Next Article in Journal
Establishing an Expert Consensus on Key Indicators of the Quality of Life among Breast Cancer Survivors: A Modified Delphi Study
Next Article in Special Issue
Impact of Deprivation on Obesity in Children with PWS
Previous Article in Journal
Association between Androgen Deprivation Therapy and the Risk of Inflammatory Rheumatic Diseases in Men with Prostate Cancer: Nationwide Cohort Study in Lithuania
Previous Article in Special Issue
Sleep Disorders in Adults with Prader–Willi Syndrome: Review of the Literature and Clinical Recommendations Based on the Experience of the French Reference Centre
 
 
Article

Thrombosis Risk History and D-dimer Levels in Asymptomatic Individuals with Prader–Willi Syndrome

1
Foundation for Prader–Willi Research, Walnut, CA 91789, USA
2
Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL 32611, USA
3
Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
4
JLM Clin Dev Consulting, LLC, San Diego, CA 92120, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Assumpta Caixàs and Claudia Giavoli
J. Clin. Med. 2022, 11(7), 2040; https://doi.org/10.3390/jcm11072040
Received: 2 March 2022 / Revised: 29 March 2022 / Accepted: 1 April 2022 / Published: 5 April 2022
(This article belongs to the Collection Endocrinology and Metabolic Diseases: Prader-Willi Syndrome)
Individuals with Prader–Willi syndrome (PWS) may be at higher risk of developing blood clots as compared to the typical population, but this risk is poorly understood. It is also unclear if laboratory testing of D-dimer concentration might be useful to screen for thrombosis in PWS. Here, we surveyed the thrombosis history of 883 individuals with PWS and evaluated the D-dimer concentration in a subset of 214 asymptomatic individuals, ages 5–55. A history of at least one blood clot was reported by 3.6% of respondents. Thrombosis increased with age, but no significant difference was found on the basis of sex or family history. Genetic subtype was a significant factor when considering only those with a known subtype, and individuals with a history of edema had significantly more blood clots. In the D-dimer sub-study, ≈15% of participants had high D-dimer concentrations, and 3.7% had D-dimer values more than twice the normal upper limit. One participant with a high D-dimer result was found to have a blood clot. No significant differences in D-dimer results were found on the basis of age, sex, genetic subtype, family history of blood clots, edema history, or BMI. The D-dimer test does not appear to be a sensitive and specific screening tool for blood clots in asymptomatic individuals with PWS. View Full-Text
Keywords: Prader–Willi syndrome; thrombosis; D-dimer; blood clot Prader–Willi syndrome; thrombosis; D-dimer; blood clot
Show Figures

Figure 1

MDPI and ACS Style

Matesevac, L.; Miller, J.L.; McCandless, S.E.; Malloy, J.L.; Bohonowych, J.E.; Vrana-Diaz, C.; Strong, T.V. Thrombosis Risk History and D-dimer Levels in Asymptomatic Individuals with Prader–Willi Syndrome. J. Clin. Med. 2022, 11, 2040. https://doi.org/10.3390/jcm11072040

AMA Style

Matesevac L, Miller JL, McCandless SE, Malloy JL, Bohonowych JE, Vrana-Diaz C, Strong TV. Thrombosis Risk History and D-dimer Levels in Asymptomatic Individuals with Prader–Willi Syndrome. Journal of Clinical Medicine. 2022; 11(7):2040. https://doi.org/10.3390/jcm11072040

Chicago/Turabian Style

Matesevac, Lisa, Jennifer L. Miller, Shawn E. McCandless, Jaret L. Malloy, Jessica E. Bohonowych, Caroline Vrana-Diaz, and Theresa V. Strong. 2022. "Thrombosis Risk History and D-dimer Levels in Asymptomatic Individuals with Prader–Willi Syndrome" Journal of Clinical Medicine 11, no. 7: 2040. https://doi.org/10.3390/jcm11072040

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop