Young Women with Early-Stage Breast Cancer Treated with Upfront Surgery: Overview of Oncological Outcomes
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patients | 130 |
Age (years) | 36 (25–40) |
Histologic subtype | |
- Ductal invasive carcinoma | 117 (90.0%) |
- Lobular invasive carcinoma | 8 (6.1%) |
- Others | 5 (3.9%) |
Grading | |
- 1 | 18 (13.8%) |
- 2 | 67 (51.6%) |
- 3 | 45 (34.6%) |
Stage | |
- pT1mi | 6 (4.6%) |
- pT1a | 6 (4.6%) |
- pT1b | 33 (25.4%) |
- pT1c | 85 (65.4%) |
- pN0 | 89 (68.5%) |
- pN0 (i+) | 4 (3.0%) |
- pN1mi | 13 (10%) |
- pN1 | 21 (16.2%) |
- pN2 | 3 (2.3%) |
- Multifocal | 37 (28.5%) |
Biological subtypes | |
- Luminal-like | 95 (73.1%) |
- HER2-enriched | 18 (13.8%) |
- Triple-negative | 17 (13.1%) |
Adjuvant treatment | |
- Radiotherapy | 95 (73.0%) |
- Hormone therapy | 106 (81.5%) |
- Chemotherapy | 57 (43.9%) |
Surgical treatment | |
- Breast-conserving surgery | 92 (70.8%) |
- Conservative mastectomy | 38 (29.2%) |
- SLNB | 107 (82.3%) |
- ALND | 23 (17.7%) |
BRCA 1 | 15 (11.5%) |
BRCA 2 | 2 (1.5%) |
LRFS p-Value (Chi-Square) | DMFS p-Value (Chi-Square) | DFS p-Value (Chi-Square) | OS p-Value (Chi-Square) | |
---|---|---|---|---|
Tumor Subtype | 0.763 | 0.442 | 0.981 | 0.315 |
(0.613) | (1.632) | (0.039) | (2.313) | |
Grading | 0.454 | 0.412 | 0.320 | 0.842 |
(1.581) | (1.774) | (2.276) | (0.345) | |
Type of Surgery | 0.011 | 0.370 | 0.026 | 0.472 |
(6.420) | (0.803) | (4.927) | (0.518) |
Mastectomy | BCS | |
---|---|---|
Patients | 38 (29.2%) | 92 (70.8%) |
Age (years) | 36.7 (25–40) | 36.9 (27–40) |
Histologic subtype | ||
- Ductal invasive carcinoma | 36 (94.8%) | 81 (88%) |
- Lobular invasive carcinoma | 2 (5.2%) | 6 (6.5%) |
- Others | 0 (%) | 5 (5.5%) |
Grading | ||
- 1 | 5 (13.2%) | 13 (14.2%) |
- 2 | 19 (50%) | 48 (52.2%) |
- 3 | 14 (36.8%) | 31 (33.6%) |
Stage | ||
- pT1mi | 3 (8%) | 3 (3.3%) |
- pT1a | 5 (13.2%) | 1 (1%) |
- pT1b | 7 (18.4%) | 26 (28.3%) |
- pT1c | 23 (60.4%) | 62 (67.4%) |
- pN0 | 26 (68.5%) | 63 (68.5%) |
- pN0 (i+) | 0 (%) | 4 (4.4%) |
- pN1mi | 2 (5.2%) | 11 (11.9%) |
- pN1 | 10 (26.3%) | 11 (11.9%) |
- pN2 | 0 (%) | 3 (3.3%) |
- Multifocal | 18 (47.4%) | 19 (20.7%) |
Biological subtypes | ||
- Luminal-like | 27 (71%) | 68 (74%) |
- HER2-enriched | 4 (10.6%) | 14 (15.2%) |
- Triple-negative | 7 (18.4%) | 10 (10.9%) |
Adjuvant treatment | ||
- Radiotherapy | 7 (18.4%) | 88 (95.6%) |
- Hormone therapy | 26 (68.5%) | 80 (87%) |
- Chemotherapy | 22 (57.9%) | 35 (38%) |
Axillary surgery | ||
- SLNB | 27 (71%) | 80 (87%) |
- ALND | 11 (29%) | 12 (13%) |
BRCA 1 | 9 (23.7%) | 6 (6.5%) |
BRCA 2 | 1 (2.6%) | 1 (1%) |
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Scardina, L.; Carnassale, B.; Di Leone, A.; Sanchez, A.M.; Biondi, E.; Moschella, F.; D’Archi, S.; Franco, A.; De Lauretis, F.; Di Guglielmo, E.; et al. Young Women with Early-Stage Breast Cancer Treated with Upfront Surgery: Overview of Oncological Outcomes. J. Clin. Med. 2024, 13, 3966. https://doi.org/10.3390/jcm13133966
Scardina L, Carnassale B, Di Leone A, Sanchez AM, Biondi E, Moschella F, D’Archi S, Franco A, De Lauretis F, Di Guglielmo E, et al. Young Women with Early-Stage Breast Cancer Treated with Upfront Surgery: Overview of Oncological Outcomes. Journal of Clinical Medicine. 2024; 13(13):3966. https://doi.org/10.3390/jcm13133966
Chicago/Turabian StyleScardina, Lorenzo, Beatrice Carnassale, Alba Di Leone, Alejandro Martin Sanchez, Ersilia Biondi, Francesca Moschella, Sabatino D’Archi, Antonio Franco, Flavia De Lauretis, Enrico Di Guglielmo, and et al. 2024. "Young Women with Early-Stage Breast Cancer Treated with Upfront Surgery: Overview of Oncological Outcomes" Journal of Clinical Medicine 13, no. 13: 3966. https://doi.org/10.3390/jcm13133966
APA StyleScardina, L., Carnassale, B., Di Leone, A., Sanchez, A. M., Biondi, E., Moschella, F., D’Archi, S., Franco, A., De Lauretis, F., Di Guglielmo, E., Petrazzuolo, E., Magno, S., Masetti, R., & Franceschini, G. (2024). Young Women with Early-Stage Breast Cancer Treated with Upfront Surgery: Overview of Oncological Outcomes. Journal of Clinical Medicine, 13(13), 3966. https://doi.org/10.3390/jcm13133966