Multidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group I | Group II | p | |
n = 38 Unique Patients | n = 24 Unique Patients | ||
Age, Yrs (median, IQR) | 33.5 (29.25–49) | 33.5 (25–43) | 0.699 |
Gender, Female n, (%) | 8 (21.1) | 10 (41.7) | 0.084 |
Reduced EF n, (%) | 1 (2.6) | 6 (25) | 0.007 |
Hepatitis C n, (%) | 26 (68.4) | 16 (66.7) | 0.890 |
HIV n, (%) | 3 (7.9) | 1 (4.2) | 0.567 |
Group I | Group II | p | |
n = 43 IE-CS episodes | n = 24 IE-CS episodes | ||
Pre-surgery | |||
Paced Rhythm n, (%) | 3 (6.9) | 2 (8.3) | 1 |
Methadone n, (%) | 16 (37.2) | 18 (75) | 0.005 |
Buprenorphine n, (%) | 4 (9.3) | 3 (12.5) | 0.695 |
Surgery | |||
Paced Rhythm n, (%) | 5 (11.6) | 6 (25) | 0.31 |
Methadone n, (%) | 14 (32.6) | 20 (83.3) | <0.001 |
Buprenorphine n, (%) | 1 (2.3) | 2 (8.3) | 0.29 |
Peri-discharge | |||
Paced Rhythm n, (%) | 11 (25.6) | 8 (33.3) | 0.576 |
Methadone n, (%) | 18 (41.9) | 19 (79.2) | 0.005 |
Buprenorphine n, (%) | 0 (0) | 4 (16.7) | 0.014 |
Methadone Dose (mg/day) | Pre-Surgery | Surgery | Peri-Discharge | p (within) |
---|---|---|---|---|
Group I (median, IQR) | 70 (40–95) | 65 (30–90) | 85 (30–90) | 0.890 |
Group II (median, IQR) | 47.5 (30–75) | 47.5 (30–65) | 60 (50–90) | 0.484 |
p (between) | 0.271 | 0.653 | 0.984 |
Pts with VF | Pts without VF | |
n | 6 | 56 |
Gender, Female, n (%) | 4 (66) | 14 (25) |
Methadone use *, n (%) | 2 (33) | 34 (61) |
Buprenorphine use at D/C, n (%) | 0 (0) | 4 (7) |
Pacemaker issues, n (%) | 3 (50) | 0 (0) |
Corrected QTc: | PM with VF | PM without VF |
n = 5 | n = 14 | |
Pre-surgery cQTc, ms (mean) | 477 | 466 |
Surgery cQTc, ms (mean) | 484 | 448 |
Peri-discharge cQTc, ms (mean) | 451 | 414 |
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Rosenfeld, L.E.; Jain, S.; Amabile, A.; Geirsson, A.; Krane, M.; Weimer, M.B. Multidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation. J. Clin. Med. 2023, 12, 882. https://doi.org/10.3390/jcm12030882
Rosenfeld LE, Jain S, Amabile A, Geirsson A, Krane M, Weimer MB. Multidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation. Journal of Clinical Medicine. 2023; 12(3):882. https://doi.org/10.3390/jcm12030882
Chicago/Turabian StyleRosenfeld, Lynda E., Shashank Jain, Andrea Amabile, Arnar Geirsson, Markus Krane, and Melissa B. Weimer. 2023. "Multidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation" Journal of Clinical Medicine 12, no. 3: 882. https://doi.org/10.3390/jcm12030882
APA StyleRosenfeld, L. E., Jain, S., Amabile, A., Geirsson, A., Krane, M., & Weimer, M. B. (2023). Multidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation. Journal of Clinical Medicine, 12(3), 882. https://doi.org/10.3390/jcm12030882