bisoprolol; hydrochlorothiazide; meta-analysis
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MDPI and ACS Style

Cicero, A.F.G.; ALGhasab, N.S.; Tocci, G.; Desideri, G.; Fiorini, G.; Fogacci, F. Efficacy and Safety of Low-Dose Bisoprolol/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Systematic Review and Meta-Analysis. J. Clin. Med. 2024, 13, 4572. https://doi.org/10.3390/jcm13154572

AMA Style

Cicero AFG, ALGhasab NS, Tocci G, Desideri G, Fiorini G, Fogacci F. Efficacy and Safety of Low-Dose Bisoprolol/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2024; 13(15):4572. https://doi.org/10.3390/jcm13154572

Chicago/Turabian Style

Cicero, Arrigo F. G., Naif Saad ALGhasab, Giuliano Tocci, Giovambattista Desideri, Giulia Fiorini, and Federica Fogacci. 2024. "Efficacy and Safety of Low-Dose Bisoprolol/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 13, no. 15: 4572. https://doi.org/10.3390/jcm13154572

APA Style

Cicero, A. F. G., ALGhasab, N. S., Tocci, G., Desideri, G., Fiorini, G., & Fogacci, F. (2024). Efficacy and Safety of Low-Dose Bisoprolol/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 13(15), 4572. https://doi.org/10.3390/jcm13154572

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