Autologous Fat Grafting (AFG): A Systematic Review to Evaluate Oncological Safety in Breast Cancer Patients
Abstract
1. Introduction
2. Materials and Methods
3. Results
3.1. Study Selection
3.2. Analysis of Selected Studies
3.3. Comparative Analysis
3.4. Meta-Analysis
Author | Year of Publication | Type of Study | Group | Study Period | Patients (n) | Mean Age (y) | Type of Surgery | Invasive Carcinomas (n) | In Situ Carcinomas (n) | RT before AFG (%) | Mean Surgery-AFG (m) | Mean Follow-up (m) | LRR (%) | LRR (n) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Delay et al. [64] | 2007 | Observational study | BCS + AFG | 2002–2007 | 42 | 51 | BCS + AFG | 35 | 3 | 85.70 | 78 | 31.2 | 4.76 | 2 |
Delaporte et al. [62] | 2008 | Observational study | MST + AFG | 2002–2007 | 15 | 50 | MST + AFG | 9 | 6 | 78.50 | N/A | 27.6 | 0 | 0 |
Rietjens et al. [61] | 2010 | Observational study | BCS + MST + AFG | 2005–2008 | 155 | 48 | BCS + MST + IBR + ABR + AFG | N/A | N/A | 62 | 50.5 | 18.3 | 0.70 | 1 |
Rigotti et al. [18] | 2010 | Retrospective cohort study | MST +AFG | 2000–2005 | 137 | 46.5 | MST +AFG | 105 | 31 | 16.10 | 3.2 | 84 | 3.65 | 5 |
Petit et al. [37] | 2011 | Multicenter retrospective study | BCS + MST + AFG | 2000–2010 | 370 | 52 | BCS + MST +AFG | 87 | 13 | N/A | N/A | 19.2 | 2.16 | 8 |
Petit et al. [59] | 2011 | Matched cohort study | MST | 1997–2008 | 642 | 46 | MST | 568 | 74 | N/A | N/A | 26 | 3 | 19 |
MST + AFG | 321 | 45 | MST + AFG | 284 | 37 | N/A | 26 | 26 | 2.50 | 8 | ||||
Sarfati et al. [58] | 2011 | Prospective study | MST + AFG | 2007–2009 | 28 | 45 | MST + AFG | N/A | N/A | 100 | N/A | 17 | 0 | 0 |
Semprini et al. [57] | 2013 | Observational study | BCS + AFG | 2006–2012 | 151 | N/A | BCS + AFG | N/A | N/A | N/A | 24 | 45 | 0 | 0 |
Riggio et al. [56] | 2013 | Observational study | MST + AFG | 2000–2007 | 60 | 49.7 | MST + AFG | 55 | 5 | 18.30 | 55.2 | 90 | 3.30 | 2 |
Ihrai et al. [55] | 2013 | Retrospective study | MST + AFG | 2004–2009 | 64 | N/A | MST + AFG | 36 | 10 | N/A | N/A | 46.44 | 3.10 | 2 |
Brenelli et al. [54] | 2014 | Prospective study | BCS + AFG | 2005–2008 | 59 | 50 | BCS + AFG | 38 | 7 | 94.90 | N/A | 34.4 | 5.10 | 3 |
Gale et al. [38] | 2014 | Clinical study | BCS + MST | 2007–2013 | 422 | 48.2 | BCS + MST | 368 | 54 | N/A | 54 | 34 | 1.90 | 8 |
BCS + MST + AFG | 211 | 47 | BCS + MST + AFG | 184 | 27 | 108 | 54 | 32 | 0.95 | 2 | ||||
Garcìa et al. [53] | 2014 | Observational study | BCS + AFG | N/A | 37 | 55 | BCS + AFG | 0 | 37 | N/A | 0 | 1 | 0 | 0 |
Kaoutzanis et al. [52] | 2015 | Retrospective study | MST + AFG | 2008–2013 | 108 | 48 | MST + AFG | 68 | 40 | 23.30 | 10.8 | 20.2 | 0 | 0 |
Mestak et al. [30] | 2015 | Prospective study | BCS | 2011–2014 | 45 | 64 | BCS | 41 | 3 | N/A | N/A | 56 | 4.88 | 2 |
BCS + AFG | 32 | 53 | BCS + AFG | 25 | 4 | 100 | 77 | 56 | 6.25 | 2 | ||||
Silva-Vergara et al. [51] | 2015 | Retrospective study | BCS + MST + AFG | 2007–2015 | 195 | 52 | BCS + MST + AFG | 161 | 44 | 100 | 4 | 3.3 | 3.58 | 7 |
Masia et al. [45] | 2015 | Retrospective study case-control | MST + ABR | 1989–2017 | 107 | 49 | MST + ABR | 87 | 16 | N/A | N/A | 29 | 5.60 | 6 |
MST + ABR + AFG | 107 | 49.19 | MST + ABR + AFG | 85 | 14 | N/A | N/A | 29 | 2.80 | 3 | ||||
Kronowitz et al. [44] | 2016 | Retrospective cohort study | MST | 2001–2014 | 670 | 46.5 | MST | 548 | 61 | N/A | N/A | 43.8 | 4.10 | 27 |
BCS + MST + AFG | 719 | 47.1 | BCS + MST + AFG | 552 | 108 | 38.50 | 2.63 | 59.6 | 1.60 | 12 | ||||
Myckatyn et al. [50] | 2016 | Multicenter case cohort study | MST + AFG | 2006–2011 | 1197 | 47 | MST + IBR + ABR | N/A | N/A | N/A | N/A | N/A | 11.00% | 24 |
Petit et al. [36] | 2016 | Matched case-control study | MST | 2006–2013 | 322 | N/A | MST + BCS | 322 | 0 | 86 | N/A | 52.8 | 5 | 16 |
MST + AFG | 322 | N/A | MST + BCS + AFG | 322 | 0 | 84 | N/A | 57.6 | 4.30 | 14 | ||||
Arjen et al. [63] | 2017 | Retrospective cohort study | BCS + AFG | 2008–2016 | 109 | 55 | BCS + AFG | N/A | N/A | 100 | 18 | 26.4 | 0 | 0 |
Fertsch et al. [35] | 2017 | Matched retrospective cohort study | MST + DIEP | 2009–2013 | 100 | 50.7 | MST + ABR | 91 | 9 | N/A | N/A | 31 | 12 | 12 |
MST + DIEP + AFG | 100 | 49.6 | MST + ABR + AFG | 91 | 9 | 73 | 40.5 | 32 | 13 | 13 | ||||
Krastev et al. [34] | 2018 | Matched cohort study | MST + BCS | 2006–2014 | 300 | 49.4 | MST + BCS | 260 | 40 | N/A | N/A | 52.8 | 3.60 | 11 |
MST + BCS + AFG | 300 | 48.1 | MST + BCS + AFG | 261 | 39 | 60 | N/A | 60 | 2.60 | 8 | ||||
Upadhyaya et al. [43] | 2018 | Retrospective chart review study | MST | 2011–2016 | 449 | N/A | MST + IBR + ABR | N/A | N/A | N/A | N/A | 26 | 1.70 | 8 |
MST + AFG | 171 | 50.51 | MST + IBR + ABR + AFG | N/A | N/A | N/A | N/A | 26 | 0 | 0 | ||||
Calabrese et al. [29] | 2018 | Prospective multi arm single center cohort study | MST | 2008–2011 | 72 | 47.7 | MST | N/A | N/A | N/A | N/A | 72 | 1.60 | 1 |
MST + AFG | 57 | 50.3 | MST + AFG | N/A | N/A | 9 | 9 | 75 | 4.70 | 3 | ||||
MST + EAFG | 54 | 48.8 | MST +EAFG | N/A | N/A | 17 | 10 | 84 | 2.40 | 1 | ||||
Sorrentino et al. [28] | 2019 | Retrospective exact matching study | MST + BCS | 2007–2017 | 597 | 50.7 | MST + BCS | 535 | 62 | N/A | N/A | 63.8 | 5.00% | 30 |
MST + BCS + AFG | 233 | 49.4 | MST + BCS + AFG | 207 | 26 | 45.90 | 22.9 | 74.1 | 6.40 | 15 | ||||
Knackstedt et al. [49] | 2019 | Retrospective cohort study | MST + IBR + AFG | 2006–2015 | 166 | 52 | MST + IBR + AFG | 106 | 52 | 20 | N/A | 28 | 0 | 0 |
Stumpf et al. [27] | 2020 | Matched retrospective cohort study | BCS | 2004–2016 | 255 | 54 | BCS | 255 | 0 | N/A | N/A | 60 | 8.60 | 22 |
BCS + AFG | 65 | 53 | BCS + AFG | 65 | 0 | N/A | N/A | 60 | 12.30 | 8 | ||||
Vyas et al. [33] | 2020 | Matched case-control study | MST | 2000–2017 | 69 | N/A | MST | N/A | N/A | N/A | N/A | 42.5 | 8.50 | 6 |
MST +AFG | 29 | 48.6 | MST + AFG | N/A | N/A | 27.4 | N/A | 42.5 | 8.20 | 2 | ||||
Dile et al. [48] | 2021 | Retrospective study | MST + BCS + AFG | 2013–2016 | 252 | 50 | MST + BCS + ABR + IBR + AFG | N/A | N/A | 73.50 | 35 | 27 | 2.40 | 6 |
Kempa et al. [47] | 2021 | Monocentric cohort study | MST + BCS + AFG | 2008–2020 | 90 | 46.1 | MST + BCS + AFG | 77 | 13 | 13 | 57 | 80 | 0.90 | 1 |
De Berti et al. [26] | 2021 | Retrospective monocentric case-control study | MST | 2007–2017 | 303 | 52 | MST + BCS + ABR + IBR | 202 | 87 | N/A | N/A | N/A | 6.60 | 20 |
MST + AFG | 109 | 50 | MST + BCS + ABR +IBR + AFG | 89 | 16 | N/A | N/A | N/A | 8.30 | 9 | ||||
Tukiama et al. [32] | 2021 | Retrospective matched cohort study | MST | 2007–2016 | 126 | N/A | MST + BCS | N/A | N/A | N/A | N/A | 65 | 7.10 | 9 |
MST + AFG | 42 | N/A | MST + BCS + AFG | N/A | N/A | N/A | N/A | 65 | 6.30% | 3 | ||||
Chung et al. [31] | 2021 | Retrospective cohort study | MST | 2009–2019 | 272 | 50.4 | MST + BCS + ABR + IBR | 200 | 66 | N/A | N/A | 52 | 6 | 16 |
MST + AFG | 67 | 50.4 | MST + BCS + ABR + IBR + AFG | 52 | 15 | 18 | N/A | 52 | 15 | 10 | ||||
Sorotos et al. [42] | 2021 | Retrospective matched case control study | MST | 2005–2017 | 494 | 45 -49 | MST + IBR + ABR | 379 | 115 | N/A | N/A | 36 | 9.60 | 47 |
MST + AFG | 425 | 45–49 | MST + IBR + ABR + AFG | 324 | 101 | N/A | N/A | 36 | 3 | 13 | ||||
Klinger et al. [41] | 2021 | Retrospective multicenter study case- control | MST + BCS | 2000–2018 | 923 | 52.9 | MST + BCS | 923 | N/A | N/A | N/A | 58 | 6.10 | 56 |
MST +BCS + AFG | 466 | 51.4 | MST + BCS + AFG | 466 | N/A | 65 | N/A | 63 | 3.90 | 18 | ||||
Casarrubios et al. [40] | 2021 | Matched cohort study | MST | 2011–2019 | 125 | 47.2 | MST + BCS | 115 | 10 | N/A | N/A | 85 | 4 | 5 |
MST + AFG | 125 | 45.6 | MST + BCS + AFG | 106 | 19 | 87.20 | 48.1 | 95.3 | 2.40 | 3 | ||||
Cohen et al. [46] | 2021 | Retrospective cohort study | MST + AFG | 2010–2015 | 248 | 47.95 | MST + AFG | 111 | 51 | 36 | 13.2 | 45.6 | 2.40 | 6 |
Lee et al. [25] | 2022 | Retrospective cohort study | MST | 2011–2016 | 126 | 43.9 | MST + IBR | N/A | N/A | N/A | N/A | N/A | 9 | 11 |
MST + AFG | 141 | 43.9 | MST + IBR + AFG | N/A | N/A | 2.70 | 12 | N/A | 17 | 24 | ||||
Gong et al. [39] | 2022 | Retrospective cohort study | BCS | 2018 | 40 | 50.8 | BCS | 36 | 4 | N/A | N/A | 40.28 | 10 | 8 |
BCS + AFG | 40 | 50.2 | BCS + AFG | 38 | 2 | N/A | N/A | 40.58 | 7.50 | 3 |
4. Discussion
5. Future Directions
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patients (No.) | LRR (No) | LRR (%) | |
---|---|---|---|
MST/BCS + AFG | 7619 | 240 | 3.15% |
MST/BCS | 6459 | 342 | 5.30% |
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Lo Torto, F.; Patanè, L.; Abbaticchio, D.; Pagnotta, A.; Ribuffo, D. Autologous Fat Grafting (AFG): A Systematic Review to Evaluate Oncological Safety in Breast Cancer Patients. J. Clin. Med. 2024, 13, 4369. https://doi.org/10.3390/jcm13154369
Lo Torto F, Patanè L, Abbaticchio D, Pagnotta A, Ribuffo D. Autologous Fat Grafting (AFG): A Systematic Review to Evaluate Oncological Safety in Breast Cancer Patients. Journal of Clinical Medicine. 2024; 13(15):4369. https://doi.org/10.3390/jcm13154369
Chicago/Turabian StyleLo Torto, Federico, Luca Patanè, Donato Abbaticchio, Alessia Pagnotta, and Diego Ribuffo. 2024. "Autologous Fat Grafting (AFG): A Systematic Review to Evaluate Oncological Safety in Breast Cancer Patients" Journal of Clinical Medicine 13, no. 15: 4369. https://doi.org/10.3390/jcm13154369
APA StyleLo Torto, F., Patanè, L., Abbaticchio, D., Pagnotta, A., & Ribuffo, D. (2024). Autologous Fat Grafting (AFG): A Systematic Review to Evaluate Oncological Safety in Breast Cancer Patients. Journal of Clinical Medicine, 13(15), 4369. https://doi.org/10.3390/jcm13154369