Cross-Cultural Adaptation and Validation of the Methotrexate Intolerance Severity Score Questionnaire in Portuguese (Brazil) for Children and Adolescents with Juvenile Idiopathic Arthritis
Abstract
1. Introduction
2. Materials and Methods
2.1. Translation and Transcultural Adaptation
2.2. Statistical Analysis
3. Results
3.1. Descriptive Data
3.2. Cross-Cultural Adaptation
3.3. Psychometric Issues
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Item | Total Item Correlation | Cronbach’s Alpha |
---|---|---|
1 | 0.62 | 0.87 |
2 | 0.46 | 0.78 |
3 | 0.64 | 0.76 |
4 | 0.72 | 0.75 |
5 | 0.67 | 0.76 |
6 | 0.68 | 0.75 |
7 | 0.61 | 0.76 |
8 | 0.47 | 0.77 |
9 | 0.66 | 0.75 |
10 | 0.56 | 0.88 |
11 | 0.69 | 0.87 |
12 | 0.76 | 0.87 |
Items | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | |
1 | 1 | |||||||||||
2 | 0.40 ** | 1 | ||||||||||
3 | 0.54 ** | 0.45 | 1 | |||||||||
4 | 0.56 ** | 0.32 | 0.41 | 1 | ||||||||
5 | 0.39 ** | 0.42 | 0.40 | 0.56 | 1 | |||||||
6 | 0.42 ** | 0.40 | 0.43 | 0.64 | 0.55 | 1 | ||||||
7 | 0.38 ** | 0.31 | 0.34 | 0.51 | 0.50 | 0.38 | 1 | |||||
8 | 0.24 ** | 0.28 | 0.20 | 0.18 | 0.39 | 0.26 | 0.43 | 1 | ||||
9 | 0.37 ** | 0.22 | 0.34 | 0.42 | 0.37 | 0.39 | 0.32 | 0.32 | 1 | |||
10 | 0.16 * | 0.16 | 0.29 | 0.26 | 0.32 | 0.28 | 0.41 | 0.50 | 0.43 | 1 | ||
11 | 0.30 ** | 0.23 | 0.38 | 0.43 | 0.40 | 0.43 | 0.30 | 0.34 | 0.69 | 0.57 | 1 | |
12 | 0.46 ** | 0.27 | 0.43 | 0.51 | 0.49 | 0.50 | 0.42 | 0.31 | 0.60 | 0.49 | 0.65 | 1 |
Item | Kappa |
---|---|
1 | 0.87 |
2 | 0.81 |
3 | 0.76 |
4 | 0.88 |
5 | 0.86 |
6 | 0.80 |
7 | 0.95 |
8 | 1.0 |
9 | 1.0 |
10 | 0.92 |
11 | 0.81 |
12 | 0.84 |
Item | Kappa | Agreement Percentage (%) |
---|---|---|
1 | 0.66 | 82 |
2 | 0.50 | 79 |
3 | 0.66 | 84 |
4 | 0.83 | 91 |
5 | 0.86 | 90 |
6 | 0.70 | 96 |
7 | 0.94 | 95 |
8 | 0.81 | 94 |
9 | 0.46 | 89 |
10 | 0.90 | 90 |
11 | 0.50 | 89 |
12 | 0.80 | 95 |
Cut-Off Scores | Sensitivity | Specificity |
---|---|---|
2 | 98 | 50 |
3 | 96 | 64 |
4 | 95 | 68 |
5 | 84 | 80 |
6 | 71 | 87 |
7 | 66 | 91 |
8 | 63 | 93 |
9 | 58 | 95 |
10 | 50 | 96 |
11 | 40 | 98 |
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Londe, A.C.; de Amorim, J.C.; Julio, P.R.; Wulffraat, N.M.; Marini, R.; Appenzeller, S. Cross-Cultural Adaptation and Validation of the Methotrexate Intolerance Severity Score Questionnaire in Portuguese (Brazil) for Children and Adolescents with Juvenile Idiopathic Arthritis. J. Clin. Med. 2023, 12, 1116. https://doi.org/10.3390/jcm12031116
Londe AC, de Amorim JC, Julio PR, Wulffraat NM, Marini R, Appenzeller S. Cross-Cultural Adaptation and Validation of the Methotrexate Intolerance Severity Score Questionnaire in Portuguese (Brazil) for Children and Adolescents with Juvenile Idiopathic Arthritis. Journal of Clinical Medicine. 2023; 12(3):1116. https://doi.org/10.3390/jcm12031116
Chicago/Turabian StyleLonde, Ana Carolina, Jaqueline Cristina de Amorim, Paulo Rogério Julio, Nico M. Wulffraat, Roberto Marini, and Simone Appenzeller. 2023. "Cross-Cultural Adaptation and Validation of the Methotrexate Intolerance Severity Score Questionnaire in Portuguese (Brazil) for Children and Adolescents with Juvenile Idiopathic Arthritis" Journal of Clinical Medicine 12, no. 3: 1116. https://doi.org/10.3390/jcm12031116
APA StyleLonde, A. C., de Amorim, J. C., Julio, P. R., Wulffraat, N. M., Marini, R., & Appenzeller, S. (2023). Cross-Cultural Adaptation and Validation of the Methotrexate Intolerance Severity Score Questionnaire in Portuguese (Brazil) for Children and Adolescents with Juvenile Idiopathic Arthritis. Journal of Clinical Medicine, 12(3), 1116. https://doi.org/10.3390/jcm12031116