Under the Hood: Understanding the Features of Mucin in Pseudomyxoma Peritonei
Abstract
:1. Introduction
- Low-grade mucinous carcinoma peritonei: characterized by low-grade cytology, few mitoses, and scant mucinous tumor epithelium (<20% of tumor volume).
- High-grade mucinous carcinoma peritonei is characterized by the presence of at least one of the following features: high-grade cytology, infiltration of adjacent tissues, invasion of vascular lymphatic vessels or surrounding nerves, cribriform growth, or extensive mucinous tumor epithelium (>20% of tumor volume).
- High-grade mucinous carcinoma peritonei with signet ring cells: characterized by the presence of neoplastic signet ring cells (signet ring cells ≥ 10%).
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Age | Sex | Primary Tumor | Perforated | PMP Classification | Preoperative Chemotherapy | Cytoreduction Score | Current Status | Overall Survival (Months) |
---|---|---|---|---|---|---|---|---|
59 | ♂ | LAMN | Yes | Metachronous LMCP (LMCP-1) | No | CC0 | AWR | 84 |
44 | ♀ | LAMN | Yes | Synchronous AM (AM-1) | No | CC0 | AWR | 79 |
45 | ♂ | LAMN | Yes | Metachronous AM (AM-2) | No | CC0 | AWR | 75 |
75 | ♀ | LAMN | Yes | Metachronous AM (AM-3) | No | CC0 | AWR | 72 |
73 | ♀ | MCA | No | Metachronous LMCP (LMCP-2) | No | CC0 | AWR | 54 |
80 | ♀ | LAMN | No | Synchronous LMCP (LMCP-3) | No | CC1 | DWR | 17 |
Patients | Samples | Mucin-1 (µg/µL) | Mucin-2 (µg/µL) | Mucin-5AC (µg/µL) |
---|---|---|---|---|
LMCP-1 | Cellular mucin | 46 | 82 | 40 |
LMCP-2 | Cellular mucin | 33 | 77 | 31 |
LMCP-3 | Cellular mucin | 35 | 70 | 42 |
AM-1 | Acellular mucin | 44 | 68 | 40 |
AM-2 | Acellular mucin | 44 | 68 | 40 |
AM-3 | Acellular mucin | 43 | 75 | 40 |
SAMPLES | MUC-2 | MUC-5AC | MUC-5B | MUC-1 | MUC-6 | MUC-4 | |
---|---|---|---|---|---|---|---|
O’Connell (2002) [7] | Appendix, ovarian, and peritoneal tissues (25) | ✓ | ✓ | ||||
Mohamed (2004) [8] | Peritoneal tissue (11) | ✓ | ✓ | ||||
Nonaka (2006) [9] | Peritoneal tissue (42) | ✓ | ✓ | ||||
Mall (2007) [10] | Mucin (cellular) | ✓ | ✓ | ✓ | ✓ | ||
Ferreira (2008) [11] | Ovarian tissue (28) | ✓ | ✓ | ||||
Baratti (2009) [12] | Peritoneal tissue (85) | ✓ | ✓ | ||||
Guo (2011) [13] | Appendix, ovarian, and peritoneal tissues (35) | ✓ | |||||
Chang (2012) [14] | Appendix tissue (22) | ✓ | ✓ | ||||
Pillai (2017) [5] | Mucin (16) | ✓ | ✓ | ✓ |
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Villarejo-Campos, P.; García-Arranz, M.; Qian, S.; Jiménez de los Galanes, S.; Domínguez-Prieto, V.; Vélez-Pinto, J.F.; Guijo Castellano, I.; Jiménez-Fuertes, M.; Guadalajara, H.; García-Olmo, D. Under the Hood: Understanding the Features of Mucin in Pseudomyxoma Peritonei. J. Clin. Med. 2023, 12, 4007. https://doi.org/10.3390/jcm12124007
Villarejo-Campos P, García-Arranz M, Qian S, Jiménez de los Galanes S, Domínguez-Prieto V, Vélez-Pinto JF, Guijo Castellano I, Jiménez-Fuertes M, Guadalajara H, García-Olmo D. Under the Hood: Understanding the Features of Mucin in Pseudomyxoma Peritonei. Journal of Clinical Medicine. 2023; 12(12):4007. https://doi.org/10.3390/jcm12124007
Chicago/Turabian StyleVillarejo-Campos, Pedro, Mariano García-Arranz, Siyuan Qian, Santos Jiménez de los Galanes, Víctor Domínguez-Prieto, Juan Felipe Vélez-Pinto, Ismael Guijo Castellano, Montiel Jiménez-Fuertes, Héctor Guadalajara, and Damián García-Olmo. 2023. "Under the Hood: Understanding the Features of Mucin in Pseudomyxoma Peritonei" Journal of Clinical Medicine 12, no. 12: 4007. https://doi.org/10.3390/jcm12124007