Severity and Longitudinal Course of Depression, Anxiety and Post-Traumatic Stress in Paediatric and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Protocol and Guidance
2.2. Data Sources and Search Strategy
2.3. Study Selection: Inclusion and Exclusion Criteria
2.4. Data Extraction
2.5. Risk of Bias Assessment
2.6. Data Analysis
3. Results
3.1. Longitudinal Course of Depressive Symptoms after Diagnosis of Cancer
3.2. Risk, Protective and Exacerbating of Depressive Symptoms
3.3. Longitudinal Course of Anxiety Symptoms after Diagnosis of Cancer
3.4. Risk, Protective and Exacerbating of Anxiety Symptoms
3.5. PTSS after Diagnosis of Cancer
3.6. Risk of Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author | Publication Year | Region of Study | N, Cancer Type | Control Characteristics | Age at Cancer Diagnosis * | Age at the Time Data Were Collected * | Depression Scale | Anxiety Scale | Post-Traumatic Stress Scales |
---|---|---|---|---|---|---|---|---|---|
Kunin-Batson et al. [26] | 2016 | USA | 160, Acute lymphocytic leukaemia | Normative population data | Range: 1–9.9 | Range: 2–10.9 | BASC-2 | BASC-2 | - |
Myers et al. [27] | 2014 | USA | 159, Acute lymphocytic leukaemia | Normative population data | 4.9 (2.2) | 5.9 (2.2) | BASC-2 | BASC-2 | - |
Gupta et al. [38] | 2014 | India | 40, Acute lymphocytic leukaemia | Matched controls | Range: 6 to 14 | Range: 6 to 14 | CPMS | CPMS | - |
Werk et al. [32] | 2022 | USA | 1721, Hodgkin’s lymphoma | No reference group | 14.6 (3.3) | 14.5 (3.4) | - | - | Novel scale |
Kaplan et al. [36] | 1987 | USA | 21, Haematological cancers | Matched controls | 9.71 (1.52) | 15.4 (1.82) | CDI and BDI | - | - |
Desjardins et al. [33] | 2019 | Canada | 91, Central nervous system | Caregivers | NR | 11.21 (2.8) | BASC-2 | BASC-2 | - |
Monteiro et al. [37] | 2013 | Portugal | 11, Various | Matched controls | NR | NR | HADS | HADS | - |
Prikken et al. [34] | 2022 | Belgium | 125, Various | Parents | 14 to 19 years | NR | CES-D | - | - |
Kwak et al. [35] | 2013 | USA | 87, Various | No comparison group | 22.7 | 23.2 | - | - | PDS, BSI-18 and SF-36 |
Sargin Yildirim et al. [28] | 2017 | Turkey | 50, Various | Parents | 12.14 (2.97) | 12.39 (2.97) | CDI | SCARED | - |
Jorngarden et al. [29] | 2007 | Sweden | 56, Various | General population | 15.7 | NR | HADS | HADS | - |
Larsson et al. [30] | 2010 | Sweden | 61, Various | Normative population data | Range: 13–19 | 4 years after diagnosis | HADS | HADS | - |
Yardeni et al. [31] | 2021 | Israel | 99, Various | Parents | NR | 13.56 (3.63) | PROMIS and K-SADS | PROMIS and K-SADS | - |
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Lee, A.R.Y.B.; Yau, C.E.; Low, C.E.; Li, J.; Ho, R.C.M.; Ho, C.S.H. Severity and Longitudinal Course of Depression, Anxiety and Post-Traumatic Stress in Paediatric and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis. J. Clin. Med. 2023, 12, 1784. https://doi.org/10.3390/jcm12051784
Lee ARYB, Yau CE, Low CE, Li J, Ho RCM, Ho CSH. Severity and Longitudinal Course of Depression, Anxiety and Post-Traumatic Stress in Paediatric and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2023; 12(5):1784. https://doi.org/10.3390/jcm12051784
Chicago/Turabian StyleLee, Ainsley Ryan Yan Bin, Chun En Yau, Chen Ee Low, Jiaqi Li, Roger C. M. Ho, and Cyrus Su Hui Ho. 2023. "Severity and Longitudinal Course of Depression, Anxiety and Post-Traumatic Stress in Paediatric and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 12, no. 5: 1784. https://doi.org/10.3390/jcm12051784