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Article

Hematological Composite Scores in Patients with Inflammatory Bowel Disease

by
Marta Carrillo-Palau
1,
Belén Vera-Santana
1,
Andrea Morant-Domínguez
1,
Alejandro Hernández-Camba
2,
Laura Ramos
1,
Inmaculada Alonso-Abreu
1,
Noemi Hernández Álvarez-Buylla
1,
Laura Arranz
2,
Milagros Vela
2,
Manuel Hernández-Guerra
1,
Cristina Gómez-Moreno
3,
Miguel Á. González-Gay
4,5,* and
Iván Ferraz-Amaro
6,7,*
1
Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, Spain
2
Division of Gastroenterology, Hospital Universitario de Nuestra Señora de la Candelaria, 38010 Tenerife, Spain
3
Fundación Jiménez Díaz School of Nursing of Madrid, Autonomous University of Madrid, 28040 Madrid, Spain
4
Division of Rheumatology, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, 28040 Madrid, Spain
5
Department of Medicine, University of Cantabria, 39005 Santander, Spain
6
Division of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, Spain
7
Department of Internal Medicine, Universidad de La Laguna (ULL), 38200 Tenerife, Spain
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(23), 7248; https://doi.org/10.3390/jcm12237248
Submission received: 29 October 2023 / Revised: 19 November 2023 / Accepted: 21 November 2023 / Published: 23 November 2023
(This article belongs to the Special Issue Inflammatory Bowel Disease: From Diagnosis to Treatment)
Versions Notes

Abstract

The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and the systemic immune-inflammatory index (SIRI, neutrophils × monocytes/lymphocytes) have been identified as potential inflammatory biomarkers. In this work we aimed to analyze whether the hematological composite scores differ between inflammatory bowel disease (IBD) patients and healthy controls, and if they are related to disease activity. A total of 197 IBD patients—130 Crohn’s (CD) disease and 67 ulcerative colitis (UC)—and 208 age- and sex-matched healthy controls were enrolled. C-reactive protein and fecal calprotectin were assessed. Multivariable linear regression analysis was executed. After adjustment, NLR and PLR, but not SIRI and MLR, were significantly higher in IBD patients compared to controls. C-reactive protein and SIRI and NLR were correlated in IBD patients. However, fecal calprotectin was not related to any of these blood scores. Furthermore, disease activity parameters were not associated with any of the blood composite scores in both CD and UC patients. In conclusion, NLR and PLR, but not SIRI and MLR, are independently higher in IBD patients compared to controls. However, the four hematological scores are not related to disease activity in either CD or UC patients. Based on these results, blood-based inflammatory scores may not serve as subrogated biomarkers of disease activity in IBD.
Keywords: inflammatory bowel disease; systemic immune-inflammatory index; hematological inflammatory scores inflammatory bowel disease; systemic immune-inflammatory index; hematological inflammatory scores

Share and Cite

MDPI and ACS Style

Carrillo-Palau, M.; Vera-Santana, B.; Morant-Domínguez, A.; Hernández-Camba, A.; Ramos, L.; Alonso-Abreu, I.; Hernández Álvarez-Buylla, N.; Arranz, L.; Vela, M.; Hernández-Guerra, M.; et al. Hematological Composite Scores in Patients with Inflammatory Bowel Disease. J. Clin. Med. 2023, 12, 7248. https://doi.org/10.3390/jcm12237248

AMA Style

Carrillo-Palau M, Vera-Santana B, Morant-Domínguez A, Hernández-Camba A, Ramos L, Alonso-Abreu I, Hernández Álvarez-Buylla N, Arranz L, Vela M, Hernández-Guerra M, et al. Hematological Composite Scores in Patients with Inflammatory Bowel Disease. Journal of Clinical Medicine. 2023; 12(23):7248. https://doi.org/10.3390/jcm12237248

Chicago/Turabian Style

Carrillo-Palau, Marta, Belén Vera-Santana, Andrea Morant-Domínguez, Alejandro Hernández-Camba, Laura Ramos, Inmaculada Alonso-Abreu, Noemi Hernández Álvarez-Buylla, Laura Arranz, Milagros Vela, Manuel Hernández-Guerra, and et al. 2023. "Hematological Composite Scores in Patients with Inflammatory Bowel Disease" Journal of Clinical Medicine 12, no. 23: 7248. https://doi.org/10.3390/jcm12237248

APA Style

Carrillo-Palau, M., Vera-Santana, B., Morant-Domínguez, A., Hernández-Camba, A., Ramos, L., Alonso-Abreu, I., Hernández Álvarez-Buylla, N., Arranz, L., Vela, M., Hernández-Guerra, M., Gómez-Moreno, C., González-Gay, M. Á., & Ferraz-Amaro, I. (2023). Hematological Composite Scores in Patients with Inflammatory Bowel Disease. Journal of Clinical Medicine, 12(23), 7248. https://doi.org/10.3390/jcm12237248

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