Impact of Post-Operative Infection after CABG on Long-Term Survival
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Survivors n = 560 | Non-Survivors n = 228 | p |
---|---|---|---|
Female (n. %) | 138/560 (25%) | 51/228 (22%) | 0.8974 |
Age (years. mean ± SD) | 63 (9) | 69 (8) | <0.0001 |
Weight (kg. mean ± SD) | 81 (13) | 80 (14) | 0.6957 |
LVEF (%. mean ± SD) | 51 (10) | 46 (12) | 0.0001 |
Insulin-dependent diabetes (n. %) | 6/553 (1.1%) | 2/228 (0.9%) | 1 |
Insulin-non-dependent diabetes (n. %) | 159/553 (29%) | 92/228 (40%) | 0.0134 |
Prior stroke (n. %) | 18/553 (3.3%) | 19/228 (8.3%) | 0.0178 |
Myocardial infarction (n. %) | 169/552 (31%) | 96/228 (42%) | 0.0143 |
Atrial fibrillation (n. %) | 12/553 (2.2%) | 14/228 (6.1%) | 0.0352 |
NYHA functional class (n. %) | 0.0170 | ||
1 | 4/542 (0.7%) | 0/226 (0%) | |
2 | 122/542 (23%) | 28/226 (12%) | |
3 | 290/542 (54%) | 146/226 (65%) | |
4 | 126/542 (23%) | 52/226 (23%) | |
ES (mean ± SD) | 3.36 (2.48) | 5.13 (2.81) | <0.0001 |
ES log (mean ± SD) | 3.9 (4.2) | 7.2 (6.8) | <0.0001 |
Peripheral arterial disease (n. %) | 43/553 (7.8%) | 44/228 (19%) | <0.0001 |
Renal failure (n. %) | 13/553 (2.4%) | 21/228 (9.2%) | 0.0004 |
CPB time (minutes. mean ± SD) | 50 (15) | 50 (15) | 0.8031 |
Operation time (minutes. mean ± SD) | 153 (56) | 150 (26) | 0.8031 |
LVEF day after surgery % | 53 (9) | 47 (11) | <0.0001 |
CK-MB after 6 h | 37 (20) | 43 (38) | 0.5946 |
CK-MB after 12 h | 42 (32) | 53 (70) | 0.2007 |
CK-MB after 24 h | 44 (35) | 59 (100) | 0.1307 |
Intraaortic balloon pump (n. %) | 2/548 (0.4%) | 2/227 (0.9%) | 0.98331 |
Milrinone (n. %) | 11/541 (2.0%) | 9/222 (4.1%) | 0.48196 |
TIA (n. %) | 5/551 (0.9%) | 0/227 (0%) | 0.63631 |
Post-operative myocardial infarction (n. %) | 6/551 (1.1%) | 7/227 (3.1%) | 0.27267 |
Post-operative stroke (n. %) | 2/551 (0.4%) | 5/227 (2.2%) | 0.13234 |
Post-operative atrial fibrillation (n. %) | 119/551 (22%) | 58/227 (26%) | 0.55622 |
Infection (n. %) | 30/559 (5.4%) | 39/228 (17%) | <0.0001 |
Infection source (n. %) | <0.0001 | ||
0 | 529/559 (95%) | 189/228 (83%) | |
BSI | 6/559 (1.1%) | 9/228 (3.9%) | |
SSI sternal | 9/559 (1.6%) | 6/228 (2.6%) | |
SSI leg | 2/559 (0.4%) | 1/228 (0.4%) | |
Pneumonia | 13/559 (2.3%) | 23/228 (10%) | |
Post-operative drainage (mL. mean ± SD) | 552 (353) | 530 (306) | 0.9020 |
Red blood cells (mL. mean ± SD) | 124 (271) | 181 (326) | 0.0363 |
Parameter | Infection (−) | Infection (+) | p |
---|---|---|---|
Female (n. %) | 176/718 (25%) | 13/69 (19%) | 0.6571 |
Age (years. mean ± SD) | 65 (9) | 68 (9) | 0.0051 |
Weight (kg. mean ± SD) | 81 (13) | 84 (13) | 0.06332 |
LVEF (%. mean ± SD) | 50 (11) | 46 (12) | 0.0313 |
ES (mean ± SD) | 3.71 (2.60) | 5.60 (3.12) | <0.0001 |
ES log (mean ± SD) | 4.5 (4.7) | 8.3 (9.2) | <0.0001 |
Insulin-dependent diabetes (n. %) | 7/713 (1.0%) | 1/67 (1.5%) | 1 |
Insulin-non-dependent diabetes (n. %) | 218/713 (31%) | 32/67 (48%) | 0.0411 |
Prior stroke (n. %) | 33/713 (4.6%) | 4/67 (6.0%) | 1 |
Myocardial infarction (n. %) | 242/712 (34%) | 23/67 (34%) | 1 |
Atrial fibrillation (n. %) | 22/713 (3.1%) | 4/67 (6.0%) | 0.6571 |
Hypertension (n. %) | |||
NYHA functional class (n. %) | 0.02625 | ||
1 | 4/700 (0.6%) | 0/67 (0%) | |
2 | 145/700 (21%) | 5/67 (7.5%) | |
3 | 400/700 (57%) | 36/67 (54%) | |
4 | 151/700 (22%) | 26/67 (39%) | |
Peripheral arterial disease (n. %) | 75/713 (11%) | 12/67 (18%) | 0.3156 |
Renal failure (n. %) | 29/713 (4.1%) | 5/67 (7.5%) | 0.6458 |
Intraaortic balloon pump (n. %) | 2/709 (0.3%) | 2/65 (3.1%) | 0.1683 |
Milrinone (n. %) | 11/696 (1.6%) | 9/66 (14%) | <0.0001 |
TIA (n. %) | 4/711 (0.6%) | 1/66 (1.5%) | 1 |
Post-operative myocardial infarction (n. %) | 8/711 (1.1%) | 5/66 (7.6%) | 0.0074 |
Post-operative stroke (n. %) | 6/711 (0.8%) | 1/66 (1.5%) | 1 |
Post-operative atrial fibrillation (n. %) | 160/711 (23%) | 16/66 (24%) | 1 |
CPB time (minutes. mean ± SD) | 50 (14) | 52 (18) | 0.8494 |
Operation time (minutes. mean ± SD) | 151 (50) | 157 (33) | 0.1689 |
LVEF day after surgery % | 52 (10) | 45 (11) | <0.0001 |
Chest drainage time (hours. mean ± SD) | 29 (15) | 31 (17) | 0.9266 |
CK-MB after 6 h | 37 (21) | 56 (59) | 0.0373 |
CK-MB after 12 h | 42 (33) | 71 (113) | 0.0212 |
CK-MB after 24 h | 45 (38) | 82 (163) | 0.0068 |
Post-operative drainage (mL. mean ± SD) | 544 (334) | 568 (403) | 0.8015 |
Red blood cells (mL. mean ± SD) | 130 (278) | 251 (366) | 0.0058 |
Time of in-hospital stay (days mean ± SD) | 7.2 (1.7) | 13.7 (13.4) | 0.0001 |
ICU admission (n. %) | 4/718 (0.6) | 20/69 (28.9) | <0.0001 |
In-hospital mortality (n. %) | 4/718 9(0.6) | 8/69 (11.6) | <0.0001 |
Parameter | Survivors n = 560 | Non-survivors n = 228 | p |
---|---|---|---|
Female (n. %) | 138/560 (25%) | 51/228 (22%) | 0.8974 |
Age (years. Mean ± SD) | 63 (9) | 69 (8) | <0.0001 |
Weight (kg. mean ± SD) | 81 (13) | 80 (14) | 0.6957 |
LVEF (%. Mean ± SD) | 51 (10) | 46 (12) | 0.0001 |
Insulin-dependent diabetes (n. %) | 6/553 (1.1%) | 2/228 (0.9%) | 1 |
Insulin-non-dependent diabetes (n. %) | 159/553 (29%) | 92/228 (40%) | 0.0134 |
Prior stroke (n. %) | 18/553 (3.3%) | 19/228 (8.3%) | 0.0178 |
Myocardial infarction (n. %) | 169/552 (31%) | 96/228 (42%) | 0.0143 |
Atrial fibrillation (n. %) | 12/553 (2.2%) | 14/228 (6.1%) | 0.0352 |
NYHA functional class (n. %) | 0.0170 | ||
1 | 4/542 (0.7%) | 0/226 (0%) | |
2 | 122/542 (23%) | 28/226 (12%) | |
3 | 290/542 (54%) | 146/226 (65%) | |
4 | 126/542 (23%) | 52/226 (23%) | |
ES (mean ± SD) | 3.36 (2.48) | 5.13 (2.81) | <0.0001 |
ES log (mean ± SD) | 3.9 (4.2) | 7.2 (6.8) | <0.0001 |
Peripheral arterial disease (n. %) | 43/553 (7.8%) | 44/228 (19%) | <0.0001 |
Renal failure (n. %) | 13/553 (2.4%) | 21/228 (9.2%) | 0.0004 |
CPB time (minutes. Mean ± SD) | 50 (15) | 50 (15) | 0.8031 |
Operation time (minutes. Mean ± SD) | 153 (56) | 150 (26) | 0.8031 |
LVEF day after surgery % | 53 (9) | 47 (11) | <0.0001 |
CK-MB after 6 h | 37 (20) | 43 (38) | 0.5946 |
CK-MB after 12 h | 42 (32) | 53 (70) | 0.2007 |
CK-MB after 24 h | 44 (35) | 59 (100) | 0.1307 |
Intraaortic balloon pump (n. %) | 2/548 (0.4%) | 2/227 (0.9%) | 0.98331 |
Milrinone (n. %) | 11/541 (2.0%) | 9/222 (4.1%) | 0.48196 |
TIA (n. %) | 5/551 (0.9%) | 0/227 (0%) | 0.63631 |
Post-operative myocardial infarction (n. %) | 6/551 (1.1%) | 7/227 (3.1%) | 0.27267 |
Post-operative stroke (n. %) | 2/551 (0.4%) | 5/227 (2.2%) | 0.13234 |
Post-operative atrial fibrillation (n. %) | 119/551 (22%) | 58/227 (26%) | 0.55622 |
Infection (n. %) | 30/559 (5.4%) | 39/228 (17%) | <0.0001 |
Infection source (n. %) | <0.0001 | ||
0 | 529/559 (95%) | 189/228 (83%) | |
BSI | 6/559 (1.1%) | 9/228 (3.9%) | |
SSI sternal | 9/559 (1.6%) | 6/228 (2.6%) | |
SSI leg | 2/559 (0.4%) | 1/228 (0.4%) | |
Pneumonia | 13/559 (2.3%) | 23/228 (10%) | |
Post-operative drainage (mL. mean ± SD) | 552 (353) | 530 (306) | 0.9020 |
Red blood cells (mL. mean ± SD) | 124 (271) | 181 (326) | 0.0363 |
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Zukowska, A.; Kaczmarczyk, M.; Listewnik, M.; Zukowski, M. Impact of Post-Operative Infection after CABG on Long-Term Survival. J. Clin. Med. 2023, 12, 3125. https://doi.org/10.3390/jcm12093125
Zukowska A, Kaczmarczyk M, Listewnik M, Zukowski M. Impact of Post-Operative Infection after CABG on Long-Term Survival. Journal of Clinical Medicine. 2023; 12(9):3125. https://doi.org/10.3390/jcm12093125
Chicago/Turabian StyleZukowska, Agnieszka, Mariusz Kaczmarczyk, Mariusz Listewnik, and Maciej Zukowski. 2023. "Impact of Post-Operative Infection after CABG on Long-Term Survival" Journal of Clinical Medicine 12, no. 9: 3125. https://doi.org/10.3390/jcm12093125
APA StyleZukowska, A., Kaczmarczyk, M., Listewnik, M., & Zukowski, M. (2023). Impact of Post-Operative Infection after CABG on Long-Term Survival. Journal of Clinical Medicine, 12(9), 3125. https://doi.org/10.3390/jcm12093125