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Volume 13
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10.3390/jcm13154570
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Article

Prognostic Value of Lymph Node Ratio (LNR) in Patients with Postoperative N2 Feature in Non-Small Cell Lung Cancer (NSCLC)

by
Mariusz Piotr Łochowski
1,*,
Justyna Chałubińska-Fendler
2,
Aleksandra Szlachcińska
1,
Barbara Łochowska
3,
Daniel Brzeziński
1,
Jacek Kaczmarski
1 and
Józef Kozak
1
1
Department of Thoracic Surgery and Respiratory Rehabilitation, Medical University of Lodz, Regional Multi-Specialist Center for Oncology and Traumatology, Nicolaus Copernicus Memorial Hospital, 93-513 Lodz, Poland
2
Department of Radiotherapy, Military Institute of Medicine—National Research Inisitute, 04-141 Warsaw, Poland
3
Department of Radiotherapy and General Oncology, Regional Multi-Specialist Center for Oncology and Traumatology, Nicolaus Copernicus Memorial Hospital, 93-513 Lodz, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(15), 4570; https://doi.org/10.3390/jcm13154570
Submission received: 17 June 2024 / Revised: 19 July 2024 / Accepted: 29 July 2024 / Published: 5 August 2024
(This article belongs to the Special Issue Non-small Cell Lung Cancer: Current Updates and Perspectives)
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Abstract

Introduction: One of the most important prognostic factors in non-small cell lung cancer (NSCLC), a condition with a high mortality rate, is the presence of mediastinal lymph node metastases alongside distant metastases. The aim of this study was to evaluate the prognostic value of selected parameters of N2 stage NSCLC with a special focus on lymph node ratio (LNR). Material: The study included 163 patients (61 women and 102 men) operated on due to NSCLC, postoperatively diagnosed as stage N2. The age of the patients ranged from 38 to 82 years (mean age: 62.4 years). The effects of the following factors on clinical data and survival rate were assessed: N1 stage, total number of all metastatic nodes, LNR and LNR N2 ratios, and the presence of skip, single- or multistation metastases. Results: Univariate analysis showed patient survival to be correlated with LNR and LNR N2 ratios, single/multistation metastases, and the number of nodes involved in metastasis. A multivariate model based on patient clinical data found nicotine dependence (p = 0.013), LNR > 0.26 (p = 0.004), and Charlson Comorbidity Index (CCI) value > 3 (p = 0.014) to be independent adverse prognostic factors in this group. Conclusions: LNR ratio is a significant cancer disease-derived independent prognostic factor for patients with postoperative N2 stage NSCLC. In addition, smoking and comorbidities also appear to have prognostic value.
Keywords: non-small cell lung cancer; N2 stage; LNR ratio non-small cell lung cancer; N2 stage; LNR ratio

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MDPI and ACS Style

Łochowski, M.P.; Chałubińska-Fendler, J.; Szlachcińska, A.; Łochowska, B.; Brzeziński, D.; Kaczmarski, J.; Kozak, J. Prognostic Value of Lymph Node Ratio (LNR) in Patients with Postoperative N2 Feature in Non-Small Cell Lung Cancer (NSCLC). J. Clin. Med. 2024, 13, 4570. https://doi.org/10.3390/jcm13154570

AMA Style

Łochowski MP, Chałubińska-Fendler J, Szlachcińska A, Łochowska B, Brzeziński D, Kaczmarski J, Kozak J. Prognostic Value of Lymph Node Ratio (LNR) in Patients with Postoperative N2 Feature in Non-Small Cell Lung Cancer (NSCLC). Journal of Clinical Medicine. 2024; 13(15):4570. https://doi.org/10.3390/jcm13154570

Chicago/Turabian Style

Łochowski, Mariusz Piotr, Justyna Chałubińska-Fendler, Aleksandra Szlachcińska, Barbara Łochowska, Daniel Brzeziński, Jacek Kaczmarski, and Józef Kozak. 2024. "Prognostic Value of Lymph Node Ratio (LNR) in Patients with Postoperative N2 Feature in Non-Small Cell Lung Cancer (NSCLC)" Journal of Clinical Medicine 13, no. 15: 4570. https://doi.org/10.3390/jcm13154570

APA Style

Łochowski, M. P., Chałubińska-Fendler, J., Szlachcińska, A., Łochowska, B., Brzeziński, D., Kaczmarski, J., & Kozak, J. (2024). Prognostic Value of Lymph Node Ratio (LNR) in Patients with Postoperative N2 Feature in Non-Small Cell Lung Cancer (NSCLC). Journal of Clinical Medicine, 13(15), 4570. https://doi.org/10.3390/jcm13154570

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